NIH Office of Extramural Research EB2013/FASEB – April 2013 Mapping Your Career with NIH Henry Khachaturian, Ph.D. Acting NIH Research Training Officer Office of Extramural.
Download ReportTranscript NIH Office of Extramural Research EB2013/FASEB – April 2013 Mapping Your Career with NIH Henry Khachaturian, Ph.D. Acting NIH Research Training Officer Office of Extramural.
NIH Office of Extramural Research EB2013/FASEB – April 2013 Mapping Your Career with NIH Henry Khachaturian, Ph.D. Acting NIH Research Training Officer Office of Extramural Research, NIH Email: [email protected] 1 National Institutes of Health Our mission is to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce the burdens of illness and disability. World’s largest source of funding for biomedical research Support more than 300,000 research personnel at over 3,000 universities and research institutions 27 Institutes and Centers (ICs) with specific research agendas 2 FY 2015 President’s Budget: $30,361,653 Research Mgmt & Support: All Other: 5.0% 2.0% Research Training: 2.5% Other Research: 3.5% Research Project Grants: 53.0% Career Dev. 2.1% Research Centers: 10.0% R&D Contracts: 11.0% $767,132 Training $626,778 Career $1,393,910 Intramural Research: 10.0% NIH Budget Office: http://officeofbudget.od.nih.gov/index.htm 3 3 NIH New Investigators Programs National Research Service Award (NRSA) Institutional Training Grants and Individual Fellowships Research Career Development Awards New and Early-Stage Investigators 4 Training & Career Development Support 2014 Research Awards Career Stage Pre-Bac ‘Informal’ Training and Career Development on RPGs and Supplements GRADUATE/ MEDICAL STUDENT POST DOCTORAL EARLY Research Project Grant (R01) Exploratory/Develop -ment Grant (R21) CAREER Small Grant (R03) MIDDLE ‘Formal’ Training/Career Awards Pre-Bac Institutional Training Grant (T34) Predoctoral Institutional Training Grant (T32) Predoctoral Individual NRSA (F31) Predoctoral Individual MD/PhD NRSA (F30) Postdoctoral Institutional Training (T32) Postdoctoral Individual NRSA (F32) $767M $627M NIH Pathway to Independence (PI) Award (K99/R00) Mentored Research Scientist Development Award (K01) Mentored Clinical Scientist Development Award (K08) Mentored Patient-Oriented RCDA (K23) Mentored Quantitative RCDA (K25) Independent Scientist Award (K02) Midcareer Investigator Award in Patient-Oriented Research (K24) SENIOR Senior Scientist Award (K05) 5 Advice for Mapping Your Career With NIH Review Institute/Center (IC) priorities and goals. Each IC has a research training and career development program. Learn the NIH application and review process Identify the grant programs offered by each IC Make early contact with program officers Find innovative, well-respected mentors and collaborators Study successful grant applications- talk to your mentor Propose your best and most creative ideas 6 Career Path for a Research Doctoral Degree (Ph.D. or equivalent) T32 F31 Graduate student F32 K99/ or K22 R00 T32 Ph.D. Postdoc R03 R21 R01 Faculty Position Ps K02 F33 Us R37 Independent PI Diversity Supplements T32- Institutional training grant (NRSA)-has pre-& postdoc slots F30 and F31- Individual predoc fellowship (NRSA) (some ICs only support Diversity F30/31s) F32- Individual postdoc fellowship (NRSA) F33- Sr. postdoc fellowship (NRSA) K02- Independent Scientist Award K22- Research Scholar Development Award K99/R00- Pathway to Independence Award R37- Merit award P01- Program Project Grant U01- Cooperative Agreement R03- Small Grant R21- Exploratory/Developmental Research Grant R01- Research grant 7 Career Path for a Clinical Doctoral Degree (M.D. or equivalent) T35 F30 Medical Student M.D. T32 K08 K99/ or or K22 R00 F32 K23 Clinical Training R03 R21 R01 K02 F33 K24 R37 Faculty Position Independent PI Diversity Supplements T35- Short-term Training Grant for Health Professional Students F33- Sr. Postdoctoral Fellowship (NRSA) K08- Mentored Clinical Scientist Development Award K23- Mentored Patient-Oriented Research Career Development Award K24- Mid-Career Investigator in Patient-Oriented Research K07, K12- IC specific Plus all mechanisms from Ph.D. track 8 NIH New Investigators Programs National Research Service Award (NRSA) Institutional Training Grants and Individual Fellowships Research Career Development Awards New and Early-Stage Investigators 9 Research Training Awards Authority • Established by the NRSA Act of 1974. ̶ Section 487 of PHS Act; Regulations at 42 CFR 66. • Replaced all previous NIH training authority. • Name change legislation passed August 2002. • Supported by 22 of the 24 awarding NIH Institutes and Centers (FIC and NLM have own authority). • Supported by the Agency for Health Care Research and Quality (AHRQ) and the Health Resources Services Administration (HRSA). • 2 types of awards: ̶ ̶ Institutional, e.g. T32, T34, T35, T90/R90. Individual, e.g. F30, F31, F32, F33. 