Transcript Applied Analytics Microspec IR

Combining
Analytical Sensors
and NeSSI to
Improve PAT
Brian Marquardt and Dave Veltkamp
Applied Physics Laboratory
Center for Process Analytical Chemistry
University of Washington
Seattle, WA 98105
What is NeSSI™?
Industry-driven effort to
define and promote a new
standardized alternative to
sample conditioning systems
for analyzers and sensors
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Standard fluidic interface for
modular surface-mount
components
Standard wiring and
communications interfaces
Standard platform for
micro analytics
What does NeSSI™ Provide
Simple “Lego-like” assembly
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Easy to re-configure
No special tools or skills required
Standardized flow components
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“Mix-and-match” compatibility between vendors
Growing list of components
Standardized electrical and communication (Gen II)
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“Plug-and-play” integration of multiple devices
Simplified interface for programmatic I/O and control
Advanced analytics (Gen III)
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Micro-analyzers
Integrated analysis or “smart” systems
Where Does NeSSI™ Fit in the Lab
Instrument/Sensor Interfaces
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Design standards make development simpler
Reduced toolset to be mastered
Reduced sample variability to account for
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Calibration/validation built-in
Consistent physical environment for measurement
Stream switching and/or mixing allow generation of
standards to match analytical requirements
Reaction monitoring
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Microreactors and continuous flow reactors
Batch reactors (with fast loop)
Sample Preparation
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Gas handling (mixing, generation, delivery)
Liquid handling (mixing, dilution, conditioning, etc.)
The NeSSI Could Become the Base for
a Micro-Analytical Lab
‘A DEVELOPMENT PLATFORM’
NeSSI with an Array of MicroAnalytical Techniques will Impact
Many Industries
Process Control
Process
Optimization
Product
Development
Sensing Technologies
Gas Chromatography
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Thermal Desorption (?)
Dielectric (√)
Spectroscopies
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IR (+), NIR (+)
UV- Vis (+)
Raman (√)
Fluorescence (+)
Impedance (+)
Conductivity (√)
Refractive Index (√)
Vapochromic Sensors (+)
GLRS (+)
Particle Sizing
 Light scattering (?)
Turbidity (+)
pH (√)
RGA (+)
Mass Spectrometry (√)
LC, SEC, IC (+)
Terrahertz (?)
NeSSI™: Enabler for MicroAnalytical
Standard
“connectivity
(the “rail” concept)
”
Standard Electrical (Digital) Interface “Rail”
V
Anyone’s Sensor
P
Anyone’s Actuator
SAM*
Standard
“hockey-puckPC”
Standard Mechanical Interface “Rail”
*Sensor/Actuator Manager
What technologies are available
Suitability for modular sampling systems
Phased Micro Gas Analyzer
PHASED microGC
Other Analytical:
Ion, Nox. O2, pH
Conductivity,
NOx, Turbidity,
Density, Opacity
Refractive Index,
Others
Network
Network
D/A
A/D
Mod
Valve
Press/
Temp
Substrate
Substrate
On/Off and
Modulating valves
Flow Sensor w/
Temp, Pressure
w/ Temp
Chemometric
Sensors for
Complex Analytical
Measurements.
Substrate
PHASED *
Micro GC
Moisture in
Dry Gases
*PHASED: Courtesy of Honeywell
MICRO-GC
GCM 5000
< 20 W Power
3 x 2 x 0.6 inches
100 gm / 3 oz.
www.slsmt.com
SLS
ABB Natural Gas Chromatograph
Dimensions: 6.75“ dia. × 16'' long × 9.00'' tall
Weight: Approximately 28 lb. (12.7 Kg)
Analysis section contains stream
selection solenoids, pressure regulation,
32 bit digital detector electronics and a
dual-train chromatograph in a single,
replaceable module (coffee-cup sized)
Siemens microSAM GC
Valveless live injection with
software-adjustable injection
volume
Maintenance-free column
switching and electronic
pressure control
Accurate measuring results by
multiple parallel microdetectors
Can be mounted directly at the
sample extraction point
because only a single auxiliary
gas and very little electrical
power is required
Simple remote control with
Windows-based software and
Ethernet communication
Agilent 3000 Micro GC
Custom configurations with 1 to 4
replaceable chromatographic
channels. Choose from various micromachined injectors, columns, sample
conditioners, and application-specific
reports.
