Slide 1

Feline post-traumatic ocular
sarcoma

Anya C. Hawthorn, MS, DVM*
D. Phillip Sponenberg, DVM, PhD

Acknowledgements
• Histology:
– Luther Vest
– Barbara Wheeler
– Jill Songer

• Sub-gross
photography
– Jerry Baber

Signalment and History
• 17 year old FS DSH
• Respiratory distress
• Mucopurulent nasal
discharge
• Missing upper canine
•“Lost” right eye 8 years ago
• Unresponsive to antibiotics

Gross Findings

PAS

Feline post-traumatic ocular
sarcoma
• associated with a past history of traumatic lens
rupture
• believed to arise from lens epithelium or ciliary body
• develop 1 to 10 years after the initial injury
• locally invasive, may metastasize, and carry a poor
prognosis
• Vimentin positive, cytokeratin negative, and
frequently produces PAS positive material similar to
lens capsule

References
• 1. Zeiss, CJ, E.M. Johnson. R.R. Dubiezig. 2003. Feline
Intraocular Tumors May Arise from Transformation of Lens
Epithelium. Veterinary Pathology. 40:355-362.
• 2. Meuten, D.J. 2002. Tumors in domestic Animals, 4th Ed.
Iowa State Press, Ames, Iowa.
• 3. Grahn, B.H., R.L. Peiffer, C.L. Cullen, D.M. Heins. 2006.
Classification of feline intraocular neoplasms based on
morphology, histochemical staining, and
immunohistochemical labeling. Veterinary Ophthalmology. 9,
6:395-403.
• 4. F. Jelinek. 2003. Postinflammatory sarcoma in cats.
Experimental and Toxicologic Pathology. 55: 167-172.

Questions
• Relation to feline
post-vaccine
sarcomas?
• What about the
feline chronic
inflammatory
response is
oncogenic?


Slide 2

Feline post-traumatic ocular
sarcoma

Anya C. Hawthorn, MS, DVM*
D. Phillip Sponenberg, DVM, PhD

Acknowledgements
• Histology:
– Luther Vest
– Barbara Wheeler
– Jill Songer

• Sub-gross
photography
– Jerry Baber

Signalment and History
• 17 year old FS DSH
• Respiratory distress
• Mucopurulent nasal
discharge
• Missing upper canine
•“Lost” right eye 8 years ago
• Unresponsive to antibiotics

Gross Findings

PAS

Feline post-traumatic ocular
sarcoma
• associated with a past history of traumatic lens
rupture
• believed to arise from lens epithelium or ciliary body
• develop 1 to 10 years after the initial injury
• locally invasive, may metastasize, and carry a poor
prognosis
• Vimentin positive, cytokeratin negative, and
frequently produces PAS positive material similar to
lens capsule

References
• 1. Zeiss, CJ, E.M. Johnson. R.R. Dubiezig. 2003. Feline
Intraocular Tumors May Arise from Transformation of Lens
Epithelium. Veterinary Pathology. 40:355-362.
• 2. Meuten, D.J. 2002. Tumors in domestic Animals, 4th Ed.
Iowa State Press, Ames, Iowa.
• 3. Grahn, B.H., R.L. Peiffer, C.L. Cullen, D.M. Heins. 2006.
Classification of feline intraocular neoplasms based on
morphology, histochemical staining, and
immunohistochemical labeling. Veterinary Ophthalmology. 9,
6:395-403.
• 4. F. Jelinek. 2003. Postinflammatory sarcoma in cats.
Experimental and Toxicologic Pathology. 55: 167-172.

Questions
• Relation to feline
post-vaccine
sarcomas?
• What about the
feline chronic
inflammatory
response is
oncogenic?