10 National Research Service Award Policies Policies that apply to both Training Grants and Fellowships… Guidelines: • NIH Grants Policy Statement, Kirschstein— NRSA Section: http://grants.nih.gov/grants/policy/nihgps_2011/nihgps_ch11.htm • Program Announcements & Other Information: http://grants.nih.gov/training/nrsa.htm 11 Citizenship Requirements • Must be Citizen, non-citizen national, or lawfully admitted for permanent residence • Permanent Residents: – Fellowships: Must have been admitted as a Permanent Resident by the time of award – Training Grants: Must have been admitted as a Permanent Resident at time of appointment 12 Degree Requirements • Pre-Baccalaureate: Currently enrolled as an honors undergraduate at designated institutions (MARC and COR trainees). • Predoctoral: Must have a baccalaureate degree and be enrolled in doctoral program leading to PhD or equivalent, or dual research/clinical doctorate such as the MD/PhD. • Postdoctoral: Must have a PhD or MD or comparable doctoral degree from an accredited domestic or foreign institution. 13 NRSA Limitations Duration of Support: – Predoc: 5 years* – Postdoc: 3 Years – Aggregate limits apply: any combination from individual and/or institutional awards Exceptions: – Physicians/Clinicians (*combined-degree F30 allows 6 years) – Interruptions (break in service) – Waiver request requires IC prior approval 14 Ruth L. Kirschstein National Research Service Awards Overview: The overall goal of the NIH Ruth L. Kirschstein National Research Service Award (NRSA) program is to help ensure that a diverse pool of highly trained scientists is available in appropriate scientific disciplines to address the Nation's biomedical, behavioral, and clinical research needs. NRSA Opportunities: Institutional Training grants (Ts): Multi-slot awards that are used to support research training activities for several individuals. Individual Fellowships (Fs): Awards for graduate students working on a doctoral degree and researchers who have just earned their doctorates (postdocs). 15 NRSA Institutional Training Grants Overview: Training programs to prepare qualified individuals for careers that have a significant impact on the health-related research needs of the Nation. Awarded to domestic institutions. Trainees work in mentors’ labs. Core Review Criteria: 1. Training Program and Environment 2. Training Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) 3. Preceptors/Mentors 4. Trainees 5. Training Record Available for Predoctoral and/or Postdoctoral researchers. Additional Review Consideration: 1. Recruitment & Retention Plan to Support basic and/or clinical researchers. Enhance Diversity 2. Training in the Responsible T-Kiosk: http://grants.nih.gov/training/T_Table.htm Conduct of Research 16 NRSA Individual Fellowships Overview: Awarded to Predoctoral or Postdoctoral fellows who are working with mentors. Training can be at domestic or foreign institutions. Opportunities in basic and/or clinical research. Open to any scientific area within the NIH scientific mission. PhDs and MD/PhDs receive most of the awards. F-Kiosk: Core Review Criteria: 1. Fellowship Applicant – Academic record and training, publications, etc. 2. Sponsors, Collaborators, and Consultants 3. Research Training Plan 4. Training Potential 5. Institutional Environment & Commitment to Training Additional Review Consideration: 1. Training in the Responsible Conduct of Research http://grants.nih.gov/training/F_files_nrsa.htm 17 F30 and F31 Predoctoral Fellowships Overview: Program Features: Support Predoctoral Fellows during graduate (possibly medical) training. • Stipend: F30 (MD/PhD) may support up to 6 years of training. • Tuition/Fees: F31 is limited to 5 years total. Promising doctoral candidates who will be performing dissertation research. Some Institutes and Centers only support Diversity F31s. Fellows may not change the scope, move fellowship, or change mentor without prior NIH approval! FY 2015: $22,920 60% of requested tuition, capped at $16,000 ($21,000 for MD/PhD