Transcript How to decelerate aging - Frontiers in Bioscience

Aging & Healthy living
Siamak Tabibzadeh MD
Professor,
Department of Oncologic Radiology
University of California,
Irvine, California
Laguna Beach Rotary Club,
31106 South Coast Highway,
Laguna Beach, California 92651
July 13, 2012
President,
Frontiers in Bioscience Research
Institute in Aging and Cancer
Irvine, California
Formation of our universe
First there was nothing
Big bang
History of our universe
Formation of atoms
Cooling
Formation of H
Major atoms that form life
H: Hydrogen
C: Carbon
O: Oxygen
N: Nitrogen
Formation of milky way galaxy
Formation of milky way galaxy
Collapsing under gravity
Formation of sun
Formation of earth
Comets bring water to earth
Formation of life on earth
Time (Billions of years)
Single cell forms
Oxygen
accumulates
Fossilized life
forms
First
photosynthesis
Life formed
Earth formed
Formation of protocell
Formation of protocell
Protocell
Protocells are simple yet are immortal
Infinite cycles of cell growth and division
Blissful matrimony leads to evolution
Parasitism at the heart of boosting cell energy and mortality
Blissful matrimony leads to evolution
Generation of energy
Movement a direct result of evolution
Structure of flagellum
Cell with flagellum
Evolution of flagellum
Cell with flagellum
Sperm
Divergent species form by evolution
Time (Millions of years)
First hominids
First primates
First flowering plants
and insects
First mammals
Permian extinction
First amphibians
First land plants and
animals
First fish
Cambian explosion of
life begins
First intervertabrates
Darwin uncovers evolution
Darwin’s handwritten note
Tree of life
Evolution is seen in blueprint of life
Tree of life
Tree of life
The dark side of generation of energy
Generation of toxic by-products
Aging
Monocellular organisms are immortal
Amoeba
Some cells in humans are immortal
Stem cells
Cancer cells
Causes of aging
Stem cell basis of aging
Damage to stem cells
Causes of aging
Inflammatory basis of aging
Inflamm-aging
Causes of aging
Inflammatory basis of aging
Reduce inflammation by aspirin
Willow bark
Acetylesalicyclic acid
How to decelerate aging
Avoid stress
How to decelerate aging
Avoid fatty food
and
of oil
Avoid
Avoid
Avoid
salt
redconsumption
sugar
meat
Avoid alcohol
and
cigarette
Glucose
How to decelerate aging
Exercise daily
How to decelerate aging
5 Minute sun * 1000 IU Vitamin D daily
How to decelerate aging
Consume 10 cups of water per day
How to decelerate aging
Have a balanced diet
Restrict calorie
Have multiple meals
Avoid obesity
How to decelerate aging
Consume legumes and nuts
How to decelerate aging
Consume sour or un-ripened fruits
Tamarind
Avoid sweet fruits
How to decelerate aging
Consume vegetables
Capsaicin
How to decelerate aging
Consume glass of wine with resveratrol
How to decelerate aging
Consume vegetables
Wasabe
Cauliflower
Arugula
Horseradish
Broccoli
Garlic
Rhubarb
Wasabe
How to decelerate aging
General
1. Reduce calorie intake. Reduction of calorie intake per day has been
shown in many species to increase longevity
2. Have multiple meals (~6-10) per day comprised of smaller portions to
avoid fluctuation of insulin. Insulin inhibits gene signaling that improve
repair.
3. Do not allow yourself to get fat. Increase body mass increases the work
of stem cells
4. Have a balanced diet comprised of fibers, minerals, vitamins, and protein
5. Reduce stress in your life. Stress shorten lifespan
7. Smile frequently. Smiling reduces stress
8. Rest and have regular sleep that allows you to have a fresh feeling the
next day
9. Take vacations and relax with music, good conversation, or a hobby
each day
10. Choose a job that you love to reduce your stress during the day
11. If possible do not commute to reduce stress due to driving
12. Exercise frequently (short periods of 2-3 times daily and one to two
times per week of exercise that increases the heart rate). Exercise,
increases blood flow, and increases the endorphins in the brain allowing
you to become happy and relaxed
How to decelerate aging
Foods the avoid
1.Sugar. Glucose turns on insulin pathway and inhibits the repair pathways.
Glucose whether in natural (honey, grapes, raisin) or artificial (sugar, or
sugar cubes) products exert the same effects
2.Fat. All food that you eat has fat. Do not add fat to your food (do not fry,
do not add cheese)
3.Salt. Excess salt leads to vasoconstriction and over time leads to
hypertension. Use seasoning, lemon juice or pepper to add taste to your
food
4.Red meat. Myoglobin which gives red color to red meat has an iron core.
Iron causes cell damage.
5.Animal meat. Animal meats particularly when barbecued lead to aging
and cancer
6.Avoid sweet fruits
How to decelerate aging
Foods to consume
1.Have 3-6 cups of water (warm) in the morning. This increases the loss of
waste products from your body and dilutes them in the blood
2.Try to use 10 cups of water per day
3.Get sunlight of about 5 minutes per day to receive the required vitamin D.
Have your vitamin D measured in your blood and if low, add 1000 to 2000
IU of vitamin D to your diet
4.Include yogurt in your diet
5.Use proteins of plant origin (lentil, bean, pea, tofu)
6.Include legumes in your diet (almond, hazel nut)
7.Include unripened or sour fruits in your diet
8.Include turmeric in your die. Turmeric is anti-oxidant and reduces
damage to cells which results from food consumption
9.Include vegetables in your diet. Vegetables add fiber, vitamins and
minerals to your diet.
10.Include hot peppers in your diet. The capsaicin in hot peppers is antiinflammatory and also cause euphoria
11.Include Wasabi, Horseradish, Rhubarb, Cauliflower in your diet
12.Take two cloves of crushed garlic and one tablespoonful of ultra virgin
olive oil with one to two tablespoonful of yogurt (mix together) with your
lunch and your dinner
How to decelerate aging
Medicine
1.Resveratrol is anti-oxidant and has been shown to increase longevity in
many different species. Glucoronides in the red wine increase the
absorption of resveratrol significantly from the gastrointestinal tract. The
dose for humans has not been determined but approximate dose is at least
25-500 mg.
2. Aspirin is anti-inflammatory (>1000 mg daily) and has been shown to
reverse (at 3-4 grams per day) the diabetic hyperglycemia and to lower
cholesterol in the blood. To avoid gastrointestinal impact of the acidic
nature of this drug, aspirin might be used as salsalate.
3. Vitamin D; 1000-2000 IU units per day
Acknowledgement
Chris Wiley, PhD
Chris Rollins, MS
Casey Raasumaa, MS
Research Scientist
Research Associate
Research Associate
Chris does cutting edge research
on aging. His work shows
pathways that lead to generation
of senescent cells that contribute
to overall aging
Chris is investigating the
hypothesis that cancer cells are
generated by massive cell
damage
Casey investigating new pathways
that lead to increase in healthspan
and lifespan. She also provides
administrative background to make
FBS a cutting-edge research center
Daniel Tabibzadeh, BS
Development Manager
Daniel creates and maintains the
Frontiers in Bioscience Journal
and Research Institute WebSites
www.frontbiosci.org
www.frontbiosci.org/ri