Transcript Document

Sarcoma Research Report
Site Specific Group Meeting
Tuesday 10th February 2015
Maxine Taylor
Senior Research Delivery Manager
Delivering clinical research to
make patients, and the NHS, better
Content of report
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Overview of network changes
Overview of research activity
New studies for the portfolio
Role research leads
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Introduction
• NIHR Clinical Research Network merged all cancer
research networks with all other clinical research
networks in England on 1st April 2014
• CRN - West of England is one of 15 new networks
• This new geography does not map exactly to the site
specific group geography. It now includes
Gloucestershire and Swindon but no longer includes
Taunton and Yeovil
• Taunton and Yeovil are served by the CRN – South West
Peninsula
• I will work closely with my counterpart in South West
Peninsula to support this SSG in full
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Map showing the 15 Clinical Research Networks in England
West of England
• Population 2.4 million
• - Budget £13.2 million
• - 7 Acute Trusts
• - 2 Mental Health Trusts
• - CCL Principal Treatment Centre
• - Small core support team based at
host in Bristol
• Research will follow patient
pathways regardless of network
geography
Purpose of the network
• Translation of national workstreams and objectives (generic
and specialty specific) with strategic oversight of research
activity within the geography of CRN - West of England in
terms of:
– Portfolio
• Balance, new studies, feasibility, industry trials
– Performance
• Targets, support timely set up, support timely
recruitment
– People
• Skill mix, workforce flexibility, resources, training
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CRN - West of England Management
Model
• Division
1
• Division
5
Maxine Taylor
Mary Griffin
Senior RDM
Workforce
Development
RDM, RM&G
and Industry
Lead
Mary Perkins
Chief Operating Officer
• Divisions
3&4
Chantal Sunter
Ruth Allen
RDM
RDM
PCPIE and
Comms Lead
Business
Intelligence lead
• Divisions
2&6
Network Clinical Divisions
Division 1
• Cancer
Division 2
• Diabetes
• Stroke
• Cardiovascular
Renal
Metabolic & endocrine
Division 3
• Children
• Genetics
Division 4
• Mental Health
• Dementias & neurodegenerative diseases
• Neurology
Division 5
• Primary care
research
• Oral & dental
• Musculoskeletal
Ageing
Division 6
• ENT
• Surgery
• Respiratory
• Critical care
• Hepatology
Anaesthesia & pain management
Critical care
Opthalmology
Infectious diseases
Gastroenterology
Reproductive health & childbirth
Haematology
Health services
Dermatology
Public Health
The Clinical Team
Dr Steve Falk
Clinical Director
6 Divisional Clinical Leads
Prof Hugh Barr for Div 1
30 Specialty
Leads
Sub Specialty
Leads
Sue Taylor
Network
Consultant Nurse
Clinical
Research Teams
NIHR CRN High Level Objectives
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Set up as fast as you can
Recruit as many and as fast as you can
All organisations involved
Commercial and non commercial portfolio studies
Cancer specialty specific objectives
• Recruitment overall at 20% cancer incidence
• Recruitment to interventional studies at 7.5% of cancer
incidence
How important is cancer on our patch?
