Transcript Chapter 66: Natural Products: Synthesis of Camphor from Camphene

Chapter 66
Natural Products: Synthesis of
Camphor from Camphene
Purpose
• Please look in the textbook for the reaction mechanism
• This experiment represents an example of a “total
synthesis” research project
Comments
• Follow the macroscale experimental procedure
from Chapter 66.
• Your product from each step is the starting
material for subsequent steps in the synthesis.
• Therefore, it’s critically important to be accurate,
because loss of the product from any step may
result in restarting the lab from camphene.
• Check purity of all products by using GC/MS,
NMR and IR analysis.
• Calculate yields.
Safety
• Flammable solvents are used in this
experiment; keep away from open flame.
• KOH and acetic acid is corrosive, handle with
care.
• Jones’
reagent
is
highly
corrosive,
carcinogenic and teratogenic. Never discard it
to the sink.
• Gloves and goggles are strictly required.