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Research Integrity Lecture Series A rude awakening and a journey to improved data storage and curation or Making Lemonade and the Search for Practical Data Solutions for Investigators Mark E Anderson, MD, PhD Disclosures Name Type of Financial Relationship Name of Company Mark Anderson, M.D., Ph.D. Grant Research Funding NIH/NHLBI Ownership Interest Allosteros Therapeutics Grant/Research NIH/NIDDK Grant/Research PCORI Jeanne Clark, M.D., M.P.H. An Overview • A Google search and a rude awakening (12/2012) • Hiding in plain sight • Early efforts to improve data storage and curation in our lab • Repeating experiments • The ORI process, sanctions (11/2014), retractions and reflection • Reaching out and learning that (almost) no one has a data solution • What is expected of you – by the NIH, by journals, by Johns Hopkins? • Using this experience as a motivation to advance data storage and curation for researchers • Various solutions, some clear limitations and next steps Public scrutiny: hiding in plain site Greuter Mol Cell 2009 Lab meeting discussions and developing a policy • Science fraud website • Brainstorming • What is the goal • What can be achieved? • Our ‘solution’ • Looking for more • A silent period and repeating experiments • ORI sanctions Dzhura Igor Dzhura, PhD Dzhura Nat Cell Biol 2000 ORI (Office of Research Integrity) Reaching out • 23 coauthors • ~75 collaborators, friends and mentors • Search committee chair • Many have had a close call and no one has a coherent plan NIH Journals University What is expected of you? http://www.hopkinsmedicine.org/som/faculty/policies/facultypolicies/responsible_conduct.html Bottom line: Johns Hopkins owns the data but you are responsible for custody Indemnification, guidance, resources…. Various solutions, some clear limitations and next steps Clinical versus non-clinical Large data sets What are primary data? What are the goals and a quest for practical solutions? Panel Discussion • SOM Data Integrity and Curation Task Force Mark E. Anderson, MD, PhD Jeanne Clark, MD Julie Gottlieb, MA Gregory Kirk, MD, MPH, PhD Mollie K. Meffert, MD, PhD Brian O’Rourke, PhD Stuart C. Ray, MD, FIDSA Randall Reed, PhD Antony Rosen, MD Gary Rosner, ScD • Goal: develop best practices and data storage solutions for investigators • Best probably does not mean perfect • Practical first steps based on the question “can you readily locate data from a certain figure in a paper you published 5-10 years ago?” Panel Discussion • • • • Mark Anderson, M.D., Ph.D. Jeanne Clark, M.D., M.P.H. Gary Rosner, SCD Stuart Ray, M.D. • Julie Gottlieb, M.A - Moderator