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生物技術概論(高立圖書)
第十章
10-1
Squalamine Family of Aminosterol Antibiotics from
Various Shark Species
The FASEB Journal. 2007;21:791.4
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Squalamine is a sulfated aminosterol, originally detected in Squalus
acanthias (spiny dogfish shark) due to its broad-spectrum
antimicrobial (antibiotic) activity. Large-scale natural product
extraction of spiny dogfish liver has established that squalamine can
be isolated in considerable quantities, along with smaller amounts of
structurally related aminosterols. In addition to antibiotic activity,
each aminosterol has another remarkable pharmacological property,
such as antiangiogenesis activity, appetite suppression, or inhibition
of sodium proton exchanger proteins. These water-soluble steroids
have therapeutic potential in treating various human diseases. To
investigate the biosynthesis of these compounds, a mini-scale
extraction scheme was devised first to determine their subcellular
localization. In spiny dogfish liver, both the total membrane and grey
fat fractions are very rich in these amphipathic aminosterols.
生物技術概論(高立圖書)
第十章
10-2
生物技術概論(高立圖書)
第十章
10-3
10.4.2 監測健康與人類疾病
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鱟魚(Limulus polyphemus)
鱟屬變形細胞溶胞產物
(LAL)試驗[Limulus
Amoebocyte Lysate (LAL)
test]
細菌性內毒素(endotoxins)
生物技術概論(高立圖書)
第十章
10-4