programs) • Institutional Allowance: $4,200 Includes health insurance • Travel Allowance: Part of IA 18 F32 Postdoctoral Fellowships Overview: Program Features: • Stipends: Support Postdoctoral research training. Promising fellows with the potential to become productive, independent investigators in scientific healthrelated research fields relevant to the missions of NIH Institutes & Centers. NRSA support for up to 3 years total. Awardees incur two years of payback. Repay the 1st year by staying in research a 2nd year Fellows may not change the scope, move fellowship, or switch mentor without prior NIH approval! FY 2015: $42,840 (Level-0) to $56,376 (Level-7) • Tuition/Fees: 60% of requested tuition, capped at $4,500 ($16,000 for those seeking another doctoral degree) • Institutional Allowance: $7,850 Includes health insurance • Travel Allowance: Up to $1,000 19 Kirschstein-NRSA training grants and fellowships Full-time training positions awarded 20 Kirschstein-NRSA predoc fellowships (F31s) Applications, awards, and success rates 21 Kirschstein-NRSA postdoc fellowships (F32s) Applications, awards, and success rates 22 NIH New Investigators Programs National Research Service Award (NRSA) Institutional Training Grants and Individual Fellowships Research Career Development Awards New and Early-Stage Investigators 23 Research Career Development Authority Authorized by Sections 301 and 405 of PHS Act. 42 U.S.C. 241 and 284; Regulations at 45 CFR 74 & 92 K-Awards provide “protected time” to engage in research and enhance research capabilities. Early, mid, & senior level awards. Majority require 75% of full time research effort. Applicants must hold a research or health professional doctoral degree. U.S. citizenship or permanent residency required. 2 types of awards: Individual, e.g. K01, K02, K08, K18, K22, K23, K24, K25, K99/R00 Institutional, e.g. K12, CTSA (KL2) 24 Career Development Award Eligibility U.S. Citizens, Non-Citizen Nationals, Permanent Residents (except K99/R00). Research doctoral degree (K01, K02), but some require clinical doctoral degree (K08, K23, K24). Must devote a minimum of 75% effort to research and career development activities. There are exceptions. Previous NIH Principal Investigators may be Ineligible. Principal Investigators on R03 or R21 are eligible to apply (except K99/R00). Principal Investigators on R01 or subproject Principal Investigators on a P01 are not eligible to apply. 25 Research Career Development Awards Overview: Institutional and Individual Awards. Opportunities for basic and clinical investigators. Mix of mentored and independent mechanisms. Some designed as awards for faculty investigators. Newer programs (K22 and K99/R00) are transition awards for MDs and PhDs. K-Kiosk: http://grants.nih.gov/training/careerdevel opmentawards.htm 26 Core Review Criteria: 1. Candidate 2. Career Development Plan/Career Goals & Objectives (or Plan to Provide Mentoring*) 3. Research Plan 4. Mentor(s), Consultants(s) and Collaborator(s) 5. Environment and Institutional Commitment to the Candidate Additional Review Consideration: 1. Training in the Responsible Conduct of Research * For Independent K awards K12 Institutional Career Development Program Overview: Program Features: Award is made to the institution. Enhance research career development for individuals, selected by the institution, who are training for careers 1, 2, or 3 years of support of Scholars in specified research areas. Salary Support: Up to legislative cap Provides institutions with a greater (varies by Institute/Center) – Most capacity and flexibility for mentoring common salary cap is $75,000 junior investigators. Duration: Up to 5 years of support for the Program Not transferable to another institution. Research Support: Up to $50,000/year (varies by Institute/Center) Usually solicited by a Funding Opportunity Announcement. Institute and Center contacts and policies: See Funding Opportunity Announcement 27 K01 Mentored Research Scientist Award Overview: Supports an intensive, supervised career development experience in the biomedical, behavioral, or clinical sciences leading to research independence. Some ICs use the K01 for individuals who propose to train in a new field or those who have had a hiatus in their research career. Some ICs utilize the K01 award to increase research workforce diversity. Primarily for PhDs or equivalent research doctoral degrees. 