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ABSTRACT Suicide is a major public health problem in the United States. Despite research indicating high rates of depression in autism spectrum disorders (ASD), little is known about suicidality in this population. A systematic literature review was conducted to provide a more thorough understanding of suicidality in ASD from childhood through adulthood. The purpose of the review was to provide information about the current state of evidence on the topic, and to identify key areas for future research. Results indicated that the evidence base is small, but that individuals with ASD are at a higher risk for suicidality than those without ASD and suicidal ideation is more common in individuals with ASD than are suicide attempts. Adolescents and young adults are at greatest risk for suicidality in comparison to children and older adults, and high functioning individuals with ASD are at a higher risk for suicidality than lower functioning individuals. Finally, bullying and relationship difficulties were significant triggers for both suicidal ideation and suicide attempts in some studies. INTRODUCTION Individuals with autism spectrum disorder (ASD) have impairments in social communication/interactions and repetitive/restricted behavior. However, co-occurring cognitive and psychiatric difficulties are also common. Many of these co-occurring problems are specific risk factors for suicidality in the general population. These include: •Depression •Executive functioning & problem-solving difficulties •Impulsivity •Behavioral problems/aggression •Mood dysregulation Thus, individuals with ASD may be at particular risk for suicidal ideation (SI) and suicide attempts (SA). METHOD A systematic review of the literature was conducted using pre-defined search procedures and inclusion/exclusion criteria. Only 20 studies met inclusion criteria, and only 5 studies specifically addressed ASD and suicide. Based on available evidence, some preliminary findings emerged. ASD and Suicidality Across the Lifespan Valerie M. Vorderstrasse, PsyD & Micah O. Mazurek, PhD University of Missouri CONCLUSIONS RESULTS Studies Addressing Suicidality in Individuals with ASD Author (year) Kato et al. (2012) Mayes et al. (2013) Ages Prevalence Associated Factors 21-45 Sample (n=587) •7% had ASD Hospitalized for SA Method: Chart review •Male •Early adulthood •Living alone •Impulsivity •Relationship difficulties 1-16 Method Sample ASD (n=791) TD (n=186) Depression (n=35) Method: Parent report Mikami et al. 14-19 Sample (n=94) (2009) Hospitalized for SA Method: Chart review Raja et al. (2011) 21-39 Sample (n=26) Psychiatric patients with ASD Method: Chart review Shtayermann 16-22 Sample (n=10) (2007) Youth with ASD Method: Self-report questionnaires •14% of ASD Group had SI/SA •0.5% of TD Group had SI/SA •Adolescence •Behavioral problems •Mood dysregulation •Relationship difficulties •Bullying •12.8% had ASD •Male •Lack of social support •Restricted thinking •Relationship difficulties •Bullying •31% had SI •3.8% had SA •7.6% suicide •Male •Early adulthood •Psychosis •Isolation •Social failures •50% had SI •Higher IQ •Early adulthood •Depression •Bullying Summary of findings: • Individuals with ASD are at risk for suicidality. • Suicidal ideation is more common than suicide attempts. • Adolescents and young adults are at greatest risk for suicidality • High functioning individuals with ASD are at a higher risk for suicidality than lower functioning individuals. • Bullying and relationship difficulties are significant triggers for suicidal ideation and attempts. Implications for practice: There is a clear need for: • Regular screening for suicidality in individuals with ASD • Bullying prevention efforts • Preparing youth with ASD for life transitions Future Research: • Large-scale longitudinal studies are needed to further examine prevalence and predictors of suicidality in individuals with ASD • More research is needed to better understand how to assess, prevent, and treat suicidality in ASD. • ASD-specific measures are needed to assess suicidality SELECTED REFERENCES Kato, K., Katsunaka, M., Akama, F., Yamada, K., Maehara, M., Kimoto, K. et al. (2012). Clinical features of suicide attempts in adults with autism spectrum disorders. General Hospital Psychiatry, 1-4. Mayes, S. D., Gorman, A. A., Hillwig-Garcia, J., & Syed, E. (2013). Suicide ideation and attempts in children with autism. Research in Autism Spectrum Disorders, 7, 109-119. Mikami, K., Inomata, S., Hayakawa, N., Ohnishi, Y., Enseki, Y., Akitoshi, O. et al. (2009). Frequency and clinical features of pervasive developmental disorder in adolescent suicide attempts. General Hospital Psychiatry, 31, 163-166. Raja, M., Azzoni, A., & Frustaci, A. (2011). AUTISM spectrum disorders and suicidality. Clinical Practice and Epidemiology in Mental Health, 7, 97-105. Shtayermman, O. (2007). Peer victimization in adolescents and young adults diagnosed with Asperger’s syndrome: A link to depressive symptomatology, anxiety symptomatology, and suicidal ideation. Issues in Comprehensive Pediatric Nursing, 30, 87-107.