Research staff WTE per
division
Div 1
58
67
Div 2
Div 3
23
34
17
20
21
Div 4
Div 5
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Div 6
Generic
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Cancer incidence 9544
242 recruiting studies
£2 million (16%)
Funding per incident case
approx £220
Funding per recruit £800
Exceeded both recruitment
targets for last 2 years
Largest non commercial
portfolio
Benefit from continued good
national and international links
West of England specialty portfolio compared to national
Surgery
Stroke
Respiratory disorders
Reproductive health and childbirth
Renal disorders
Public health
Primary Care
Oral and dental health
Ophthalmology
Neurological disorders
Musculoskeletal disorders
Metabolic and endocrine disorders
Mental Health
Injuries and emergencies
Infectious diseases and microbiology
Hepatology
Health services and delivery research
Haematology
Genetics
Gastroenterology
Ear, nose and throat
Diabetes
Dermatology
Dementias and neurodegeneration
Critical care
Children
Cardiovascular disease
Cancer
Anaesthesia, perioperative medicine and pain
Ageing
Total studies 3827
WE total 546
=14%
WE portfolio
National portfolio
0
100
200
300
400
500
600
700
800
CRN: West of England Performance against Specialty goals 14/15 (Apr 2014 Dec 2014)
Recruitment to Sarcoma studies by study design type by CRN: West
of England partner organisations (Apr 14 - Dec 14)
9
8
7
6
Recruits
5
5
4
7
3
2
4
3
3
1
1
0
Gloucestershire Hospitals
NHS Foundation Trust
Great Western Hospitals
NHS Foundation Trust
Royal United Hospital Bath
NHS Trust
Interventional
No recruitment at Taunton or Yeovil
Observational
University Hospitals Bristol
NHS Foundation Trust
Weston Area Health NHS
Trust
Recruiting studies 2014-15
Gloucestershire Hospitals NHS Foundation Trust
BRIGHTLIGHT: The 2012 TYA Cancer Cohort Study
Great Western Hospitals NHS Foundation Trust
BRIGHTLIGHT: The 2012 TYA Cancer Cohort Study
Royal United Hospital Bath NHS Trust
BRIGHTLIGHT: The 2012 TYA Cancer Cohort Study
University Hospitals Bristol NHS Foundation Trust
BRIGHTLIGHT: The 2012 TYA Cancer Cohort Study
Euro Ewing 2012
Pharmacokinetic variation and toxicity in Ewing's sarcoma
STS 2006 03 (NRSTS)
Weston Area Health NHS Trust
BRIGHTLIGHT: The 2012 TYA Cancer Cohort Study
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7
3
3
4
4
8
4
1
1
2
1
1
Potential new studies
• ISKS study - The International Sarcoma
Kindred Study: a global multi-site prospective
cancer genetics study
• rEECur - International randomised controlled
trial of chemotherapy for the treatment of
recurrent and primary refractory Ewing
sarcoma
National Clinical
Studies Groups
Psychosocial &
Survivorship
Brain
Tumours
Head & CSG
Palliative &
Neck
Supportive
CSG
Care
Sarcoma
CSG
Breast
Cancer
CSG
Imaging
Adv. panel
Lung
Cancer
CSG Upper GI
Biomarkers
Adv. panel
Cancer
CSG
Colorectal
Cancer
Consumer
CSG
Melanoma
Liaison
PPI
Kidney
CSG
Group
Cancer
Primary
CSG
Lymphoma
Care
Bladder
CSG
Cancer
Screening,
Testis CSG
Haematol.
Prevention &
Cancer
CSG Prostate
Gynae
Early Diagnosis
CSG
Children’s
Cancer
Cancer
Cancer &
CSG
CSG
Teenage &
Leukaemia
Young Adult
CTRad
(Radiotherapy)
Cancer Subspecialty Research Leads
• Within each network 13 subspecialty research lead roles
are identified, mapping onto the national Clinical Studies
Groups with the aim of:
– Providing link between local network and CSGs
– Promoting the research agenda to clinical colleagues
across the network and encouraging referrals
– Advising on portfolio planning locally
– Attendance at annual national meeting to discuss
portfolio planning and delivery and horizon scan for
new studies – first meeting 9th March 2015
– Supporting the research delivery manager for the
cancer specialty
• Role very similar to SSG Research Lead role
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LCRN (x15)
CRN WE Exec Board
Partnership Group
Clin. Advisory Group
Clinical Director
COO
Division 1 Clinical Lead
Division 1 RDM
[ +/- other clinical roles]
13 LCRN Subspecialty Leads:
•Brain cancer
•H&N cancer
•Lung cancer
•Breast cancer
•Sarcoma
•Skin Cancer
•Children/young people
•Upper GI cancer
•Colorectal cancer
•Urological cancer
•Gynae cancer
•Haem/lymphoma
•Pall/Supportive &
Psychosocial
Research Delivery
Teams
CRN – West of England Sub specialty
lead for breast cancer research
• Dr Adam Dangoor
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Contact & reference details
• [email protected]
• [email protected]
• http://csg.ncri.org.uk/portfolio-maps/
• https://www.edge.nhs.uk/Account/Index?ReturnUrl=%2f
• http://www.crn.nihr.ac.uk/can-help/fundersacademics/nihrcrn-portfolio/
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