Transcript Slide 1

Peak Scientific Instruments Ltd
HOW DO I CHOOSE THE RIGHT GAS MANAGEMENT SYSTEM?
• What are the possible sources of gas?
• Who has experience about Gas Management Systems and can advise
me?
• What information do I need about LC/MS Gas requirements and where
will I find it?
• What are the decisions I need to make?
• Which one will be best for my lab / my LCMS system(s)?
• Are there any other considerations I should think about?
• Who will install the gas management system?
• What if I have problems and it stops working?
• How much will it cost to run?
Peak Scientific Instruments Ltd
WHAT ARE THE POSSIBLE SOURCES OF GAS?
•
In house gas already available
•
Liquid Nitrogen Dewar
•
Cylinder gas
•
Industrial gas generator
•
Laboratory gas generator
.
Peak Scientific Instruments Ltd
WHO HAS EXPERIENCE ABOUT GAS MANAGEMENT SYSTEMS
AND CAN ADVISE ME?
• Colleague with LC/MS experience
• Company preference already in place
• LC/MS user group
• Local guru or expert in country
• Personal knowledge/experience
• Technical publications
• Internet - Google
• LC/MS supplier
• Gas management system supplier.
Peak Scientific Instruments Ltd
SUMMARY OF GAS SOURCES AND INFORMATION
ALTERNATIVES
RECOMMENDATIONS
IN HOUSE GAS
DEWAR
CYLINDER
LABORATORY GAS GENERATOR
INDUSTRIAL GAS GENERATOR
COLLEAGUE
COMPANY PREFERENCE
LC/MS USER GROUP
LOCAL GURU OR EXPERT
PERSONAL KNOWLEDGE
END USER CHOICES
LCMS
MANUFACTURER
Peak Scientific Instruments Ltd
WHAT INFORMATION DO I NEED ABOUT LC/MS
GAS REQUIREMENTS AND WHERE WILL I FIND IT?
•
Consult the LCMS manufacturer/gas supplier
•
Confirm the gas requirements (nitrogen, air, other?)
•
Confirm the required specifications for flow and pressure
•
Are there any other special gas requirements?
•
Consult the LCMS site prep guide if available
•
Is there a defined level of noise acceptable in the laboratory
NOW YOU HAVE A GOOD IDEA OF WHAT YOU REQUIRE
.
Peak Scientific Instruments Ltd
WHICH GAS MANAGEMENT SYSTEM WILL BE BEST FOR MY LAB
AND MY LCMS SYSTEMS?
•
In house gas
•
Liquid Nitrogen Dewar
•
Cylinder gas
•
Industrial gas generator
•
Laboratory gas generator
SO HOW DO I DECIDE WHICH ONE?
Peak Scientific Instruments Ltd
WHAT ARE THE DECISIONS I NEED TO MAKE?
“What is right for the application and your lab?”
•
Stand alone gas generator for each LCMS in lab (using existing house air)?
•
Stand alone gas generator with separate external air compressor?
•
Laboratory gas generator with built in compressors for each LCMS ?
•
How many LCMS systems will require gas?
•
Is this likely to change (increase) in the near future?
•
If more than one LCMS, will they all have the same gas requirements?
•
Are they located in the same area/laboratory?
•
What are the distances from generator to LCMS?
•
Are there any special Health & Safety Regulations to be considered?
NOW YOU KNOW WHAT DECISIONS NEED TO BE MADE!
Peak Scientific Instruments Ltd
USING EXISTING HOUSE AIR SUPPLY
.
CAUTION!
•
If you select a gas generator for use with an existing house air
supply, make sure the air is of good quality and has the capacity to
supply the correct flow and pressure to the gas generator.
•
You must also ensure that the air supply will not contaminate the
generator or the LC/MS System – it must be
Clean, Dry and Oil – free
•
The generator should only ever be connected to a clean, dry and oilfree source of compressed air. If in any doubt, do not use this
source of air.
•
A regulated minimum pressure of 120 psig is required for the
generator to operate correctly.