Slide 3

Feline post-traumatic ocular
sarcoma

Anya C. Hawthorn, MS, DVM*
D. Phillip Sponenberg, DVM, PhD

Acknowledgements
• Histology:
– Luther Vest
– Barbara Wheeler
– Jill Songer

• Sub-gross
photography
– Jerry Baber

Signalment and History
• 17 year old FS DSH
• Respiratory distress
• Mucopurulent nasal
discharge
• Missing upper canine
•“Lost” right eye 8 years ago
• Unresponsive to antibiotics

Gross Findings

PAS

Feline post-traumatic ocular
sarcoma
• associated with a past history of traumatic lens
rupture
• believed to arise from lens epithelium or ciliary body
• develop 1 to 10 years after the initial injury
• locally invasive, may metastasize, and carry a poor
prognosis
• Vimentin positive, cytokeratin negative, and
frequently produces PAS positive material similar to
lens capsule

References
• 1. Zeiss, CJ, E.M. Johnson. R.R. Dubiezig. 2003. Feline
Intraocular Tumors May Arise from Transformation of Lens
Epithelium. Veterinary Pathology. 40:355-362.
• 2. Meuten, D.J. 2002. Tumors in domestic Animals, 4th Ed.
Iowa State Press, Ames, Iowa.
• 3. Grahn, B.H., R.L. Peiffer, C.L. Cullen, D.M. Heins. 2006.
Classification of feline intraocular neoplasms based on
morphology, histochemical staining, and
immunohistochemical labeling. Veterinary Ophthalmology. 9,
6:395-403.
• 4. F. Jelinek. 2003. Postinflammatory sarcoma in cats.
Experimental and Toxicologic Pathology. 55: 167-172.

Questions
• Relation to feline
post-vaccine
sarcomas?
• What about the
feline chronic
inflammatory
response is
oncogenic?


Slide 4

Feline post-traumatic ocular
sarcoma

Anya C. Hawthorn, MS, DVM*
D. Phillip Sponenberg, DVM, PhD

Acknowledgements
• Histology:
– Luther Vest
– Barbara Wheeler
– Jill Songer

• Sub-gross
photography
– Jerry Baber

Signalment and History
• 17 year old FS DSH
• Respiratory distress
• Mucopurulent nasal
discharge
• Missing upper canine
•“Lost” right eye 8 years ago
• Unresponsive to antibiotics

Gross Findings

PAS

Feline post-traumatic ocular
sarcoma
• associated with a past history of traumatic lens
rupture
• believed to arise from lens epithelium or ciliary body
• develop 1 to 10 years after the initial injury
• locally invasive, may metastasize, and carry a poor
prognosis
• Vimentin positive, cytokeratin negative, and
frequently produces PAS positive material similar to
lens capsule

References
• 1. Zeiss, CJ, E.M. Johnson. R.R. Dubiezig. 2003. Feline
Intraocular Tumors May Arise from Transformation of Lens
Epithelium. Veterinary Pathology. 40:355-362.
• 2. Meuten, D.J. 2002. Tumors in domestic Animals, 4th Ed.
Iowa State Press, Ames, Iowa.
• 3. Grahn, B.H., R.L. Peiffer, C.L. Cullen, D.M. Heins. 2006.
Classification of feline intraocular neoplasms based on
morphology, histochemical staining, and
immunohistochemical labeling. Veterinary Ophthalmology. 9,
6:395-403.
• 4. F. Jelinek. 2003. Postinflammatory sarcoma in cats.
Experimental and Toxicologic Pathology. 55: 167-172.

Questions
• Relation to feline
post-vaccine
sarcomas?
• What about the
feline chronic
inflammatory
response is
oncogenic?


