Transcript Discovery of sulfone non-nucleoside HIV-1 reverse

PASTEUR INSTITUTE SEMINAR SERIES
BIOLOGIA MOLECOLARE
Giovedì 29 settembre, ore 16:00
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presso l'Aula Magna - Viale Regina Elena 295
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DEGLI EUCARIOTI
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Prof. Romano Silvestri
DI INTERESSE B
Dept.
of Drug Chemistry and Technologies,
Sapienza Università
Istituto Pasteur Italia
BIOL
Discovery of sulfone non-nucleoside
HIV-1 reverse transcriptase inhibitors
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HIV-1 non-nucleoside reverse transcriptase
DEGLI EUCARIOTI inhibitors (NNRTIs) represent
one of the most significant classes of drugs for the treatment of AIDS/HIV
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infection. Over the past years several
potent sulfone-based HIV-1 NNRTIs
INTERESSE B
and related analogs have been DI
developed.
We provide an overview of the
drug design and structure–activity relationships of these sulfone-based HIV-1
NNRTIs. The structural information useful for the design and development of
new sulfur containing NNRTIs with enhanced antiretroviral activity against
HIV-1 wild type and clinically relevant drug resistant HIV-1 mutant strains is
also discussed.
per informazioni: [email protected]