NB. Contaminated air supplies are a common source of problems!
Peak Scientific Instruments Ltd
USING EXISTING OR NEW PIPEWORK?
CAUTION!
•
.
Is the generator to be connected to existing or new pipework?
•
If you plan to use existing pipework, has it been pressure/leak tested by a
competent, qualified technician?
•
Can you guarantee that it is clean and free of contaminants?
•
What is the i.d/o.d of the tubing?
•
Do you know which material the tubing is made from?
•
If in any doubt, do not use this existing pipework – use new tubing of the
correct internal diameter and material type.
NB. Contaminated pipework is a common source of problems!
Peak Scientific Instruments Ltd
WHICH GAS MANAGEMENT SYSTEM WILL BE BEST FOR MY
LAB AND MY LCMS SYSTEMS?
•
In house gas x
•
Liquid Nitrogen Dewar x
•
Cylinder gas x
•
Industrial gas generator √
•
Laboratory gas generator √
So if I choose a generator, what are the options and how do I decide
which is best for me?
Peak Scientific Instruments Ltd
SO HOW DO I DECIDE WHICH GENERATOR?
Let me show you five gas generator possibilities:
Single LC/MS gas generator
1.
2.
3.
With internal (built-in) compressors
With separate air compressor system
With separate air system and possibility to upgrade
Multi LC/MS gas generator
4.
5.
With separate air system and individual nitrogen generators
(one for each LCMS system)
With separate air system and one high capacity nitrogen
generator (enough to supply all systems running at full
flow simultaneously)
Peak Scientific Instruments Ltd
Notes :Use supplied tubing to connect Generator to LC/MS
where possible
SINGLE LCMS SYSTEM
Supply Line Size
Distance "L"
0 - 10 m
10m - 30m
30m - 50m
Line Size (OD) 1/4" (6mm) 3/8" (10mm) 1/2" (12mm)
NITROGEN GENERATOR
WITH INTERNAL
COMPRESSORS
NitroGen
Peak Scientific
I
O
N2
Max Distance (L)
Nx10DR Nitrogen Generator
System Installation Guide
Drawn
Single System Set-up
Nx10DR Generator
Date
SGM
Doc No
06-04-07
IG-013-01
Peak Scientific Instruments Ltd
SINGLE LCMS SYSTEM
Notes :Use supplied tubing to connect Generator to LC/MS
Supply Line Size
Distance "L"
Line Size (OD)
0 - 30 m
3/8" (10mm)
30m - 50m
1/2" (12mm)
AIR COMPRESSOR
NITROGEN GENERATOR
AirGen
Peak Scientific
I
O
N2
PEAK
AIR
PEAK
S C I E N T I F I C
S C I E N T I F I C
Max Distance (L)
Ax20DR Compressor
NM20Z
Generator
System Installation Guide
Drawn
NM30L System Set-up
Ax20DR Compressor
Date
SGM
Doc No
06-04-07
IG-017-01
Peak Scientific Instruments Ltd
SINGLE LCMS SYSTEM WITH
POSSIBLITY OF FUTURE UPGRADE
Supply Line Size
Distance "L"
Line Size (OD)
0 - 30 m
3/8" (10mm)
30m - 50m
1/2" (12mm)
Notes :Compressor should be 10 Barg Model with Dryer
Receiver should be adjacent to Compressor
Use supplied tubing to connect Generator to LC/MS
Pressure
Regulator
(8 Barg)
1/2" Line
10
5
15
20
0
25
AIR
A ir C o m pressor
N2
PEAK
PEAK
S C I E N T I F I C
Max Distance (L)
NRV
Air Compressor
(Atlas Copco SF1FF)
S C I E N T I F I C
Air Receiver
(125 Ltr)
NM30L
Generator