Slide 5

Feline post-traumatic ocular
sarcoma

Anya C. Hawthorn, MS, DVM*
D. Phillip Sponenberg, DVM, PhD

Acknowledgements
• Histology:
– Luther Vest
– Barbara Wheeler
– Jill Songer

• Sub-gross
photography
– Jerry Baber

Signalment and History
• 17 year old FS DSH
• Respiratory distress
• Mucopurulent nasal
discharge
• Missing upper canine
•“Lost” right eye 8 years ago
• Unresponsive to antibiotics

Gross Findings

PAS

Feline post-traumatic ocular
sarcoma
• associated with a past history of traumatic lens
rupture
• believed to arise from lens epithelium or ciliary body
• develop 1 to 10 years after the initial injury
• locally invasive, may metastasize, and carry a poor
prognosis
• Vimentin positive, cytokeratin negative, and
frequently produces PAS positive material similar to
lens capsule

References
• 1. Zeiss, CJ, E.M. Johnson. R.R. Dubiezig. 2003. Feline
Intraocular Tumors May Arise from Transformation of Lens
Epithelium. Veterinary Pathology. 40:355-362.
• 2. Meuten, D.J. 2002. Tumors in domestic Animals, 4th Ed.
Iowa State Press, Ames, Iowa.
• 3. Grahn, B.H., R.L. Peiffer, C.L. Cullen, D.M. Heins. 2006.
Classification of feline intraocular neoplasms based on
morphology, histochemical staining, and
immunohistochemical labeling. Veterinary Ophthalmology. 9,
6:395-403.
• 4. F. Jelinek. 2003. Postinflammatory sarcoma in cats.
Experimental and Toxicologic Pathology. 55: 167-172.

Questions
• Relation to feline
post-vaccine
sarcomas?
• What about the
feline chronic
inflammatory
response is
oncogenic?


Slide 6

Feline post-traumatic ocular
sarcoma

Anya C. Hawthorn, MS, DVM*
D. Phillip Sponenberg, DVM, PhD

Acknowledgements
• Histology:
– Luther Vest
– Barbara Wheeler
– Jill Songer

• Sub-gross
photography
– Jerry Baber

Signalment and History
• 17 year old FS DSH
• Respiratory distress
• Mucopurulent nasal
discharge
• Missing upper canine
•“Lost” right eye 8 years ago
• Unresponsive to antibiotics

Gross Findings

PAS

Feline post-traumatic ocular
sarcoma
• associated with a past history of traumatic lens
rupture
• believed to arise from lens epithelium or ciliary body
• develop 1 to 10 years after the initial injury
• locally invasive, may metastasize, and carry a poor
prognosis
• Vimentin positive, cytokeratin negative, and
frequently produces PAS positive material similar to
lens capsule

References
• 1. Zeiss, CJ, E.M. Johnson. R.R. Dubiezig. 2003. Feline
Intraocular Tumors May Arise from Transformation of Lens
Epithelium. Veterinary Pathology. 40:355-362.
• 2. Meuten, D.J. 2002. Tumors in domestic Animals, 4th Ed.
Iowa State Press, Ames, Iowa.
• 3. Grahn, B.H., R.L. Peiffer, C.L. Cullen, D.M. Heins. 2006.
Classification of feline intraocular neoplasms based on
morphology, histochemical staining, and
immunohistochemical labeling. Veterinary Ophthalmology. 9,
6:395-403.
• 4. F. Jelinek. 2003. Postinflammatory sarcoma in cats.
Experimental and Toxicologic Pathology. 55: 167-172.

Questions
• Relation to feline
post-vaccine
sarcomas?
• What about the
feline chronic
inflammatory
response is
oncogenic?


Slide 7

Feline post-traumatic ocular
sarcoma

Anya C. Hawthorn, MS, DVM*
D. Phillip Sponenberg, DVM, PhD

Acknowledgements
• Histology:
– Luther Vest
– Barbara Wheeler
– Jill Songer

• Sub-gross
photography
– Jerry Baber

Signalment and History
• 17 year old FS DSH
• Respiratory distress
• Mucopurulent nasal
discharge
• Missing upper canine
•“Lost” right eye 8 years ago
• Unresponsive to antibiotics

Gross Findings

PAS

Feline post-traumatic ocular
sarcoma
• associated with a past history of traumatic lens
rupture
• believed to arise from lens epithelium or ciliary body
• develop 1 to 10 years after the initial injury
• locally invasive, may metastasize, and carry a poor
prognosis
• Vimentin positive, cytokeratin negative, and
frequently produces PAS positive material similar to
lens capsule

