Transcript Н - Lab1

-Peptid:oxytocin
CYS-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly
Í----------S-S--------------Í
C-Y-I-Q-N-C-P-L-G
Í-------S-S---Í
OPIOIDER
Peptider som har opiums virkning.
Binder seg til opiums reseptorer
Sokolov O. et al.(2014)Peptides 56:6871
Opioider fra casein (ostestoff)
ß-casomorfin 1-3;1-4;1-5;1-7 og 1-8
Tyr-Pro-Phe-Pro-Gly-Pro-Ile-Pro
Y-P-F-P-G-P-I-P
Fra Alpha-casein
RYLGYL
Arg-Tyr-Leu-Gly-Tyr-Leu
Fra menneske casein
Tyr-Pro-Phe-Val-Glu-Pro-Ile
Y-P-F-V-E-P-I
Post Partum Psykose
Fra Gliadin
Gliadinomorfin: Y-P-Q-P-Q-P-F
Tyr-Pro-Gln-Pro-Gln-Pro-Phe
Fra Glutenin.
A5 glumorfin=G-Y-Y-P-T
A4 Glumorfin=G-Y-Y-P
Fra glutenin
Glumorfin B5:Y-G-G-W-L
Glumorfin B4:Y-G-G-W
Glumorfin C: Y-P-I-S-L
Andre opioder fra melk
Alpha-Lactorphin: Y-G-L-F (amid)
Beta-lactorphin :Y-L-L-F (amid)
Casorphin:Y-P-S-F (amid)
Table 2, Effects of exorphins
on brain
symptom
Mekanisme
Hyper motoric
Analgesia
Social indifference
Hyperdopaminergic
Opioid receptors
Opioid receptosr
Hyperarousal
Poor habituation
Stress like state
Opioid>dopamine
Increase in dopamine
,decrease in serotonin
Interferes with cell
growth/apoptosis
Cortisone increase
Nerve cell activtin
Hallucinations
Visual and auditive
Fos antigen increase
Fos antigen increase in
Geniculate nuclei
Trophic CNS effects
referense
Test/kommentar
Open Field
Tail flick test
Seperation distress call
abrogation
Galvanic skin test
Galvanic skin test
NMR
Dexamethasone
suppression test
ELISA on brain nuclei
ELISA
Table 3. Peripheral effects
sympto
m
mechanism
Test/comment
Insulin
release
Enterocyte
growth
Inhibit.
Obstipation
Pancreas
receptors
In vivo and
vitro
Microscopy
& Thymdin
Incorpration
Mimicking
Metenkephalin
Clinical
Observ.