Transcript NIH Grant Project ChemEng 590B 2/21/13 Outline of Project 1. Come up with a creative tissue engineering topic to study, advance, and present via.

NIH Grant Project
ChemEng 590B
2/21/13
Outline of Project
1. Come up with a creative tissue engineering topic to
study, advance, and present via an NIH-style grant and
class presentation.
2. 3 groups of 4: after everything is graded: 50% of your
individual, final grade.
3. Project involves 4 major parts:
1. A grant review panel, April 2nd, in class (10%)
2. A specific aims page, which introduces me to your
proposed topic, due April 11th (10%)
3. A full paper grant, that must adhere to the guidelines for
an NIH R03, R21, or R01 mechanism, due April 23rd (20%)
4. A presentation (sales pitch!) on your tissue engineering
idea in front of the class. 2 days of presentations: April
23rd and 25th, in class. (10%)
Groups (I have pre-assigned you)
Group 1: April 23rd
Ryan Colombo, Matthew Osso, Stephanie Polgar, Julia Tomaszewski
Group 2: April 23rd
Lenny Brandon, Chris Carr, Manuel Escanciano, Timothy Ma
Group 3: April 25th
Matthew McNulty, Adam Ramey, Kyle Reed, Anthony Valle
ALL PAPERS DUE ON APRIL 23RD
How does one create a new idea?
• Lectures and Readings: ideas we discuss in
class
– Stem cells for building new replacement tissue
– Driving or studying cell movement, growth,
differentiation
– Driving or studying cell-cell and cell-matrix
interactions
– Disease specific!
– I HIGHLY RECOMMEND: you come talk to me in
office hours about the feasibility of your idea
• New literature research: Library Resources
3 Grant Types to Choose From (NIH)
•
•
These are your choices for style
R03, http://grants.nih.gov/grants/guide/pa-files/PA-10-064.html
– discrete, well-defined projects that realistically can be completed in two years and that require limited
levels of funding ($50,000 per year)
– Pilot or feasibility studies
– Secondary analysis of existing data
– Small, self-contained research projects
– Development of research methodology
– Development of new research technology
– research plan is restricted to 6 pages
•
R21, http://grants.nih.gov/grants/guide/pa-files/pa-10-069.html
– introduction of novel scientific ideas, model systems, tools, agents, targets, and technologies that have the
potential to substantially advance biomedical research
– new exploratory and developmental research projects (Think: high-risk)
– Also a two-year grant, at $275,000 over two years.
– unique and innovative use of an existing methodology to explore a new scientific area
– may involve considerable risk but may lead to a breakthrough in a particular area
– should break new ground or extend previous discoveries toward new directions or applications
•
R01, http://grants.nih.gov/grants/guide/pa-files/pa-10-067.html
– the original and historically the oldest grant mechanism used by the NIH to support health-related
research and development
– Large research projects, involving multiple students, and often multiple PIs
– Anywhere from 2-5 years, at a maximum of $250,000 per year.
– Must also be innovative and novel, but not necessarily high-risk. i.e. your preliminary data, literature
knowledge, and other expertise makes it seem that you will definitely be able to complete all objectives
– Major cash-cows of big research labs.
Your NIH Grant MUST Include:
• Go here for formatting (margins, font size, etc.):
http://grants.nih.gov/grants/funding/424/index.htm
• Biosketch for each team member.
• Research Plan.
– 1 Page: Specific Aims.
– 6 Pages (R03 and R21), or 12 Pages (R01), including:
• Significance (background, relevance to human health)
• Innovation (why it’s so novel, creative, what it will lead to)
• Approach (research methods planned), and including Preliminary
Data
• Optional idea: Benchmarks for success
• Optional idea: potential pitfalls and solutions
• Optional idea: Future directions
• Optional idea: Timeline
– References (not part of page limit)
Grant Review Day: 10%
• In class, we will spend 1 lecture acting like a grant panel (April 2nd).
• I have 3 of last year’s grants. Everyone in class can see each of the 3 grants.
(posted online)
• Each group has been formally assigned to review just one of these grants.
• Before class (April 2nd), each member of the group should independently
prepare ~1 page of notes (that you won’t turn in), that include the pros and
cons of the grant idea.
• Each person should bring a copy of the grant as well to facilitate discussion.
• In class, we will go through each grant. For the grant you are officially
assigned, you will talk, in class, from your seat, for about 5min, giving a
short summary of what was good and bad about the grant.
• During this discussion, anyone in class can comment, but you’re only
required to talk about the grant you were assigned.
• Within your group, assign one person to be the “scribe” for the group.
During the discussion, the scribe will take notes on their laptop about what
was discussed about the grant. This will be read aloud, at the end of the
lecture, to the whole group. Please email me this summary page for your
grade by midnight, April 2nd (same day). I’m looking for how detailed your
reviews were. The summary should be no more than 1 page!
• Use this review to help you write your own grants!
Specific Aims Page: 10%
• Due April 11th, in class
– 1 page introduction of project. No more than 1
page!
– It’s a good idea to come talk to me about your
idea before you write this up and turn it in.
– I have an example of a funded specific aims page
(handout)
– You can modify this after the graded feedback,
because you will turn it in again with your final
grant.
Note about Presentation Dates
• Dates: April 23rd and 25th
• Remember, this is a sales pitch for your idea.
• You need to get across:
– The human health problem is real and needs novel
solutions, approaches
– The literature backs up the fact that your idea will
work
– That your idea is awesome and novel
– That your idea will work if you are funded! (find
preliminary data from the literature)
• Everyone must be at all the presentations.
Groups will be partly graded by classmates, and
turning your evaluation of the other groups is
mandatory.
The most important thing you can do is…..
1. Proofread. Not just you, but get it done
early and send to a peer. They can catch
mistakes that you will miss.
1. Come talk to me!! This is what office hours
are for. Send a group member (or even
better, all of you) to talk to me once a week.
I will give you critical feedback. Better during
office hours then on your grade!
a) I can also show you examples of my grants to
help you with organization.