28 Program Features: Duration: 3 to 5 years Salary Support: Up to legislative cap (varies by Institute/Center) – Most common salary cap is $75,000 Research Support: Up to $50,000/year (varies by Institute/Center) Institute and Center contacts and policies: See Funding Opportunity Announcement K08 Mentored Clinical Scientist Award K23 Mentored Patient-Oriented Award Overview: Program Features: K08: Supports individuals with a clinical doctoral degree for a period of intensive, supervised research career development experience in the fields of biomedical and behavioral research, including translational research. Duration: 3 to 5 years K23: Supports career development of investigators who have made a commitment to patient-oriented research. Research Support: up to $50,000/year (varies by Institute/Center) Majority of awardees are MDs and MD/PhDs. Salary Support: Up to legislative cap (varies by Institute/Center) – Most common salary cap is $75,000 Institute and Center contacts and policies: See Funding Opportunity Announcement 29 K23: Qualifying Research Patient-Oriented Research is defined as research conducted with human subjects (or on material of human origin such as tissues, specimens and cognitive phenomena) for which an investigator directly interacts with human subjects. This area of research includes: Mechanisms of human disease; Therapeutic interventions; Clinical trials, and; The development of new technologies. 30 K25 Mentored Quantitative Research Award Overview: Benefits For investigators whose quantitative Duration: 3 to 5 years science and engineering research has thus far not been focused primarily on Salary Support: Up to legislative cap questions of health and disease. (varies by Institute/Center) Supports a period of supervised study and research for productive professionals Research Support: up to $50,000/year (varies by Institute/Center) with quantitative (e.g., mathematics, statistics, economics, computer science, imaging science, informatics, physics, chemistry) and engineering backgrounds to integrate their expertise with NIHrelevant research. 31 Institute and Center contacts and policies: See Funding Opportunity Announcement K22 Research Transition Award Overview: Program Features: Facilitates the transition of investigators from the mentored stage of career development to the independent stage. Duration: 2 years mentored (Intramural), followed by 3 years independent Typically, transition award for Postdocs moving to assistant professor positions. Salary Support: Up to legislative cap (varies by Institute/Center) Two Phases: Phase 1: May or may not be affiliated with an institution. Some IC’s require NIH Intramural experience Phase 2: Assistant professor with own lab and little to no teaching and administrative responsibilities. 32 – None during Intramural phase Research Support: up to $50,000/year (varies by Institute/Center) – None during Intramural phase Institute and Center contacts and policies: See Funding Opportunity Announcement K99/R00 Pathway to Independence Award Overview: 33 Program Features: To facilitate a timely transition from a K99 Phase mentored postdoctoral research – Mentored Phase: Up to 2 years position to a stable independent – Research Support: Up to research position with independent $90,000/year (most Institutes & NIH or other independent research Centers provide more funds) support at an earlier stage than is currently the norm. R00 Phase – Independent Phase: Up to 3 years; Transition award for postdocs moving 75% effort to assistant professor positions – Research Support: $249,000/year (tenure track or equivalent) Supported by almost all ICs with variations No citizenship/green card requirement Institute and Center contacts and policies: See Funding Opportunity Announcement K02 Independent Scientist Award Overview: Program Features: Duration: 3 to 5 years To foster the development of outstanding scientists and enable them to expand their potential to make significant contributions to their field of research. Salary Support: Up to legislative cap (varies by Institute/Center) – Most common salary cap is $75,000 For newly independent scientists who can demonstrate the need for a period Research Support: Most of intensive research focus as a means Institutes/Centers do not provide research costs of enhancing their research careers. Must have independent grant support as Principal Investigator (e.g. R01). Mix of PhDs and MDs. Relatively few applicants. 