Transcript Hemodynamic disorders p.1 - Patho

Immunopathology
SYLLABUS:
RBP(Robbins Basic Pathology) Chapter:
Diseases of immunity
Immunopathology
179
Polyarteritis nodosa
108a
Glomerulonephritis
115
Rheumatic myocarditis
209
Hashimoto thyroidits
Polyarteritis nodosa
-early phase: degeneration of arterial wall with
fibrin deposition and partial or complete
destruction of external and internal elastic laminae
- inflammatory infiltration within and around
vessels predominantly composed of PMNs with
leukocytoclasia (fragmentation of their nuclei)
- intermediate phase: intimal proliferation,
thrombosis, and chronic inflammation in vessels
and perivascular tissue
- healed phase: fibrosis and recanalization
Polyarteritis nodosa
Polyarteritis nodosa
Glomerulonephritis
Possible lesions:
- diffusely enlarged hypercellular glomeruli
- mesangial cell proliferation
- infiltrating leukocytes
- lobular accentuation
- thickening of glomerular capillary wall
Glomerulonephritis
Glomerulonephritis
Rheumatic myocarditis
Aschoff bodies:
- foci of swollen eosinophilic collagen
- surrounded by lymphocytes (primarily T cells),
occasional plasma cells, and Anitschkow cells
(pathognomonic for RM plump macrophages with
abundant cytoplasm and central round-to-ovoid
nuclei with the chromatin disposed in a central,
slender, wavy ribbon ("caterpillar cells")
- larger macrophages become multinucleated to
form Aschoff giant cells
Rheumatic myocarditis
Rheumatic myocarditis
Hashimoto thyroidits
- lymphocytic infiltration of parenchyma with
follicles and prominent germinal centers
- plasma cells, histiocytes, and scattered
multinucleated giant cells may be present
- small, atrophic follicles with widespread Hürthle
cell change (epithelial cells distinguished by the
presence of abundant eosinophilic, granular
cytoplasm)
- in about 12% of case extensive fibrosis
(fibrous variant)
Hashimoto thyroidits
Hashimoto thyroidits