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ColoPulse tablets in inflammatory bowel disease
Maurer, Jacoba
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2017
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Maurer, M. (2017). ColoPulse tablets in inflammatory bowel disease: Formulation, potential application and
evaluation [Groningen]: Rijksuniversiteit Groningen
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Download date: 24-04-2017
ColoPulse tablets in
inflammatory bowel disease
Formulation, potential application and evaluation
Jacoba Maria Maurer
Publication of this thesis was financially supported by the University of Groningen,
and Stichting ter bevordering van Onderzoek in de Ziekenhuisfarmacie te Groningen
Cover design: Jardine Media
Layout: Albertjan Tollenaar
Printed by Ridderprint BV, The Netherlands
ISBN
978-94-6299-525-3
© Marina Maurer, 2017
Copyright of the published articles is with the corresponding journal or otherwise
with the author. No part of this publication may be reproduced, stored in a retrieval
system, or transmitted, in any form or by any means, without the prior permission in
writing from the author or the copyright-owning journal.
ColoPulse tablets in
inflammatory bowel disease
Formulation, potential application and evaluation
Proefschrift
ter verkrijging van de graad van doctor aan de
Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken
en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op
vrijdag 31 maart 2017 om 16.15 uur
door
Jacoba Maria Maurer
geboren op 18 januari 1979
te Kampen
Promotores
Prof.dr. J.G.W. Kosterink
Prof.dr. H.W. Frijlink
Prof.dr. G. Dijkstra
Copromotor
Dr. H.J. Woerdenbag
Beoordelingscommissie
Prof.dr. J.H. Beijnen
Prof.dr. H. Vroomans
Prof.dr. R.K.Weersma
Contents
Chapter 1
General introduction
Chapter 2
Influence of critical process parameters on the release
characteristics of ColoPulse tablets: a quality by design
approach
13
Development and potential application of an oral
ColoPulse infliximab tablet with colon specific release:
a feasibility study
35
Population pharmacokinetics of infliximab in patients
with inflammatory bowel disease: potential implications
for dosing in clincial practice
65
A non-invasive, low-cost study design to determine
the release profile of colon drug delivery systems:
a feasibility study
87
Chapter 3
Chapter 4
Chapter 5
Chapter 6
Chapter 7
Chapter 8
1
Gastrointestinal pH and transit time profiling in
healthy volunteers using the IntelliCap system
confirms ileo-colonic release of ColoPulse tablets
105
ColoPulse tablets perform comparably in healthy
volunteers and crohn’s patients and show no influence
of food and time of food intake on bioavailability
127
General discussion and future perspectives
151
Summary
161
Samenvatting
169
Dankwoord
177
About the author
181