References
• 1. Zeiss, CJ, E.M. Johnson. R.R. Dubiezig. 2003. Feline
Intraocular Tumors May Arise from Transformation of Lens
Epithelium. Veterinary Pathology. 40:355-362.
• 2. Meuten, D.J. 2002. Tumors in domestic Animals, 4th Ed.
Iowa State Press, Ames, Iowa.
• 3. Grahn, B.H., R.L. Peiffer, C.L. Cullen, D.M. Heins. 2006.
Classification of feline intraocular neoplasms based on
morphology, histochemical staining, and
immunohistochemical labeling. Veterinary Ophthalmology. 9,
6:395-403.
• 4. F. Jelinek. 2003. Postinflammatory sarcoma in cats.
Experimental and Toxicologic Pathology. 55: 167-172.

Questions
• Relation to feline
post-vaccine
sarcomas?
• What about the
feline chronic
inflammatory
response is
oncogenic?


Slide 8

Feline post-traumatic ocular
sarcoma

Anya C. Hawthorn, MS, DVM*
D. Phillip Sponenberg, DVM, PhD

Acknowledgements
• Histology:
– Luther Vest
– Barbara Wheeler
– Jill Songer

• Sub-gross
photography
– Jerry Baber

Signalment and History
• 17 year old FS DSH
• Respiratory distress
• Mucopurulent nasal
discharge
• Missing upper canine
•“Lost” right eye 8 years ago
• Unresponsive to antibiotics

Gross Findings

PAS

Feline post-traumatic ocular
sarcoma
• associated with a past history of traumatic lens
rupture
• believed to arise from lens epithelium or ciliary body
• develop 1 to 10 years after the initial injury
• locally invasive, may metastasize, and carry a poor
prognosis
• Vimentin positive, cytokeratin negative, and
frequently produces PAS positive material similar to
lens capsule

References
• 1. Zeiss, CJ, E.M. Johnson. R.R. Dubiezig. 2003. Feline
Intraocular Tumors May Arise from Transformation of Lens
Epithelium. Veterinary Pathology. 40:355-362.
• 2. Meuten, D.J. 2002. Tumors in domestic Animals, 4th Ed.
Iowa State Press, Ames, Iowa.
• 3. Grahn, B.H., R.L. Peiffer, C.L. Cullen, D.M. Heins. 2006.
Classification of feline intraocular neoplasms based on
morphology, histochemical staining, and
immunohistochemical labeling. Veterinary Ophthalmology. 9,
6:395-403.
• 4. F. Jelinek. 2003. Postinflammatory sarcoma in cats.
Experimental and Toxicologic Pathology. 55: 167-172.

Questions
• Relation to feline
post-vaccine
sarcomas?
• What about the
feline chronic
inflammatory
response is
oncogenic?


Slide 9

Feline post-traumatic ocular
sarcoma

Anya C. Hawthorn, MS, DVM*
D. Phillip Sponenberg, DVM, PhD

Acknowledgements
• Histology:
– Luther Vest
– Barbara Wheeler
– Jill Songer

• Sub-gross
photography
– Jerry Baber

Signalment and History
• 17 year old FS DSH
• Respiratory distress
• Mucopurulent nasal
discharge
• Missing upper canine
•“Lost” right eye 8 years ago
• Unresponsive to antibiotics

Gross Findings

PAS

Feline post-traumatic ocular
sarcoma
• associated with a past history of traumatic lens
rupture
• believed to arise from lens epithelium or ciliary body
• develop 1 to 10 years after the initial injury
• locally invasive, may metastasize, and carry a poor
prognosis
• Vimentin positive, cytokeratin negative, and
frequently produces PAS positive material similar to
lens capsule