34 Institute and Center contacts and policies: See Funding Opportunity Announcement K24 Midcareer Investigator Award in POR Overview: Program Features: Support for mid-career health Duration: 3 to 5 years professional doctorates or equivalent who are typically at the Associate Professor Salary Support: Most Institutes and level or the equivalent for protected time Centers provide salary up to the to devote to patient-oriented research legislative cap and to act as research mentors primarily for clinical residents, clinical fellows Research Support: Most Institutes and and/or junior clinical faculty. Centers provide up to $50,000/year Typically associate professors, but can continue to support those promoted to full professor. Typically MDs. 35 Institute and Center contacts and policies: See Funding Opportunity Announcement Individual & Institutional Positions on Ks: FY 2014 5,000 Number of individuals appointed to institutional career award positions is an estimate. 4,500 Number of Positions 4,000 3,500 3,000 2,500 ~3500 (Individual) 2,000 1,500 1,000 500 ~800 (Institutional) 0 Mentored K Awards ~500 (Individual) Independent K Awards 36 Success Rate of K01 Awards Reviewed Success Rate Awarded 100% 700 90% 600 500 70% 60% 400 50% 300 40% Success Rate Applications and Awards 80% 30% 200 20% 100 10% 0% 0 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 Fiscal Year 37 Success Rate of K08 Awards Reviewed Awarded Success Rate 700 100% 80% 500 60% 400 40% 300 Success Rate Applications and Awards 600 20% 200 0% 100 0 -20% 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 Fiscal Year 38 Success Rate of K23 Awards Reviewed Awarded Success Rate 700 100% 90% 600 500 70% 60% 400 50% 300 40% Success Rate Applications and Awards 80% 30% 200 20% 100 10% 0 One Award Only 2005 0% 2006 2007 2008 2009 2010 2011 2012 2013 2014 Fiscal Year 39 Success Rate of K99 Awards Reviewed Awarded Success Rate 1,200 100% 90% 80% 70% 800 60% 600 50% 40% 400 Success Rate Applications and Awards 1,000 30% 20% 200 10% 0 0% 2007 2008 2009 2010 2011 2012 2013 2014 Fiscal Year 40 NIH New Investigators Programs National Research Service Award (NRSA) Institutional Training Grants and Individual Fellowships Research Career Development Awards New and Early-Stage Investigators 41 R03 Small Grant Program Overview: Provides limited funding for a short period of time to support a variety of types of projects, including: Pilot or feasibility studies Collection of preliminary data Secondary analysis of existing data Small, self-contained research projects Development of new technology, etc. Program Features: Limited to two years of funding Direct costs generally up to $50,000 per year Not renewable Utilized by more than half of the NIH Institutes and Centers Institute and Center contacts and policies: See Funding Opportunity Announcement 42 Academic Research Enhancement Award (R15) Overview: Supports small-scale research projects in the biomedical and behavioral sciences conducted by faculty and students at educational institutions that have not been major recipients of NIH research grant funds. Goals of the Program: Support meritorious research Expose students to research Strengthen the research environment of the institution Program Features: Project period is limited to 3 years. Direct costs are limited to $300,000 over the entire project period. Grants are renewable. Preliminary data are not required. Institute and Center contacts and policies: See Funding Opportunity Announcement [email protected] 43 Exploratory/Developmental Research (R21) Overview: Encourages new, exploratory and developmental research projects by providing support for the early stages of project development. Sometimes used for pilot and feasibility studies. Preliminary data are not required but may be included if available. Limited to up to two years of funding. Program Features: Combined budget for direct costs for the two year project period usually may not exceed $275,000 No preliminary data is generally required Most Institutes and Centers utilize the R21 program Institute and Center contacts and policies: See Funding Opportunity Announcement 44 New and Early-Stage Investigators Becoming an independent research is taking longer and longer Bridges to Independence: Fostering the Independence of New Investigators in Biomedical Research (2005) Age at First R01 Equivalent Award from NIH: FY 1980-2009 Concerns have been raised for decades about scientists spending long periods of time as postdoctoral appointees, unable to set their own