Transcript Today: : Conclusion of Grignard. TLC MiniQuiz

Today:
•Conclusion of Grignard. TLC
•MiniQuiz
Next Tuesday, 10/14:
LabLecture :
Your Questions. Introduction to Unknowns.
In Lab:
Midterm, 2:10 – 4pm, in your lab
Midterm Exam (100 points)
Tuesday, October 14, 2008, 14:10 - 16:00 in your lab
Five problem sets.
Covers the material of labs and lab lectures during the first half of
the semester (including Grignard/TLC). The exam will address
chemical structures and reactions, procedures and reasons for
them, calculations, problem sets, spectra related to our
experiments, practice questions, lab lectures.
See sample exams for style of problems.
Rules:
Cell phones off and in your pack.
Do bring a calculator, but not a "computer". No sharing ...
Do not leave the room during the exam.
No extra note paper; use back of pages if necessary.
Please no questions during exam (unless you discover a serious
mistake). You can write: "if I understand the question this way ..."
No "late" exams... A midterm not taken earns the grade "F".
Start studying early.
Read questions carefully.
Proofread!
Grignard
Our multistep synthesis of triphenyl methanol, starting
with the synthesis of our Grignard reagent:
Grignard
Adduct
RMgX – Ether Complex
What is the purpose of adding dilute sulfuric acid to the
adduct mixture?
Why do we add ligroin to the ether before evaporating to
obtain our product?
Write the structure of the product obtained if our Grignard
reagent reacts with
a) water
b) methanol
c) benzoic acid
d) carbon dioxide
e) acetone
f) formaldehyde
What type of reactions are Grignard reactions?
• Grignard reagents are metal-organic compounds. Other
examples of metal-organic compounds? Are there any in nature?
CH
CH 2 CH 3
H3 C
CH 2 CH 3
N
N
Mg
H3 C
N
N
CH 3
H
H H
CH 3 OOC
O
O
O
Chlorophyll a
TLC
Thin Layer Chromatography is an example of
chromatography.
•Do you know other types of chromatography?
•What is common to all types of chromatography?
TLC
What is the moving phase, the stationary phase in
our TLC?
What type of information do we expect from our
TLC?
Next time (10/14):
Your questions…
Introduction to Unknowns
In Lab:
Midterm, 2:10 – 4pm