The modular GC design maximizes
uptime, with repair as simple as
exchanging one module for another.
Increase sensitivity, maintain high
precision, remove unwanted
contaminants from your sample, or
speed up analysis with variable, fixed
or backflush injection options.
Digital pneumatics control carrier gas
flow electronically, enhancing
reliability and precision while further
simplifying operation.
Dimensions: 5.9” x 9.8” x 16.1”
Wt: 18 – 37 lbs (portable)
Applied Analytics Inc. Diode Array
OMA-300
A Fiber-optics-diodearray process analyzer
For on-line concentration
monitoring
Applied Analytics Microspec IR
FEATURES
Ideal for monitoring PPM level
WATER in various solvents
In stream quantitative measurements
Contains no moving parts and
Extremely robust allowing for
installations in process stream
environments
Replaces analyzers such as process
spectrometers in the process plant.
NeSSI IR Gas Cell
Sentelligence Current NIR Sensors
Removable Tip
Version
- NIR Sensors
IR Microsystems Microarray 64
Board
Dimensions:
66
x
53
mm
2
Wilks Enterprise
InfraSpec Variable Filter Array
Agilent NeSSI Dielectric Sensor
Cable to
Agilent
Network
Analyzer
Dielectric
Probe
Close up
of
Coaxial
Probe
Tip
Inner
Body
O-ring
(inside)
Swagelok
2-Port
Valve Base
Outer
Body
Exploded
View
Liquid Chromatography for NeSSI™
Scott Gilbert, CPAC Visiting Scholar
Crystal Vision Microsystems LLC
Atofluidic Technologies, LLC
Split flow approach to sampling
Liters per minute
sample in
diluent in
microliters
per minute
micromixer
nanoliters
per minute
m-fluidic LC Chip for On-line
Sample Pretreatment
Pulsed electrochemical
detection (on-chip)
column
mobile phase in
Aspectrics EP-IR with Gas Cell
15”
7”
Spectrometer
5.2”
Gas cell
Glow source
Interfacing NeSSI™ to ASI microFast GC™
GC sipper port
EP-IR gas cell
Vapochromic sensor optical cell
Complete gas/vapor sensing test platform on the bench top
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Gas delivery, vapor generation, and blending in NeSSI™
Real time verification of composition using GC and EP-IR
Easily extended to include other analytical and sample treatments
NeSSI System for Gas/Vapor
Generation and Sensor Calib.
CPAC Funded Technology
Developments
Development of a Micro-NMR System
M. McCarthy, UC Davis
NMR spectrum of a 3 micro liter
water sample using a RF micro-coil
Spreeta SPR sensing components
SPIRIT system performs SPR
detection using Texas
Instruments’ Spreeta SPR
chips
Chips are mass-produced by
TI, cost ~$4 in large quantities
Each chip can perform three
simultaneous measurements
Systems contain 8 chips, for
24 total sensing channels
Each Spreeta chip contains
all of the optical
components needed for
sensitive SPR measurement
of biomolecular interactions
Clem Furlong, et al, UW
Fringing Field Dielectric NeSSI Sensor
Alex Mamishev EE and Marquardt CPAC, UW
Raman/NIR/UV-Vis Sensor Module
NeSSI Raman Sampling Block
• Reactor NeSSI substrate
• Sample conditioning to induce backpressure to
reduce bubble formation and the heated
substrate allows analysis at reactor conditions
PtO2 NeSSI Sensor
Fiber optic
cable to
Ocean Optics
Spectrometer
Fiberoptic
Probe(405
nm LED)
Inner
Body
O-ring
(inside)
Swagelok
2-Port
Valve Base
Close up
of Outer
Body Tip
Outer
Body
VapochromicT
ip
Exploded
View
Calibrated Gas Generation
Application of Permeation Apparatus
Acknowledgments
Center for Process Analytical Chemistry
Students – Charles Branham and Wes
Thompson, UW
Professor Kent Mann, Univ. of Minnesota
Clem Furlong – UW Medical Genetics
Mike McCarthy and group – UC Davis
Scott Gilbert – UW Visiting scholar
Swagelok, Parker and Circor
ABB, Agilent, Aspectrics, Honeywell,
ExxonMobil