References
• 1. Zeiss, CJ, E.M. Johnson. R.R. Dubiezig. 2003. Feline
Intraocular Tumors May Arise from Transformation of Lens
Epithelium. Veterinary Pathology. 40:355-362.
• 2. Meuten, D.J. 2002. Tumors in domestic Animals, 4th Ed.
Iowa State Press, Ames, Iowa.
• 3. Grahn, B.H., R.L. Peiffer, C.L. Cullen, D.M. Heins. 2006.
Classification of feline intraocular neoplasms based on
morphology, histochemical staining, and
immunohistochemical labeling. Veterinary Ophthalmology. 9,
6:395-403.
• 4. F. Jelinek. 2003. Postinflammatory sarcoma in cats.
Experimental and Toxicologic Pathology. 55: 167-172.

Questions
• Relation to feline
post-vaccine
sarcomas?
• What about the
feline chronic
inflammatory
response is
oncogenic?


Slide 10

Feline post-traumatic ocular
sarcoma

Anya C. Hawthorn, MS, DVM*
D. Phillip Sponenberg, DVM, PhD

Acknowledgements
• Histology:
– Luther Vest
– Barbara Wheeler
– Jill Songer

• Sub-gross
photography
– Jerry Baber

Signalment and History
• 17 year old FS DSH
• Respiratory distress
• Mucopurulent nasal
discharge
• Missing upper canine
•“Lost” right eye 8 years ago
• Unresponsive to antibiotics

Gross Findings

PAS

Feline post-traumatic ocular
sarcoma
• associated with a past history of traumatic lens
rupture
• believed to arise from lens epithelium or ciliary body
• develop 1 to 10 years after the initial injury
• locally invasive, may metastasize, and carry a poor
prognosis
• Vimentin positive, cytokeratin negative, and
frequently produces PAS positive material similar to
lens capsule

References
• 1. Zeiss, CJ, E.M. Johnson. R.R. Dubiezig. 2003. Feline
Intraocular Tumors May Arise from Transformation of Lens
Epithelium. Veterinary Pathology. 40:355-362.
• 2. Meuten, D.J. 2002. Tumors in domestic Animals, 4th Ed.
Iowa State Press, Ames, Iowa.
• 3. Grahn, B.H., R.L. Peiffer, C.L. Cullen, D.M. Heins. 2006.
Classification of feline intraocular neoplasms based on
morphology, histochemical staining, and
immunohistochemical labeling. Veterinary Ophthalmology. 9,
6:395-403.
• 4. F. Jelinek. 2003. Postinflammatory sarcoma in cats.
Experimental and Toxicologic Pathology. 55: 167-172.

Questions
• Relation to feline
post-vaccine
sarcomas?
• What about the
feline chronic
inflammatory
response is
oncogenic?


Slide 11

Feline post-traumatic ocular
sarcoma

Anya C. Hawthorn, MS, DVM*
D. Phillip Sponenberg, DVM, PhD

Acknowledgements
• Histology:
– Luther Vest
– Barbara Wheeler
– Jill Songer

• Sub-gross
photography
– Jerry Baber

Signalment and History
• 17 year old FS DSH
• Respiratory distress
• Mucopurulent nasal
discharge
• Missing upper canine
•“Lost” right eye 8 years ago
• Unresponsive to antibiotics

Gross Findings

PAS

Feline post-traumatic ocular
sarcoma
• associated with a past history of traumatic lens
rupture
• believed to arise from lens epithelium or ciliary body
• develop 1 to 10 years after the initial injury
• locally invasive, may metastasize, and carry a poor
prognosis
• Vimentin positive, cytokeratin negative, and
frequently produces PAS positive material similar to
lens capsule

References
• 1. Zeiss, CJ, E.M. Johnson. R.R. Dubiezig. 2003. Feline
Intraocular Tumors May Arise from Transformation of Lens
Epithelium. Veterinary Pathology. 40:355-362.
• 2. Meuten, D.J. 2002. Tumors in domestic Animals, 4th Ed.
Iowa State Press, Ames, Iowa.
• 3. Grahn, B.H., R.L. Peiffer, C.L. Cullen, D.M. Heins. 2006.
Classification of feline intraocular neoplasms based on
morphology, histochemical staining, and
immunohistochemical labeling. Veterinary Ophthalmology. 9,
6:395-403.
• 4. F. Jelinek. 2003. Postinflammatory sarcoma in cats.
Experimental and Toxicologic Pathology. 55: 167-172.

