Emerging and Dangerous Pathogens Laboratory Network (EDPLN) Dr Renu Drager-Dayal, WHO Geneva Global Alert and Response.
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1 Emerging and Dangerous Pathogens Laboratory Network (EDPLN) Dr Renu Drager-Dayal, WHO Geneva Global Alert and Response EDPLN Network Development EDPLN successful outcome of two informal consultations, the first in Libreville, Gabon, in March 2008, and the second at WHO Headquarters in Geneva in February 2009. BSL-4/BSL-3 human and veterinary laboratories able and willing to collaborate and cooperate, and share their knowledge, biological materials and experimental research results in real time to detect, diagnose and control novel disease threats. 25 Laboratories, 18 countries, 6 WHO regions Global Alert and Response EDPLN Network Goal Network of BSL-4/BSL-3 human and veterinary laboratories intended: to support the diagnostic functions for laboratory response to global epidemic threats of new, emerging and dangerous pathogens (Ebola, Marburg and other VHFs, SARS, Nipah, etc.) to build capacity and transfer technology for safe and appropriate diagnostics to regional networks and countries in the zones of emergence to enhance earlier outbreak detection and faster and better management; to provide surge capacity in response to epidemic activity that is geographically distributed or has the potential to become a global threat. Global Alert and Response 5 Ebola Outbreaks Nature Medicine 11, 720 - 721 (2005) EDP Outbreak Control Strategy and Functions Traditional healers COMBI * Posters Radio - TV Discussion Community Social Mobilization Health Education Risk Communication Media Information Lodging alimentation Roads police Barrier nursing Medical Anthropology Psycho Social support Mobile teams Epi + Soc Finances salaries Transports Vehicles (* COMBI = communication for behavior change) Global Alert and Response Case Management Death Audits, Funerals Infection Control Intersectoral Coordination Political leadership Logistics Security Communications Triage IN / OUT Clinical trials Outpatient Water and Sanitation Environment Vector Control Epidemiological Investigation Surveillance Laboratory Database analysis Ecology Human-animal Follow-up of cases Active search for cases Analysis Samples Results Ebola outbreak response : Laboratory PCR Ebola Heinz Feldmann LCDC Laboratory Congo Mbomo 2003 Global Alert and Response Ebola HF outbreak response, Mweka, DRC. Global Alert and Response Technical Networks coordinated with GOARN COMBI (Health education) EDPLN (BSL4 laboratories) Clinical GOARN Global Alert and Response Clinical Network EDP Laboratory Network Mathematical Modelling Network Infection Control Network Behaviour Change/Social Mobilisation Network EDPLN Structure Secretariat EDPLN Working Groups: • Laboratory Outbreak Response • Assay and Reagent Development • Technology Transfer and Training • International Engagement Laboratory Outbreak Response EDPLN - Biosafety / biosecurity - Shipment of dangerous goods • Applied Research Global Alert and Response Assay and Reagent Development Applied Research International Engagement Technology Transfer and Training Laboratory participation in WHO AFRO EDPLN-AFRICA Workshop Cape Town 11 -12 December 2010 IP-Senegal Kenema-Sierra Leone I-CAR IP-Côte-d'Ivoire IP-Cameroon CIRMF-Gabon UVRI-Uganda INRB-DRC KEMRI-CDC International Labs NML/Canada RKI/Germany NIH/USA Reference BSL4 BSL3 labs with VHF diagnostic capacity BSL3 and BSL2 labs with some VHF diagnostic capacity IP-Madagascar NICD-South Africa Global Alert and Response 12 Different post-exposure treatment options VSV (50% ZEBOV in Rhesus at 30 min). siRNA (100% ZEBOV in Rhesus at 30 min). Monoclonal against coagulation (67% ZEBOV in Rhesus at 24 hours). 13 Expression of ZGP by Western blot 14 Acknowledgments PHAC CFIA Ami Patel Kaylie Tran Mike Gray Gregory Schumer Jason Richardson Gary Wong Allan Chand Alexander Bello Anders Leung Darryl Falzarano Hana Weingartl James Neufeld Greg Smith Kevin Tierney _______________________________ Jim Strong Darwyn Kobasa Wildlife Conservation Society Ken Cameroun University of Texas at Austin Maria Croyle Joe Dekker National Research Council Amine Kamen Rocky Mountain Laboratories Heinz Feldmann Hideki Hebihara