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Research Integrity Lecture Series
A rude awakening and a journey to improved data storage and curation
or Making Lemonade and the Search for Practical Data Solutions for Investigators
Mark E Anderson, MD, PhD
Disclosures
Name
Type of Financial
Relationship
Name of Company
Mark Anderson, M.D.,
Ph.D.
Grant Research Funding
NIH/NHLBI
Ownership Interest
Allosteros Therapeutics
Grant/Research
NIH/NIDDK
Grant/Research
PCORI
Jeanne Clark, M.D., M.P.H.
An Overview
• A Google search and a rude awakening (12/2012)
• Hiding in plain sight
• Early efforts to improve data storage and curation in our lab
• Repeating experiments
• The ORI process, sanctions (11/2014), retractions and reflection
• Reaching out and learning that (almost) no one has a data solution
• What is expected of you – by the NIH, by journals, by Johns Hopkins?
• Using this experience as a motivation to advance data storage and curation for researchers
• Various solutions, some clear limitations and next steps
Public scrutiny: hiding in plain site
Greuter Mol Cell 2009
Lab meeting discussions and developing a policy
• Science fraud website
• Brainstorming
• What is the goal
• What can be achieved?
• Our ‘solution’
• Looking for more
• A silent period and repeating experiments
• ORI sanctions Dzhura
Igor Dzhura, PhD
Dzhura Nat Cell Biol 2000
ORI (Office of Research Integrity)
Reaching out
• 23 coauthors
• ~75 collaborators, friends and mentors
• Search committee chair
• Many have had a close call and no one has a coherent plan
NIH
Journals
University
What is expected of you?
http://www.hopkinsmedicine.org/som/faculty/policies/facultypolicies/responsible_conduct.html
Bottom line: Johns Hopkins owns the data but you are responsible for custody
Indemnification, guidance, resources….
Various solutions, some clear limitations and next steps
Clinical versus non-clinical
Large data sets
What are primary data?
What are the goals and a quest for practical solutions?
Panel Discussion
• SOM Data Integrity and Curation Task Force
Mark E. Anderson, MD, PhD
Jeanne Clark, MD
Julie Gottlieb, MA
Gregory Kirk, MD, MPH, PhD
Mollie K. Meffert, MD, PhD
Brian O’Rourke, PhD
Stuart C. Ray, MD, FIDSA
Randall Reed, PhD
Antony Rosen, MD
Gary Rosner, ScD
• Goal: develop best practices and data storage solutions for investigators
• Best probably does not mean perfect
• Practical first steps based on the question “can you readily locate data from
a certain figure in a paper you published 5-10 years ago?”
Panel Discussion
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Mark Anderson, M.D., Ph.D.
Jeanne Clark, M.D., M.P.H.
Gary Rosner, SCD
Stuart Ray, M.D.
• Julie Gottlieb, M.A - Moderator