Transcript Gastric_Carcinoma_Praecancer-S Petrov - 10-12

PRECANCEROUS GASTRIC LESIONS
- our Bulgarian experience
10 – 12 – 2010
SOFIA
Stefan P. Petrov, MD; PhD
St. Ann Hospital, Sofia
The Morphology Point of the
History of the Problem 3 points:
1. Displasia
2. Intestinal Metaplasia
3. Bacteriology – Helicobacter pylori
1.DISPLASIA - 1
1.DISPLASIA - 2
2. INTESTINAL METAPLASIA - 1
2. INTESTINAL METAPLASIA - 2
2. INTESTINAL METAPLASIA - 3
2. INTESTINAL METAPLASIA - 4
2. INTESTINAL METAPLASIA - 5
2. INTESTINAL METAPLASIA - 6
3. THE NEW ERA – BACTERIOLOGY – HELICOBACTER PYLORI
3. THE NEW ERA – BACTERIOLOGY – HELICOBACTER PYLORI
UNIDENTIFIED CURVED BACILLI ON GASTRIC EPITHELIUM IN ACTIVE CHRONIC
GASTRITIS
UNIDENTIFIED CURVED BACILLI IN THE STOMACH OF PATIENTS WITH GASTRITIS
AND PEPTIC ULCERATION
BJ Marshall & JR Warren, Dept of Gastroenterology and Pathology,
Royal Perth Hospital, Perth, Western Australia
The Lancet, june 4, 1983
3. THE NEW ERA – BACTERIOLOGY – HELICOBACTER PYLORI
3. THE NEW ERA – BACTERIOLOGY – HELICOBACTER PYLORI
3. THE NEW ERA – BACTERIOLOGY – HELICOBACTER PYLORI
5. THE NEW ERA – OUR CONTRIBUTION – HELICOBACTER PYLORI - 1
Polychromatic Methods 1 – R. Genta (1994)
X 400
X 64
5. THE NEW ERA – OUR CONTRIBUTION – HELICOBACTER PYLORI - 2
Polychromatic Methods 2 – C. Doglioni (1997)
simultaneously identification of the H.P. & Helicobacter Heilmanii
X 1000
5. THE NEW ERA – OUR CONTRIBUTION – HELICOBACTER PYLORI - 3
Polychromatic Methods 3 – Hala El-Zimaity (1998)
simultaneously identification of the H.P. & Intestinal Metaplasia
X 400
X 128
X 1000
5. THE NEW ERA – OUR CONTRIBUTION – HELICOBACTER PYLORI - 4
Impregnation Methods 1 – AgNOR и H.P. – impregnation
( W.Howell & D. Black /1980/– modification by D. Plotton /1984/)
simultaneously identification of the H.P. & Proliferative Activity
X 400
X 400
X 400
5. THE NEW ERA – OUR CONTRIBUTION – TREPONEMA PALLIDA - 1
Impregnation Methods 2 – the golden standard – Whartin - Starry (1984)
Siphylitic gastropathia – 29 year man
X 128
X 400
5. THE NEW ERA – OUR CONTRIBUTION – HELICOBACTER PYLORI - 1
Combined Methods 1 – Granofurine – Evans-Blue – Jodasept
simultaneously identification of the H.P. & fluorescence (an attempt)
5. THE NEW ERA – OUR CONTRIBUTION – HELICOBACTER PYLORI - 1
PATENTED № 202 /
30.07.1998 г. INRA
Advantages of application of a
yellow filter and simple halfGram staining for detection of
Helicobacter pylori, Modern
Pathology, 8; 3, 1995, 339 –
340 pp.
5. THE NEW ERA – OUR CONTRIBUTION – HELICOBACTER PYLORI - 2
5. THE NEW ERA – OUR CONTRIBUTION – HELICOBACTER PYLORI - 2
i.e. long form
of H.P.
The First Bulgarian SEM of Helicobacter pylori – 1993 - 1
5. THE NEW ERA – OUR CONTRIBUTION – HELICOBACTER PYLORI - 3
2 long form
of H.P.
The First Bulgarian SEM of Helicobacter pylori – 1993 - 2
5. THE NEW ERA – OUR CONTRIBUTION – HELICOBACTER PYLORI - 4
“battle field”
in the ulcer
border
The First Bulgarian SEM of Helicobacter pylori – 1993 - 3
5. THE NEW ERA – OUR CONTRIBUTION – HELICOBACTER PYLORI - 5
i.e. “cigar
shaped” form
Of H.P.
The First Bulgarian SEM of Helicobacter pylori – 1993 - 4
6. THE NEW ERA – OUR RESULTS – HELICOBACTER PYLORI - 1
GASTRITES & HELICOBACTER PYLORI - 1
6. THE NEW ERA –
OUR RESULTS –
HELICOBACTER PYLORI - 2
GASTRITES
&
HELICOBACTER
PYLORI - 2
6. THE NEW ERA – OUR RESULTS – HELICOBACTER PYLORI - 3
ALL GASTRIC MALIGNANT TUMORS & HELICOBACTER PYLORI - 1
Fig 3. Helicobacter Heilmanii (4) – 0.496 % from all biopsies
and 0.98 from Helicobacter ( + ) –
association between both in 25%
6. THE NEW ERA – OUR RESULTS – HELICOBACTER PYLORI - 4
HELICOBACTER PYLORI in GASTRIC CARCINOMAS
(according to Pekka Lauren) - 2
7. THE NEW ERA – BULGARIAN PATHOLOGY ASSOCIATION
(since 2009)