Questions
• Relation to feline
post-vaccine
sarcomas?
• What about the
feline chronic
inflammatory
response is
oncogenic?


Slide 12

Feline post-traumatic ocular
sarcoma

Anya C. Hawthorn, MS, DVM*
D. Phillip Sponenberg, DVM, PhD

Acknowledgements
• Histology:
– Luther Vest
– Barbara Wheeler
– Jill Songer

• Sub-gross
photography
– Jerry Baber

Signalment and History
• 17 year old FS DSH
• Respiratory distress
• Mucopurulent nasal
discharge
• Missing upper canine
•“Lost” right eye 8 years ago
• Unresponsive to antibiotics

Gross Findings

PAS

Feline post-traumatic ocular
sarcoma
• associated with a past history of traumatic lens
rupture
• believed to arise from lens epithelium or ciliary body
• develop 1 to 10 years after the initial injury
• locally invasive, may metastasize, and carry a poor
prognosis
• Vimentin positive, cytokeratin negative, and
frequently produces PAS positive material similar to
lens capsule

References
• 1. Zeiss, CJ, E.M. Johnson. R.R. Dubiezig. 2003. Feline
Intraocular Tumors May Arise from Transformation of Lens
Epithelium. Veterinary Pathology. 40:355-362.
• 2. Meuten, D.J. 2002. Tumors in domestic Animals, 4th Ed.
Iowa State Press, Ames, Iowa.
• 3. Grahn, B.H., R.L. Peiffer, C.L. Cullen, D.M. Heins. 2006.
Classification of feline intraocular neoplasms based on
morphology, histochemical staining, and
immunohistochemical labeling. Veterinary Ophthalmology. 9,
6:395-403.
• 4. F. Jelinek. 2003. Postinflammatory sarcoma in cats.
Experimental and Toxicologic Pathology. 55: 167-172.

Questions
• Relation to feline
post-vaccine
sarcomas?
• What about the
feline chronic
inflammatory
response is
oncogenic?


Slide 13

Feline post-traumatic ocular
sarcoma

Anya C. Hawthorn, MS, DVM*
D. Phillip Sponenberg, DVM, PhD

Acknowledgements
• Histology:
– Luther Vest
– Barbara Wheeler
– Jill Songer

• Sub-gross
photography
– Jerry Baber

Signalment and History
• 17 year old FS DSH
• Respiratory distress
• Mucopurulent nasal
discharge
• Missing upper canine
•“Lost” right eye 8 years ago
• Unresponsive to antibiotics

Gross Findings

PAS

Feline post-traumatic ocular
sarcoma
• associated with a past history of traumatic lens
rupture
• believed to arise from lens epithelium or ciliary body
• develop 1 to 10 years after the initial injury
• locally invasive, may metastasize, and carry a poor
prognosis
• Vimentin positive, cytokeratin negative, and
frequently produces PAS positive material similar to
lens capsule

References
• 1. Zeiss, CJ, E.M. Johnson. R.R. Dubiezig. 2003. Feline
Intraocular Tumors May Arise from Transformation of Lens
Epithelium. Veterinary Pathology. 40:355-362.
• 2. Meuten, D.J. 2002. Tumors in domestic Animals, 4th Ed.
Iowa State Press, Ames, Iowa.
• 3. Grahn, B.H., R.L. Peiffer, C.L. Cullen, D.M. Heins. 2006.
Classification of feline intraocular neoplasms based on
morphology, histochemical staining, and
immunohistochemical labeling. Veterinary Ophthalmology. 9,
6:395-403.
• 4. F. Jelinek. 2003. Postinflammatory sarcoma in cats.
Experimental and Toxicologic Pathology. 55: 167-172.