direction 45 New and Early-Stage Investigators NIH is finding new methods to encourage funding (and hiring) of early-stage investigators Revised New and Early Stage Investigator Policies (NOT-OD-09013)` Goal of funding new investigators at same rate as established investigators submitting new projects Support outstanding earlystage Investigators as they pursue high risk/high reward research A new program to allow exceptional young investigators to “skip” the post-doc! 46 Definition of New Investigator A PD/PI who has not previously competed successfully for a significant NIH independent research award, other than the following awards: Research Project Grants: R00, R03, R15, R21, R25, R90, (RL9, RL5), R34, R36, (R41, R43), R55, R56, SC2, SC3 All training Grants: T32, T34, T35, T90, D43 All Fellowships: F awards Mentored Career Awards: All individual and institutional mentored K awards Loan repayment contracts: L30, L32, L40, L50, L60 Instrumentation, Construction, Education, Health Disparity Endowment Grants, or Meeting Awards: G07, G08, G11, G13, G20, R13, S10, S15, S21, S22 47 Definition of Early Stage Investigator A PD/PI who qualifies as a New Investigator is considered an Early Stage Investigator if he/she is within 10 years of completing his/her terminal research degree or is within 10 years of completing medical residency (or the equivalent). Implementing the Early Stage Investigator Policy: eRA Commons profiles include degree and residency completion dates Encouraging early transition to research independence: Modifying the NIH New Investigator policy to identify Early Stage Investigators Can request an extension of the Early Stage Investigator Period 48 New Investigator Initiatives New Investigators receive special attention at Council as high program priority or equivalent. Increased payline for scored R01 applications from New Investigators. No imposed reductions in duration and amount of awards (beyond the recommendations of the initial review group) for New Investigators. Fund applications to achieve a designated success rate rather than setting a specific payline for New Investigators applying for R01s. 49 NIH Director’s New Innovator Award Support creative new investigators with highly innovative research ideas at early career stages. No preliminary data required. Evaluate pre-application—Invite full application. Potential for significant impact on an important biomedical or behavioral research problem. Applicants must hold independent research position at a domestic institution. Doctoral degree or completed internship/residency within past 10 years. Must commit at least 25% of research effort. There are no citizenship or residency requirements. 50 NIH Director’s Early Independence Award A new program to allow exceptional young investigators to “skip” the post-doc! “For the most creative of young scientists, nothing can equal the chance to have a lab of one's own.” Francis Collins, Nature, 2010 Inspired in some respects by programs at Carnegie, Whitehead, UCSF, and other institutions showing that exceptional individuals do not require a post-doc to undertake pioneering research. Solicited and incorporated input from research community. First year will be a pilot (~10 awards) to test ideas and process, but may be scaled up in subsequent years. Program Features: An institution may submit up to two applications Awards will be up to $250K per year (direct costs) for up to 5 years 51 NIH Director’s Early Independence Award (EIA) New PhD or MD locates an institution willing to host them for an EIA • Must be within 12 mo. before or after graduation • Must demonstrate exceptional creativity, maturity, management skills • Research relevant to NIH mission • Strong letters of recommendation Institution may actively recruit eligible EIA candidates •Institution ensures independent lab space/supplies/space/equipment •Appointment up to 5 yrs •Protected research time for development as researcher •Proposed research complements and enhances institution’s programs •Institution may choose to retain candidate 52 NIH Office of Extramural Research Resources: NIH Extramural Training Mechanisms: http://grants1.nih.gov/training/extramural.htm Ruth L. Kirschstein National Research Service Award (NRSA): http://grants1.nih.gov/training/nrsa.htm NIH Career Development Awards: http://grants1.nih.gov/training/careerdevelopmentawards.htm Types of Grant Programs: http://grants.nih.gov/grants/funding/funding_program.htm 53