Study of HIV-2 in monkey

Pigtail macaque (

Macaca nemestrina

) Baboons (

Papio cynocephalus

)

- This species are susceptible to infection with some isolates of HIV-2.

- HIV-2 have been developed that induce AIDS-like disease and depletion of CD4+ cell.

- Similarities in disease progression and development of AIDS to human HIV infection.

Study of Simian immunodeficiency virus (SIV) in non human primate model -SIV is lentivirus and close related to HIV-1, HIV-2 -It share up to 50% similarity to HIV-1 in nucleotid level and share about 88% of amino acid homology to HIV-2