Transcript Section 5: Pathogenic Microbiology

Pathogenic Microbiology
Bacterial Laboratory Acquired
Infections
76% of exposures occurred in clinical labs;
6% in vaccine manufacturing facilities; 8%
in research labs.
 Exposure modes: 60% inhalation, other
exposure modes included ingestion
(intentional, poor technique such as mouth
pipetting, smoking and eating in the lab)
and secondary transmission.
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Viral Laboratory Acquired
Infections
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>70% associated with research labs; 32% of all
viral LAIs associated with animals
18% of total were Hantavirus; of these, 8% were
working with known infectious material or rodents
- others thought they were working with
uninfected rodents
16% were in clinical labs; rest were in production
or field work
Major exposure modes: inhalation, percutaneous
(especially from animals)
Rickettsial Laboratory Acquired
Infections
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All rickettsial LAIs were associated with research
laboratories
95% of overt infections were by Coxiella burnetii;
remainder were Murine typhus
All Q fever cases by inhalation; all infected staff
worked with or were in close proximity to sheep
Remaining cases were by percutaneous,
inhalation, mucous membrane or unknown
exposure modes