Transcript MORPHOLOGICAL FEATURES OF BANDS False Colorization “Gradient Map” Reveals Mini-features 67 MW band LOWER BANDS SHOW NO SIMILARITY 32 MW band.

MORPHOLOGICAL
FEATURES OF
BANDS
False Colorization “Gradient Map” Reveals Mini-features
67 MW
band
LOWER
BANDS
SHOW NO
SIMILARITY
32 MW
band
Page 1
Use of the Image Overlay procedure
Immunity, Figure 1
panel1
panel 2
panel 3
panel 4
panel 5
panel 6
questioned panels
Figure 1 (panel 5 vs 6)
panel 6 (black) is a subset of panel 5 (red)
red and black = unique
blue = overlap
no overlap
panel 5 vs 2
panel 5 vs 4
What can you do at your
institution?
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You can help set the tone for the institution and
make integrity a high priority
As an administrator, you can develop and
implement policies that support integrity
As a principal investigator, you can establish
specific standards for your staff on recording,
retaining, reporting, and publishing data
As a junior scientist in the lab, you can make a
personal commitment to integrity and practice it
on a daily basis
Responsible Conduct of
Research (RCR)
What can ORI and institutions do
to help prevent research
misconduct?
The Nine Elements of RCR
1. Acquisition, management, sharing and ownership of
data
2. Conflict of interest and commitment
3. Research misconduct (plagiarism, falsification &
fabrication)
4. Publication practices and responsible authorship
5. Mentor/mentee responsibilities
6. Peer review
7. Collaborative scholarship
8. Human subjects
9. Animal subjects
RCR at the Individual Level
encompasses:
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Intellectual honesty in proposing,
performing, and reporting research
Accuracy in representing contributions
Fairness in peer review
Transparency in conflicts of interest
RCR at the Individual Level also
entails:
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Assuming personal responsibility for
avoiding or managing conflicts
Taking responsibility for protecting human
subjects and for the humane care of
animals
Appropriately recording research results
and retaining research records
Careful and thoughtful mentoring of
students and junior scientists
How can RCR be implemented
at the institutional level?
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Provide leadership in RCR
Facilitate productive interactions between
trainees and mentors
Advocate adherence to rules regarding the
conduct of research
Provide training to both mentors, junior
scientists, and students tailored to their
respective needs
RCR at the Institutional level (cont.)
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Conduct inquiries and investigations into
alleged misconduct
RCR training should include discussions of
misconduct cases and their adverse
consequences to respondents
Consider publicizing your cases (suitably
redacted) to ensure that staff realize that
you take misconduct seriously and act on
allegations
A few key issues that DIO has found
contribute most significantly to allowing
misconduct
1. Inadequate record keeping and lack of
guidance from mentors on how to record and
retain research data;
2. Failure of mentors to regularly review raw
data; overreliance on derivative data
(PowerPoint presentations) at lab meetings
3. Unquestioning acceptance of data that others
consider “too good to be true”
More issues that facilitate misconduct
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4. Lack of transparency within the laboratory and
among the staff
5. Labs so large that authority becomes diffuse
6. P.I.s are spread too thin, and do not provide
adequate training and guidance to students
The bottom line – good mentorship and the constant
review of raw data can profoundly reduce the
likelihood of a mentee committing research
misconduct.
ORI can provide assistance
240 453 8800; [email protected]
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Telephone or on site assistance available
Allegation assessment
Advice on policies and procedures, for example :
 Sequestration of evidence
 Acquisition of digital information (forensic imaging of
hard drives)
Properly getting an inquiry or investigation under way
Analysis of the evidence, such as assisting with analysis
of questioned images
Investigative strategy and legal problems
Conclusion
DEVELOP AN RCR PROGRAM THAT
WORKS FOR YOU!
http://ori.hhs.gov