Questions
• Relation to feline
post-vaccine
sarcomas?
• What about the
feline chronic
inflammatory
response is
oncogenic?


Slide 14

Feline post-traumatic ocular
sarcoma

Anya C. Hawthorn, MS, DVM*
D. Phillip Sponenberg, DVM, PhD

Acknowledgements
• Histology:
– Luther Vest
– Barbara Wheeler
– Jill Songer

• Sub-gross
photography
– Jerry Baber

Signalment and History
• 17 year old FS DSH
• Respiratory distress
• Mucopurulent nasal
discharge
• Missing upper canine
•“Lost” right eye 8 years ago
• Unresponsive to antibiotics

Gross Findings

PAS

Feline post-traumatic ocular
sarcoma
• associated with a past history of traumatic lens
rupture
• believed to arise from lens epithelium or ciliary body
• develop 1 to 10 years after the initial injury
• locally invasive, may metastasize, and carry a poor
prognosis
• Vimentin positive, cytokeratin negative, and
frequently produces PAS positive material similar to
lens capsule

References
• 1. Zeiss, CJ, E.M. Johnson. R.R. Dubiezig. 2003. Feline
Intraocular Tumors May Arise from Transformation of Lens
Epithelium. Veterinary Pathology. 40:355-362.
• 2. Meuten, D.J. 2002. Tumors in domestic Animals, 4th Ed.
Iowa State Press, Ames, Iowa.
• 3. Grahn, B.H., R.L. Peiffer, C.L. Cullen, D.M. Heins. 2006.
Classification of feline intraocular neoplasms based on
morphology, histochemical staining, and
immunohistochemical labeling. Veterinary Ophthalmology. 9,
6:395-403.
• 4. F. Jelinek. 2003. Postinflammatory sarcoma in cats.
Experimental and Toxicologic Pathology. 55: 167-172.

Questions
• Relation to feline
post-vaccine
sarcomas?
• What about the
feline chronic
inflammatory
response is
oncogenic?


Slide 15

Feline post-traumatic ocular
sarcoma

Anya C. Hawthorn, MS, DVM*
D. Phillip Sponenberg, DVM, PhD

Acknowledgements
• Histology:
– Luther Vest
– Barbara Wheeler
– Jill Songer

• Sub-gross
photography
– Jerry Baber

Signalment and History
• 17 year old FS DSH
• Respiratory distress
• Mucopurulent nasal
discharge
• Missing upper canine
•“Lost” right eye 8 years ago
• Unresponsive to antibiotics

Gross Findings

PAS

Feline post-traumatic ocular
sarcoma
• associated with a past history of traumatic lens
rupture
• believed to arise from lens epithelium or ciliary body
• develop 1 to 10 years after the initial injury
• locally invasive, may metastasize, and carry a poor
prognosis
• Vimentin positive, cytokeratin negative, and
frequently produces PAS positive material similar to
lens capsule

References
• 1. Zeiss, CJ, E.M. Johnson. R.R. Dubiezig. 2003. Feline
Intraocular Tumors May Arise from Transformation of Lens
Epithelium. Veterinary Pathology. 40:355-362.
• 2. Meuten, D.J. 2002. Tumors in domestic Animals, 4th Ed.
Iowa State Press, Ames, Iowa.
• 3. Grahn, B.H., R.L. Peiffer, C.L. Cullen, D.M. Heins. 2006.
Classification of feline intraocular neoplasms based on
morphology, histochemical staining, and
immunohistochemical labeling. Veterinary Ophthalmology. 9,
6:395-403.
• 4. F. Jelinek. 2003. Postinflammatory sarcoma in cats.
Experimental and Toxicologic Pathology. 55: 167-172.

Questions
• Relation to feline
post-vaccine
sarcomas?
• What about the
feline chronic
inflammatory
response is
oncogenic?