System Installation Guide
Drawn
NM30L System Set-up
Single System
Date
SGM
Doc No
06-04-07
IG-015-01
Peak Scientific Instruments Ltd
Supply Line Size
Distance "L"
No of Generators
Line Size (OD)
0 - 30 m
4-8
2-3
30m - 50m
2-3
4-8
Max Distance (L)
3/4"
3/8"
1/2"
1/2"
(10mm) (12mm) (12mm) (20mm)
Compressor Selection
No of Generators
1
2
3
4-5
6-7
8
Compressor
SF1 FF SF2 FF SF4 FF SF6 FF SF8 FF SF11 FF
Air Receiver (Ltrs) 127
127
250
500
700
1000
Notes :Compressor should be 10 Barg Model with Dryer
Receiver should be adjacent to Compressor
Use supplied tubing to connect Generator to LC/MS
Drop Lines at additional
Generator Locations
(3/8" or 10mm)
25
0
20
5
10
AIR
15
1/2" Line
Pressure
Regulator
(8 Barg)
A ir C o m pressor
N2
PEAK
PEAK
S C I E N T I F I C
S C I E N T I F I C
NRV
Air Compressor
(Atlas Copco SFxFF)
Air Receiver
See Note
NM30L
Generator
MULTI LCMS SYSTEM WITH
POSSIBLITY OF FUTURE UPGRADE
System Installation Guide
Drawn
NM30L System Set-up
Multiple Systems
Date
SGM
Doc No
06-04-07
IG-018-01
Peak Scientific Instruments Ltd
MULTI LCMS SYSTEMS WITH POSSIBLITY OF FUTURE UPGRADE
Selection Table
No of Instruments 1 - 2
3-4
5-6
7-8
9 - 10
Peak Generator
NM60L NM120L NM180L NM240L NM300L
Compressor
SF4 FF SF6 FF SF8 FF SF11 FF SF15 FF
Air Receiver (Ltrs) 250
250
500
700
1000
Supply Line Size
Distance "L"
No of Instruments
Line Size (OD)
Max Distance (L)
30m - 50m
0 - 30 m
7+
7+
1-3
1-3
4-6
4-6
3/8"
1/2"
3/4"
1/2"
3/4"
1"
(10mm) (12mm) (20mm) (12mm) (20mm) (25mm)
Notes :Compressor should be 10 Barg Model with Dryer.
Generator and Receiver should be adjacent to Compressor.
Generator Selection based on maximum 30Litres/min demand.
For instruments less than 30l/min apply formual g = Nx(d/30)
where g is Virtual No of Instruments,
N is Actual Number of Instruments,
d is actual Gas Demand.
OUTLET
Drop Lines at additional
Instrument Locations
(1/4" or 6mm)
INLET
Pressure
Regulator
(8 Barg)
Line size as per
Compressor Outlet
10
5
NRV
Local Regulator
(Optional)
15
20
0
25
10
5
Air Compressor
Air Receiver
15
20
0
25
NMxxxL
Generator
System Installation Guide
Drawn
NMxxxL System Set-up
Muliple LC/MS
Date
SGM
Doc No
06-04-07
IG-020-01
Peak Scientific Instruments Ltd
WHAT DO GAS GENERATORS LOOK LIKE?
NM30L
Can be wall mounted
or floor standing
NM30LA
Floor standing
N110DR
Floor standing – fits under most
standard lab benches
THESE ARE ALL DESIGNED FOR SINGLE LC/MS SYSTEMS AND ARE INTENDED TO BE
LOCATED CLOSE TO THE INSTRUMENTS IN THE LAB
Peak Scientific Instruments Ltd
ARE THERE ANY OTHER CONSIDERATIONS?
•
General Surrounding Environment
•
Location – Free Air Space
•
Temperature (5-25°C for internal compressors)
•
Air Conditioning on 24/7?
•
Relative Humidity – Max 70%
•
Altitude – Max 2000 metres
•
Electrical requirements – 230V ± 10% (50/60Hz)
•
Local Health & Safety Regulations
•
Noise <59dB (A) for internal compressors
•
Maximum outlet pressure is 100psi
Peak Scientific Instruments Ltd
WHO WILL INSTALL THE GAS MANAGEMENT SYSTEM?
