Transcript Prevention of the disease Erythroblastosis4

ERYTHROBLASTOSIS FETALIS
PREVENTION OF THE DISEASE
A potentially life threatening blood disorder in a foetus
or a newborn, arising due to incompatibility with
mother’s blood.
SUPRIYA SARASWATI
INSTRUCTIONS SLIDE
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Master layout or diagram
• Make a schematic diagram of the concept
• Explain the animator about the beginning and ending of
the process.
• Draw image big enough for explaining.
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• In above image, identify and label different components
of the process/phenomenon. (These are like characters
in a film)
• Illustrate the basic flow of action by using arrows. Use
BOLD lines in the diagram, (minimum 2pts.)
• In the slide after that, provide the definitions of ALL the
labels used in the diagram
MASTER LAYOUT
Part Four: PREVENTION OF EF
Rh- mother receiving anti Rh
antibodies injection
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Definitions of the components:
1. Anti Rh antibodies: These are antibodies to the Rh factor that are
administered into the mother during anytime
there is a chance of mixing of the mother’s blood
with that of the fetal blood. This could be anytime
during pregnancy, labour or birth.
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Explain the process
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In this step, use an example to explain the concept. It
can be an analogy, a scenario, or an action which
explains this concept/process/topic
Try to use examples from day-to-day life to make it
more clear
You have to describe what steps the animator should
take to make your concept come alive as a series of
moving images.
Keep the examples simple to understand, and also to
illustrate/animate.
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Analogy / Scenario / Action
The immune system of the body is well developed to fight infections and
keep the body healthy. Any foreign substance (antigen) entering the
body makes the immune system produce molecules called antibodies
that destroy the antigen.
Blood transfusions are procedures of transferring blood or blood based
products from one circulatory system into another. For this the blood of
the donor should be compatible with that of the recipient’s blood, which
means the blood types should match. Or else any component not
matching the recipient’s blood type will lead to production of antibodies
in his body against the donor’s blood cells. These antibodies will attack
the newly received blood and kill the blood cells.
Erythroblastosis fetalis is a diseased condition arising from
incompatibility of fetal blood with that of the maternal blood. It usually
happens in Rh- women carrying Rh+ fetus. Maternal antibodies attack
the fetal blood cells and destroy them.
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Stepwise description of process
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The goal of the IDD is to provide instructions to an animator who is
not a expert.
You have to describe what steps the animator should take to make
your concept come alive as a moving visualization.
Use one slide per step. This will ensure clarity of the explanation.
Add a image of the step in the box, and the details in the table
below the box.
You can use any images for reference, but mention about it's
copyright status
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The animator will have to re-draw / re-create the drawings
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Add more slides as per the requirement of the animation
Step 23:
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Action
Show
Rhwoman
being
injected
Description of the action
•Show Rh- woman being injected
with IgG anti Rh antibodies.
•Show IgG anti Rh antibody
molecules entering her circulation.
Audio Narration
IgG anti Rh antibodies are
administered to the mother, against
the Rh antigen after any chance
event that could lead to mixing of the
fetal blood with that of mother’s.
Step 24:
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Action
Description of the action
Audio Narration
Show binding Show that the administered Antibodies administered to the mother
facilitate the clearance of fetal RBCs
of IgG anti
antibodies bind to any fetal
from mother’s circulation before
Rh
RBCs present in the mother’s memory cell production can take place
antibodies to blood.
and pose threat to the fetus.
fetal RBCs.
Step 25:
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RhoGAM
MICRhoGAM
Gamulin Rh
Bay Rho-D
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Action
Show brand
names of
IgG anti Rh
antibodies
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Description of the action
Show different vials labeled
with different names of
commercially available IgG
anti Rh antibodies, as shown
in the figure.
Audio Narration
IgG anti Rh antibodies are used for
preventive measures in cases of
erythroblastosis fetalis. These are
available commercially under
various brand names.
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Animation design
• Please see the design template provided in
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the next slide.
• This is a sample template, and you are free
3 to change as per your design
requirements.
• Try and recreate the sections/subsections
as shown in the template.
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Interactivity and Boundary limits
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In this section, you will add the ‘Interactivity’ options to the
animation.
Use the template in the next slide to give the details.
Insert the image of the step/s (explained earlier in the
Section 3) in the box, and provide the details in the table
below.
The details of Interactivity could be:
 Types: Drop down, Slider bar, Data inputs etc.
 Options: Select one, Multiple selections etc
 Boundary Limits: Values of the parameters, which won’t
show results after a particular point
 Results: Explain the effect of the interaction in this column
Add more slides if necessary
Interactivity option 1:Step No:
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Which of these should be injected into Rh- mother carrying Rh+ fetus
for prevention of erythroblastosis fetalis?
Dexamethasone
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BCG
RhoGAM
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A
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C
B
Interacativity Type
Choosing the
correct option
box
Options
The correct
answer box turns
green on clicking.
The incorrect
answer box turns
red on clicking.
Boundary/limits
Results
Box C is the
correct answer.
Boxes A and B
have incorrect
answers.
Links for further reading
Reference websites:
www.nlm.nih.gov
http://en.wikipedia.org
www.marchofdimes.com
www.mercksource.com
Books:
Textbook of Immunology, Kuby
Textbook of Medical Physiology, Guyton
Research papers: