Transcript Slide 1
Clinical Trial Software
Medical Imaging Resource Center
John Perry
RSNA 2010 MIRC Courses
MIRC Overview
RSNA Clinical Trial and Research Software
Hands On: Using the RSNA Teaching File
Clinical Trial Dataflow
DICOM
HTTP
X
Database
Internet
HTTP / HTTPS
DICOM
X
DICOM
X
Data Acquisition
Sites
Principal Investigator
Site
CTP
Stand-alone application for clinical trials data:
Processing and communication
Simple installation and configuration:
Single-click installation
Single XML configuration file
Configurable for:
Data acquisition sites
Principal investigator sites
Platform-independent
CTP Admin Web Server
Administrative functions
Account management
Status display
Configuration display
System properties display
Script editors
Authentication
CTP Data Objects
DicomObject
Images
SR / KOS / GSPS objects
XmlObject
Text data
Flexible schema for identifiers
ZipObject
Encapsulation of trial-specific files
Embedded manifest to carry the identifiers
CTP Processing Pipelines
A pipeline is an ordered sequence of stages
A stage is an element to perform a function:
ImportService
Processor
StorageService
ExportService
Pipelines can have as many stages as necessary
CTP supports multiple pipelines
Standard ImportServices
DicomImportService
HttpImportService
PollingHttpImportService
DirectoryImportService
ArchiveImportService
- DICOM Storage SCP
- HTTP and HTTPS
- HTTP for firewall penetration
- manual submission
- bulk import
Standard Processors
DicomFilter
XmlFilter
ZipFilter
DicomDecompressor
DicomPixelAnonymizer
DicomAnonymizer
XmlAnonymizer
ZipAnonymizer
- triage for DicomObjects
- triage for XmlObjects
- triage for ZipObjects
- convert DICOM images
- blank pixel regions
- de-identify DicomObjects
- de-identify XmlObjects
- de-identify ZipObject manifests
Standard Processors
ObjectLogger
MemoryMonitor
IDMap
ObjectTracker
DatabaseVerifier
- performance measurement
- operation monitoring
- PHI ID lookup
- data acquisition management
- transfer confirmation between sites
Standard StorageServices
FileStorageService
Indexed file management
Web access with authentication
BasicFileStorageService
Indexed file management for the National Cancer
Institute NBIA system
Standard ExportServices
DicomExportService
HttpExportService
PolledHttpExportService
FtpExportService
DatabaseExportService
- DICOM Storage SCU
- HTTP and HTTPS
- HTTP for firewall penetration
- FTP
- external database interface
FileStorageService
Configurable tree structure
Build-in web server
Authentication
Browse patients / studies / data objects
Display images (tile / stack / series)
Export data objects of all types
Programmatic access via Ajax servlet
FileStorageService Viewer
DatabaseExportService
Integrated queue management
DatabaseAdapter
Interface between the DatabaseExportService and the
database itself
Must be developed for each unique database schema
Standard class to extend for a specific application
The HIPAA 18 (1-3)
1. Name
2. Location; all geographic subdivisions smaller than a
state, including street address, city, county, precinct,
zip code, and their equivalent geocodes.
3. Dates (all dates related to the subject of the
information, e.g. birth dates, admission dates,
discharge dates, encounter dates, surgery dates, etc.)
The HIPAA 18 (4-9)
4.
5.
6.
7.
8.
9.
Telephone numbers
Fax numbers
Electronic mail addresses
Social security numbers
Medical record numbers
Health plan beneficiary numbers
The HIPAA 18 (10-15)
10. Account numbers
11. Certificate / license numbers
12. Vehicle identifiers and serial numbers,
including license plate numbers
13. Device identifiers and serial numbers
14. Web Uniform Resource Locators (URLs)
15. Internet Protocol (IP) address numbers
The HIPAA 18 (16-18)
16. Biometric identifiers, including finger and voice
prints
17. Full face photographic images and any
comparable images
18. Any other unique identifying number,
characteristic, or code
De-indentification
Unnecessary PHI
Removal
Replacement with values that are the same for all
patients
Necessary PHI
Replacement with values that allow subjects, studies,
and images to be related to one-another, but that do
not allow identification of the human being
DICOM Supplement 142
Published in 2009
Defines de-identification profiles
Basic Profile: most aggressive
Several options for relaxing certain IDs
This is a major contribution: it provides expert
guidance for the de-identification of complex
datasets
CTP DicomAnonymizer
Fully scriptable de-identification instructions
DICOM Anonymizer Configurator
Web UI for creating and editing scripts
Support for DICOM Supplement 142 profiles
Profile scripts written by Justin Kirby at NCI
Support for user-defined profiles
Default script: 142 Basic
CTP Example
Data Acquisition Site
Modality
PACS
CTP
DicomImportService
DicomAnonymizer
HttpExportService
…
Principal Investigator Site
CTP
External Database
HttpImportService
FileStorageService
DatabaseExportService
DicomExportService
Local Disk
Workstation
Firewall Penetration
Principal Investigator Site
Internet
HTTP / HTTPS
DMZ
CTP
HttpImportService
PolledHttpExportService
DMZ
Secure Network
CTP
PollingHttpImportService
… (additional stages)
Adapting CTP
Flexible
All standard stages are highly configurable
Extensible
Integrated class loader
Interface-based structure
Abstract classes for easy development of new stages
Base class for developing database interfaces
CTP
Runs on Windows, Mac, Linux, Solaris
Requires only Java
Java and CTP are free
MIRC/CTP Users Meeting:
Monday, 12/29, from 3:00-4:15 in N127
Questions/Answers & Help
The MIRC Wiki
http://mircwiki.rsna.org
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http:forums.rsna.org
User Comments, Questions, & Answers
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