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5th Annual Institute on Postdoctoral Preparation September 26, 2008

NIH Funding Mechanisms for Postdoctoral Fellows

Henry Khachaturian, Ph.D.

NIH Extramural Program Policy Officer Acting NIH Research Training Officer Office of Extramural Research, NIH Email: [email protected]

NIH Institutes and Centers (IC)

FY 2008 Enacted Budget: $29.457 Billion

Research Mgmt & Support: 5% All Other: 2% Other Research: 6% Research Training: 3% Research Centers: 10% R&D Contracts: 11% Intramural Research: 10%

$761 $696 Training Career $1,457 Million

Research Project Grants: 53%

Research Training and Career Timetable

Ruth L. Kirschstein National Research Service Award (NRSA) Program Research Career Development Award (K) Program Undergraduate Grad or Med School Postdoc or Residency Principal Investigator Team Scientist Extramural Loan Repayment Program (LRP)

Fellowships and Training Grants

Individual Predoc Fellowship (F31) Individual Postdoc Fellowship (F32) Undergraduate Grad or Med School Postdoc or Residency Principal Investigator Team Scientist Institutional Training Grant (T32)

Training Grants and Fellowships for FY 2006

14,000 13,000 12,000 11,000 10,000 9,000 8,000 7,000 6,000 5,000 4,000 3,000 2,000 1,000 0 5,519 (41%) Postdocs 8,097 (59%) Predocs Training Grants 1,600 (54%) Postdocs 1,370 (46%) Predocs Fellowships

Individual NRSA Postdoc Fellowship (F32)

    

Individual Fellow applies through University/Institution

Training support based on research & training plans and potential to become an independent investigator Up to 3 years of support; second year repays service payback obligation.

Stipend: Not salary; subsistence allowance to help defray living expenses Fellow not an employees of either Government or University Current stipend levels based on Years of experience: 0 = 1 = 2 = 3 = 4 = 5 = 6 = 7 = $36,996 $38,976 $41,796 $43,428 $45,048 $46,992 $48,852 $51,036

Tuition, Fees, and Health Insurance

Individual Fellowships Predoctoral Postdoctoral

Tuition/Fees Formula: • 60% up to $16,000 • 60% up to $21,000 for dual-degree • 60% up to $4,500 • 60% up to $16,000 for those seeking additional degree Institutional Allowance* • Public/Private Inst.

• Fed./For Profit Inst.

$4,200 $3,100 $7,850 $6,750 * Help defray costs such as research supplies, equipment, Health Insurance, fellow’s travel to scientific meetings and appropriate administrative costs.

F32 Fellowship Application

 

Use PHS 416-1:

Paper Application

Transition to electronic application

: Anticipated for August 2009 

Application Submission Dates:

• April 8, August 8, December 8 

Two-level review:

• Evaluation by Study Section (Peer Review) • Evaluation by Institute Program Staff • Generally 5-6 month period from receipt to earliest possible award • Check Program Announcements for variations

Fellowship Review Criteria

   

Candidate:

Previous and current academic and research performance; Potential, and commitment to biomedical research career

Sponsor/Mentor and Training Environment:

Quality of environment and institutional commitment to training; Availability of facilities/resources; and funding; Qualifications of mentor/sponsor for proposed research training, and successful competition for research support

Research Training Proposal:

Merit of the proposal; Quality of research training plan; Training as foundation for candidate’s productive career

Training Potential:

Value of the proposed fellowship experience as it relates to the candidate's needs in preparation for a career as an independent researcher

Helpful Hints for Fellowships

        

Read the Program Announcement and Contact NIH staff

Read the Instructions in the application kit Observe Page limitations Give yourself and your sponsor enough time Give references enough time Same training site?

Training should be appropriate considering previous experience Capable and experienced sponsor? Co-sponsor?

Project should have merit as research and as training mechanism  Arrange for pre-review

Research Career Development Awards

Undergraduate Grad or Med School Mentored Scientist Career (K01) Mentored Clinical Scientist Career (K08) Pathway to Independence (K99/R00) Postdoc or Residency Mentored Patient Oriented Career (K23) Quantitative Career Award (K25) Principal Investigator Team Scientist Independent Scientist (K02) Midcareer Patient Oriented (K24) Senior Scientist Award (K05)

Career Awards for FY 2006

4,000 3,000 2,000

3,721 Individual Awards

1,000

207 Institutional Awards

0

Early (Mentored) 234 Individual Awards Mid-Career 79 Individual Awards Senior

Common Features: Eligibility

Who can Apply?