•
This will vary from country to country
•
Always make sure you know your responsibilities
•
Refer to the site prep guides from the manufacturer(s)
•
Check that there are no health & safety obstacles
•
Inform FM people and anyone likely to be affected
•
Fulfil those commitments prior to installation
•
Agree what has to be done with the installation engineer
•
Set clear expectations – no surprises
•
Carry out an operational check with the engineer
•
Ensure everything works prior to engineer departing
Peak Scientific Instruments Ltd
WHAT IF THE GENERATOR STOPS WORKING?
•
You need to think ahead how you will maintain your system
•
What is your anticipated usage?
•
What is the required uptime?
•
How many PMs will be required annually?
•
Will you buy multiple years service up front?
•
Is there a special budget required?
•
Is a service plan good value for money versus a dewar?
•
What is the return on investment over 5 years?
•
Can I work on a time and materials basis?
Peak Scientific Instruments Ltd
WHAT IF THE GENERATOR STOPS WORKING?
•
Peak Scientific service plans available to purchase along with generator or
retrospectively
•
Peak Scientific takes full responsibility for all generator service
•
All work carried out by Peak Scientific engineers
•
Priority response for clinical customers or customers with Peak Scientific
complete service plan or warranty
•
Normally within 48 hours or sooner depending on customer location
•
Peak has >99% first time fix rate within 48 hours
Peak Scientific Instruments Ltd
HOW MUCH WILL A GAS GENERATOR COST TO RUN?
Return on Investment Calculator
Enter Values
Cost of Replacement Cylinder
Rental Charge
Monthly Delivery Charge
€ 15.00
€ 20.00
€ 5.00
Cost of Monthly Labour to Change
Cylinders
Hours Worked Per Day
Days Worked per Week
€ 150.00
9
5
Number of Cylinders per Week
5
Number of Cylinders per Month
20
Running Costs
Per Month
Cost of
NM30LA
Return on Investment
€ 855.00
€
13,592.00
16
Months
Peak Scientific Instruments Ltd
Return on Investment Analysis
50
40
Equity (€000's)
30
20
10
0
-10
1
4
7
10
13
16
19
22
25
28
31
34
37
40
43
46
-20
-30
-40
-50
-60
Time
Month
Generator
Cylinder Supply
49
52
55
58
61
Peak Scientific Instruments Ltd
THE DESIGN OF LC/MS SYSTEMS CONTINUES TO EVOLVE VERY
RAPIDLY AND THEY ALL HAVE DIFFERENT GAS REQUIREMENTS
Scientists are continually looking for
•
Better qualitative and quantitative performance
•
More sensitivity
•
Improved resolution
•
Better productivity and efficiency
•
New LCMS models are introduced every year
This often means Peak Scientific needs to produce a new generator to match the needs
of the latest LCMS system
Peak Scientific Instruments Ltd
THE PEAK SCIENTIFIC APPROACH TO GAS GENERATORS FOR LC/MS
•
Which LCMS manufacturer and model?
•
Designs and specifications vary from model to model and so do
the gas requirements!
•
What is the type of instrument?
•
Single or triple quad, TOF etc...?
•
What is the application – ESi or APCi or both?
In summary –
The Peak Scientific approach is to design and manufacture bespoke
generators which exactly match the gas requirements of the mass
spectrometer application
Peak Scientific Instruments Ltd
GAS GENERATORS – OUR ONLY BUSINESS
•
Bespoke gas generators for the analytical instrument industry
•
Mainly supplying generators for LCMS & GC instruments
•
So Peak is a niche market supplier to those OEMs
•
Peak manufactures high purity nitrogen, hydrogen and zero air
generators as well as some others for TOC, purge gas and
calibration gas applications
•
Our main focus is on supplying quality products backed up with
worldwide service and support
•
And of course, most important of all, as a specialist company in the
gas generator market, we are proud of our reputation for first class
CUSTOMER SATISFACTION ..................wherever you are