Transcript Quantitative CT myocardial perfusion Pelgrim, Gert

Quantitative CT myocardial perfusion
Pelgrim, Gert
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2017
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Pelgrim, G. (2017). Quantitative CT myocardial perfusion: Development of a new imaging biomarker
[Groningen]: Rijksuniversiteit Groningen
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Download date: 24-04-2017
Quantitative CT myocardial perfusion
Development of a new imaging biomarker
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Gert Jan Pelgrim
Quantitative CT myocardial perfusion: development of a new imaging biomarker
PhD thesis University of Groningen, with a summary in Dutch
ISBN: 978-90-367-9525-8 (printed version)
ISBN: 978-90-367-9524-1 (electronic version)
Copyright © Gert Jan Pelgrim
No part of this thesis may be reproduced, stored, or transmitted in any form or
by any means, without permission from the author.
Cover design and layout: Gert Jan Pelgrim
Cover image courtesy: U. Joseph Schoepf
Printed by: Ipskamp Printing, Enschede
The publication of this thesis was financially supported by:
University of Groningen, Center for Medical Imaging - North East
Netherlands, Bracco Imaging Europe BV
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Quantitative CT myocardial perfusion
Development of a new imaging biomarker
Proefschrift
Ter verkrijging van de graad van doctor aan de
Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken
en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op
maandag 27 februari 2017 om 16.15 uur
door
Gert Jan Pelgrim
geboren op 4 februari 1987
te Coevorden
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Promotores
Prof. dr. M. Oudkerk
Prof. dr. R. Vliegenthart
Beoordelingscommissie
Prof. dr. J.E. Wildberger
Prof. dr. F.W. Prinzen
Prof. dr. P. van der Harst
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Table of contents
I
Introduction
1
1
General Introduction and Outline of the Thesis
3
2 The dream of a one-stop-shop: Meta-analysis on myocardial
perfusion CT
13
II Dynamic CT perfusion measurements
39
3 Development of an ex vivo, beating heart model for CT myocardial
perfusion
41
4 Validation of myocardial perfusion quantification by dynamic CT in
an ex vivo porcine heart model
57
5 Analysis of myocardial perfusion parameters in an ex vivo porcine
heart model using third generation dual-source CT
77
6 The influence of temporal sampling rate on myocardial blood flow
measurements in third generation dual-source CT: an ex vivo porcine
heart study
93
7 Quantitative myocardial perfusion with dynamic contrastenhanced imaging in MRI and CT theoretical models and current
implementation
115
III Static CT perfusion experiments141
8
Dual-Energy of the Heart
143
9 Accuracy of iodine quantification using dual energy CT in latest
generation dual source and dual layer CT
167
10 Optimal Timing of Image Acquisition for Arterial First Pass CT
Myocardial Perfusion Imaging
183
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IV English and Dutch summary and implications197
11
English summary
199
12
Nederlandse Samenvatting
211
V
Appendices223
13
Dankwoord
225
14
List of publications
231
15
Curriculum Vitae
237
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I
Introduction
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