Transcript Research Opportunities in the Department of Otolaryngology-Head and Neck Surgery Kibwei A.

Research Opportunities in the Department of
Otolaryngology-Head and Neck Surgery
Kibwei A. McKinney, MD
Yu-Tung Wong, MD
Scott Shadfar, MD
Outline
• Funding opportunities
• Subspecialty Areas
• Clinical/Research Faculty
– Areas of Interest
• Examples
ENT Residency Application
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Step 1 USMLE Score
Medical School GPA
Extra-curricular Activities
Research
Duration of Research
• 2 months – Projects completed during the
summer in between the 1st and 2nd yr
• 1 year – Projects completed during a year off
in between the 3rd and 4th years of medical
school
Grants/Funding Opportunities
• 2 months – Research Training in Otolaryngology
Program (8-12 weeks)
– Application online at Carolina Medical Student
Research Program website:
www.med.unc.edu/rschofc/omsr/cmsrp.htm
– Due Feb. 8th, 2010
• 1 year - https://cgibd.med.unc.edu/omsr/oppor.php
– Research Training in Otolaryngology
– Doris Duke Clinical Fellowship Program
– American Otologic Society Research Fellowship (T32)
– Howard Hughes Medical Institute Training Fellowship
– Holderness Fellowship (4 Yearly)
Otolaryngology Subspecialty Areas
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Head and Neck Surgery (Cancer Research)
Otology/Neurotology
Facial Plastic Surgery
Rhinology/Sinus Surgery
Laryngology
Anterior Skull Base Surgery
Pediatric Otolaryngology
Head and Neck Surgery
• Marion Couch, MD, Ph. D.
– Cancer Cachexia
• Neil Hayes, MD, MPH –
Molecular pathogenesis
of head and neck Cancers
• Mark Weissler, MD –
Outcomes Research in
Head and Neck Cancer
• Carol Shores, MD – EBV
related Head and Neck
Cancer in Lilongwe,
Malawi
Cancer Cachexia
• Loss of weight, muscle atrophy, catabolism
associated with end-stage cancer
• Significant cause of morbidity
Cancer Cachexia
• Historically thought to be mediated by increased
energy expenditure by rapidly proliferating cancer
cells
• Increasing body of evidence attributing cachexia
to pathophysiologic mechanisms at the cellular
level
• NF-κB – ubiquitous protein complex that controls
DNA replication
– When constitutively active, proper regulation does
not occurcellular proliferationtumor
– AlsoInflammation (possibly leading to cachexia)
Resveratrol
• Potential NF-κB Inhibitor
• Natural compound found in
red wine, red grapes
• Increased life span of
nematode and short-lived
fish
• If good enough for the
nematode, why not for us?
Putting Resveratrol to the Test
Day 0 –
Tumor
Inoculation
Days 1-17 Document
Cachexia/Treat with
Resveratrol
Sacrifice and
Harvest
Outcomes
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Tumor size
Body weight
Tissue NFκB levels
Cardiac echo readings
Otology/Neurotology
• Doug Fitzpatrick, Ph. D. – Preservation
of residual hearing in cochlear
implantation
• Paul Manis, Ph. D. – Cellular
mechanisms/neural networks of hearing
• John Grose, Ph. D. – Age-Related decline
in temporal processing
• Craig Buchman, MD – Auditory
Neuropathy, CI Outcomes
• Oliver Adunka, MD – Electroacoustic
Stimulation (EAS); Intraoperative
electrophysiology
• Joe Hall Ph. D./Emily Buss –
Psychoacoustics
• Joseph Roche, MD – SNHL and synaptic
plasticity in Te1
Vestibulocochlear system of
the Mongolian Gerbil; animal
model used in electroacoustic
studies
Facial Plastic and Reconstructive
Surgery
• William Shockley, MD
• Interests: Microtia
repair, nasal defects
and rhinoplasty,
congenital anomalies
• Clinical Outcomes
Research
Rhinology/Sinus Surgery
• Julia Kimbel, Ph. D. –
computational fluid
dynamics, particle uptake
deposition
• Brent Senior, MD – MIPS
Outcomes Research,
Sleep Research
• Charles Ebert, MD – QOL
Outcomes for sinus
surgery, Allergic Fungal
Rhinosinusitis
Allergic Fungal Rhinosinusitis
• Disease process characterized by
fungal proliferation,
inflammation and deformation of
the normal bony anatomy
• Presents unilaterally in over 40%
of patients
• Hypothesis: These patients
represent a genetic chimera with
differential expression on the
contralateral sides of the nose
• Microarray analysis will be used
to characterize these differences
Laryngology
• Robert Buckmire - Medical Robotic System for
Laser Phonomicrosurgery
– Joint venture with UNC/NC State Dept. of
Biomedical Engineering
• Image Guidance in
Laryngeal Surgery
Laryngeal Phonomicrosurgery
• Group of Complex
surgical techniques that
leverage the use of
endoscopic tools
• Surgical laser (CO2)
under the control of a
micromanipulator
• Problem: poor
ergonomics
Laryngeal Phonomicrosurgery
• Hypotheses:
– Different user interfaces
may be advantageous in
providing increased fine
motor manipulation of the
laser.
– A trained robot may make
more precise, uniform cuts
than those made by a
human
Skull Base Surgery
• Adam M. Zanation, MD
– Molecular biology of
sinonasal tumors,
radioanatomic analysis
of the pediatric skull
base, outcomes
research in endoscopic
skull base surgery
P
GP
Mu
PCF
cos
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PP
GF
MPC
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Pediatric Otolaryngology
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Amelia Drake, MD
Austin Rose, MD
Carlton Zdanski, MD, FACS
Rose Payapilli, MD
(resident) – clinical
outcomes in patients with
cochlear malformation
after CI