Transcript ) Case study in pharmacognosy: Capsicum (chili pepper capsaicin

Case study in pharmacognosy:
Capsicum (chili pepper)
H3CO
HO
O
N
H
capsaicin
Ancient Mesoamerican people used
chili peppers as a spice and medicinal
QuickTi me™ and a
GIF decompressor
are needed to see thi s pi ctur e.
QuickTi me™ and a
GIF decompressor
are needed to see t his pict ure.
Later pepper
rubs and plasters
become a folk
then patent
medicine
treatment for
pain.
UCSF Study Suggests Capsaicin Significantly
Reduces Debilitating Nerve Pain. Mice without
capsaicin receptor don’t experience pain from
heat (Science,2000).
capsaicin receptor
capsaicin activated channel
Sensory nerve terminal
Substance P
Ca++
neurogenic
inflammation
Time
QuickTi me™ and a
GIF decompressor
are needed to see thi s pi ctur e.
capsaicin
The next step??
H3CO
HO
O
N
H
capsaicin