Transcript Title and contents - Rijksuniversiteit Groningen

Quantitative STIR MRI
as prognostic imaging biomarker for
nerve regeneration
Viddeleer, A.R.
Quantitative STIR MRI as prognostic imaging biomarker for nerve
regeneration
PhD Thesis University of Groningen, with summary in Dutch
ISBN 978-90-804995-0-8
c 2016 A.R. Viddeleer
All rights reserved. No part of this publication may be reproduced, reported
or transmitted in any form or by any means without prior written permission
from the author.
Cover & Layout: A.R. Viddeleer
Printing: Ipskamp Printing
The publication of this thesis was financially supported by the Center for
Medical Imaging (CMI-NEN) and Bracco.
Quantitative STIR MRI
as prognostic imaging biomarker for
nerve regeneration
Proefschrift
Ter verkrijging van de graad van doctor aan de
Rijksuniversiteit Groningen
op gezag van de
Rector Magnificus, prof. dr. E. Sterken
en volgens het besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op
maandag 14 november 2016 om 16.15 uur
door
Alain Robert Viddeleer
geboren 11 januari 1970
te Voorburg
Promotor
Prof. dr. M. Oudkerk
Copromotor
Dr. P.E. Sijens
Beoordelingscommissie
Prof. dr. P.P. De Deijn
Prof. dr. R.J.M. Groen
Prof. dr. T. Leiner
Paranimfen
drs. W.Y. Deurholt
drs. M.J. Santing
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Contents
Cover
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Title page
Contents
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List of abbreviations
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General Introduction
1.1 Clinical Background
1.2 Aim of this thesis . .
1.3 Outline of the thesis .
1.4 References . . . . . .
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Long-term reproducibility of phantom signal intensities
2.1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . .
2.2 Materials and methods . . . . . . . . . . . . . . . . . . .
2.2.1 Study design . . . . . . . . . . . . . . . . . . . .
2.2.2 Acquisition technique . . . . . . . . . . . . . . .
2.2.3 Intensity nonuniformity correction . . . . . . . .
2.2.4 Reproducibility . . . . . . . . . . . . . . . . . . .
2.2.5 Statistical analysis . . . . . . . . . . . . . . . . .
2.3 Results . . . . . . . . . . . . . . . . . . . . . . . . . . . .
2.3.1 Local image intensity nonuniformity correction
2.3.2 Reproducibility . . . . . . . . . . . . . . . . . . .
2.4 Discussion . . . . . . . . . . . . . . . . . . . . . . . . . .
2.5 Conclusions . . . . . . . . . . . . . . . . . . . . . . . . .
2.6 References . . . . . . . . . . . . . . . . . . . . . . . . . .
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MR intensity measurements of nondenervated muscle
3.1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
3.2 Materials and methods . . . . . . . . . . . . . . . . . . . . . . .
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Sequential Muscle MRI Correlated to Functional Outcome
4.1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . .
4.2 Materials and methods . . . . . . . . . . . . . . . . . . .
4.2.1 Patients . . . . . . . . . . . . . . . . . . . . . . .
4.2.2 Acquisition technique . . . . . . . . . . . . . . .
4.2.3 Post-processing . . . . . . . . . . . . . . . . . . .
4.2.4 Signal intensity measurements . . . . . . . . . .
4.2.5 Functional outcome . . . . . . . . . . . . . . . .
4.2.6 Statistical analysis . . . . . . . . . . . . . . . . .
4.3 Results . . . . . . . . . . . . . . . . . . . . . . . . . . . .
4.4 Discussion . . . . . . . . . . . . . . . . . . . . . . . . . .
4.5 References . . . . . . . . . . . . . . . . . . . . . . . . . .
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Quantitative Muscle STIR for Monitoring Nerve Regeneration
5.1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . .
5.2 Materials and methods . . . . . . . . . . . . . . . . . . . . . .
5.2.1 Study Design . . . . . . . . . . . . . . . . . . . . . . .
5.2.2 Acquisition technique . . . . . . . . . . . . . . . . . .
5.2.3 Post-processing . . . . . . . . . . . . . . . . . . . . . .
5.2.4 Signal intensity measurements . . . . . . . . . . . . .
5.2.5 Hand function tests . . . . . . . . . . . . . . . . . . . .
5.2.6 Statistical analysis . . . . . . . . . . . . . . . . . . . .
5.3 Results . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
5.4 Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
5.5 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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General discussion
6.1 General discussion . . . . . . . . . . . . . . . . . . . . . . . . .
6.2 Future perspectives . . . . . . . . . . . . . . . . . . . . . . . . .
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3.3
3.4
3.5
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3.2.1 Study design . . . . . . . . . .
3.2.2 Acquisition technique . . . . .
3.2.3 Post-processing . . . . . . . . .
3.2.4 Signal intensity measurements
3.2.5 Statistical analysis . . . . . . .
Results . . . . . . . . . . . . . . . . . .
Discussion . . . . . . . . . . . . . . . .
Conclusions . . . . . . . . . . . . . . .
References . . . . . . . . . . . . . . . .
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Summary
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Samenvatting
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Dankwoord
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10 Curriculum Vitae
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11 List of Publications
11.1 Peer Reviewed Journals . . . . . . . . . . . . . . . . . . . . . .
11.2 Books . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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List of Abbreviations
ANOVA
CI
DICOM
EMG
FOV
MRC
MRI
RF
ROI
SD
SE
SIR
SNR
STIR
TE
TI
TR
TSE
ANalysis Of VAriance
Confidence Interval
Digital Imaging and COmmunications in Medicine
ElectroMyoGraphy
Field Of View
Medical Research Council
Magnetic Resonance Imaging
Radio Frequency
Region Of Interest
Standard Deviation
Standard Error
Signal Intensity Ratio
Signal to Noise Ratio
Short Tau Inversion Recovery
Echo Time
Inversion Time
Repetition Time
Turbo Spin Echo
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