Transcript Slide 1

CReST
Program
Update
The Story…
“One in a billion” – genomic medicine discovers the
cause of a young boy’s disease
• Howard Jacobs, PhD
Human Molecular Genetics Center,
Medical College of Wisconsin
• X-linked Inhibitor of Apoptosis (XIAP)
• Cysteine-aspartic acid proteases (caspases)
• XIAP and initiator caspase 9
 biochemistry: structure and protein interactions
 genetics: effect of mutations in XIAP
How students approach the story…
Fall semester: integrated into two courses
• Biochemistry (Heather Mernitz)
 Previous CReST student introduced XIAP/caspase
 Model system for core concepts
 Capstone project: Student teams investigated one of
three pathways in detail
• Genetics (Carl Ball)
 Genomics of “One in a Billion”
 Capstone project: One student team investigated an
genetic disorder in XIAP gene
• Capstone: Public joint poster session
How students approach the story…
Spring semester: independent study
• Tina Jesulin, Sara Klosiewski, Phaya Lem, Jessica Weiss
Build on foundation from course work
• Goal: model illustrating XIAP function
 Biochemical principles
 Genetic variants
• Research XIAP literature
• Selected problem – see their poster