 Read Program Announcements carefully  Research doctoral degree (

K01, K02

), but some require clinical doctoral degree (

K08, K23

)  US Citizens, Non-Citizen Nationals, Permanent Residents (except

K99/R00

)  Previous NIH Principal Investigators may be Ineligible  Usually Principal Investigator on

R03

or

R21

is OK (except

K99/R00

)  Principal Investigator on

R01

or subproject Principal Investigators on a

P01

is not OK

Common Features: Duration

Three, Four, or Five years

 depending on mechanism and justification of need  Extensions in time – award terms remain in effect (i.e. minimum effort, no salary from other federal funding source)  Entry level awards require a mentor, multiple mentors are encouraged  Mentored K awardees are encouraged to apply for independent support during the K award

Common Features: Effort

  

At least 75% effort committed to research

and the rest on other career development activities

Policy:

Awardee must have a full-time appointment (12 person months) at applicant institution, and the minimum effort requirement must be covered by that appointment 

Policy Update:

Mentored K awardees in final 2 years may reduce effort (to minimum of 50%) on K if replaced by effort as Principal Investigator on research project or subproject of Center grant, provided they remain in mentored situation  Temporary reduction permissible in unusual and pressing circumstances

Common Features: Costs

  

Vary widely across NIH Institutes and Centers

Read specific announcements carefully Salaries capped between $75,000 and legislated cap ($191,300 for FY 2008)   Fringe benefits are in addition to any cap, plus 8% F&A costs Salary supplementation OK, but must be from non-Federal sources and must not require extra duties that would interfere with K activities  Research costs: Generally $25,000 to $50,000 and commonly used for supplies, equipment, technical personnel, travel to research meetings or training, tuition/fees, computational services  Ancillary personnel support is not allowed, such as salary for administrative/secretarial support, support for mentors

Common Features: Application

Use PHS Form 398:

Career Award Section 

Transition to electronic application

: Anticipated for February 2009 

Application Submission Dates:

• February 12, June 12, October 12  See also special instruction in a particular Funding Opportunity Announcement  Institutes and Centers use of career awards is highly variable! So… read the announcement carefully and call the NIH staff!

 In K announcements, see contact web-table in for participating Institutes and Centers

K01: Option for Research Doctorates

Provides an intensive, mentored research experience for a period of up to 5 years

  Minimum of 75% full-time professional effort is required (based on 12 person months appointment) Candidates must have a research doctorate and postdoctoral experience    Caution: Not an extension of postdoctoral training!

Varied and limited NIH Institute and Center (IC) participation • Some ICs use for re-entry • Some ICs use to pursue new research area Requires plan for independence

K08: Option for Health Prof. Doctorates

Supervised research experience for individuals who are committed to a career in laboratory or field-based research

 Minimum of 75% full-time professional effort is required (based on 12 person months appointment)  Candidates must have a health professional doctorate, but may or may not have postdoctoral experience  Potential for phased award periods: • didactic experience • “hands-on” research experience  Usually supports non-patient-oriented research

K23: Option for Patient-oriented Research

Supervised study and research career development for clinically trained professionals with a commitment to patient oriented research

 Minimum of 75% full-time professional effort is required (based on 12 person months appointment)  Candidates must have a health professional doctorate, but may or may not have postdoctoral experience  Must have completed clinical training, (including specialty and sub-specialty if applicable) prior to award   May submit application prior to completion of clinical training Patient-Oriented defined as research conducted with human subjects, or material of human origin such as tissues, specimens

K25: Option for Quantitative Scientists

Mentored experiences for scientists from quantitative and engineering backgrounds interested in pursuing health related research

 Minimum of 75% full-time professional effort is required (based on 12 person months appointment)  Candidates must have a research doctorate and ideally some postdoctoral experience  Unique among NIH K awards in that eligibility spans the postdoctoral to senior faculty levels, although some Institutes have exceptions to this general rule

K99/R00: Option for Career Transition

Provides up to 5 years of support in two distinct phases: Mentored and Non-Mentored

  K99 phase: Mentored research experience for up to 2 years R00 phase: Independent scientist phase for transition to independence as junior faculty (up to 3 years)  Applicants may have no more than 5 years of postdoctoral training at the time of initial application or any resubmissions  K99 is unique among NIH K awards in that both U.S. citizens and non-U.S. citizens may apply   Domestic institutions only (both phases) Transition to R00 phase requires offer and acceptance of tenure track, full-time assistant professor position, or equivalent

Common “K” Review Criteria (1 of 3)

Candidate:

Potential to develop as an independent and productive researcher; Quality of the letters of reference; Mentor(s) Statement 

Career Development Plan:

Likelihood that plan will contribute substantially to the scientific development of candidate leading to scientific independence 

Research Plan:

Scientific and technical merit of the research question; Relevance to candidate's career objectives 

Statements by Mentor(s), Consultant(s), and Collaborator(s):

Mentor's qualifications in proposed research; Role in providing guidance to the candidate; Previous experience and history of research productivity 

Environment and Institutional Commitment to the Candidate:

Commitment of institution to ensure that a minimum of 75% of the candidate's effort will be devoted directly to research

Helpful Hints for “K” Applicants

Read the Program Announcement carefully and contact NIH Program staff

     Call NIH Program Staff Read the Instructions in the application kit Give yourself and your mentor(s) enough time Give your references enough time Training or career development plan should be appropriate considering previous experience   Capable and experienced mentor/sponsor? Co-sponsor?

Project should have merit as research and as training or career development vehicle  Arrange for pre-review

Transition to Electronic Applications

February 12, 2009:

Research Career Development (all Ks except K12) 

August 8, 2009:

Individual National Research Service Awards (F) 

September 25, 2009:

Institutional National Research Service Awards and Other Training Grants (T, D), D43, D71/U2R and K12