Transcript 下載/瀏覽Download

1
WIDE-FIELD AND HIGH-RESOLUTION OPTICAL
IMAGING FOR EARLY DETECTION OF ORAL
NEOPLASIA
Proc. of SPIE Vol.7548
Mark C. Pierce, Richard A. Schwarz, Kelsey Rosbach, Darren Roblyer, Tim Muldoon,
Michelle D. Williams, Adel K. El-Naggar, Ann M. Gillenwater, Rebecca RichardsKortum
PPT製作率:100％
Professor: WANG,CHI-JO
Student: CHEN,CHING-YUAN
Outline
2

Introduction

Wide-field imaging

High-resolution microendoscopy

Conclusions
Introduction (1/7)
3

Oral cancer is the 11th most common cancer worldwide, with an estimated
35,000 new cases and 7,500 deaths due to the disease in the US in 2009.

Current procedures for oral cancer screening typically involve visual
inspection of the entire tissue surface at risk under white light illumination.
Introduction (2/7)
4
Introduction (3/7)
5
5-year survival rates
Introduction (4/7)
6

pre-cancerous lesions can be difficult to distinguish from many benign
conditions when viewed under these conditions.

However, visual identification of oral lesions can be challenging even for
specialized clinicians, with the task made even harder for less experienced
healthcare providers.
Introduction (5/7)
7
Introduction (6/7)
8
Introduction (7/7)
9

This paper has developed both wide-field and high-resolution optical
imaging devices for cancer detection, evaluating large scale prototypes in
US-based clinical studies.
Wide-field imaging (1/2)
10
Wide-field imaging (2/2)
11
High-resolution microendoscopy(1/2)
12
High-resolution microendoscopy(2/2)
13
Conclusions
14

We have demonstrated the ability of these systems to detect relevant
biochemical and morphological indicators of disease in oral mucosa,
namely stromal collagen auto-fluorescence, and epithelial call morphology.

Both wide-field and high-resolution systems have been assembled for
under $4000 each, and are currently under evaluation in pilot clinical
studies.
15
Thank You!