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“bringing the best of nature to mankind”
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“bringing the best of nature to mankind”
• Our Facilities
• Product Development
• Making ACTIValoe®
• Topical Indications
• Qmatrix Processing
• Certification
• Innovation
• Services
Modified Aloe barbadensis Polysaccharide with Immunoregulatory Activity.
Zhihua Qiu, Ken Jones: Planta Medica 66, 1-5, 2000
The Farm at Aloecorp de Mexico
Gonzales, Mexico (120 km from Tampico)
Finishing & Packaging Facility
Lyford, Texas
 Aloecorp is a Vertically Integrated Aloe vera supplier
30,000
Metric Tons
25,000
Processing
• Processing capacity tripled since 2000
• Progressive Research Investment
• Patented processing methods
• Product & Process Innovation
20,000
15,000
10,000
5,000
0
2001
2002
2003
2004
2005
2006
An ECONET Family Company
Time, Temperature & Sanitation
TTS Quality Control takes into account all aspects of growing, harvesting
and processing Aloe vera raw materials to retain biological activity in the
finished product.
Time
• Minimal time from Harvest to Stabilization
• Minimal time of Processing
• Minimal Heat exposure
Temperature
• HTST pasteurization followed by cold storage
Sanitation
• Quality Assurance and Control on production floor
• In-process QC at every step
The Patented MAP Process
 Bioactivity Guided Process Development
Unigen Pharmaceuticals investigated the biological role of polysaccharide molecular weight in order to
Our Patented Aloe vera Processing
Immune Response
develop a processing method that would retain and enhance the biological activity of native aloe… resulting
in the patented processing method now used exclusively by Aloecorp.
16
U.S. Patent 6,436,679
12
8
4
0
Vehicle
-
• Activates macrophage
• Stimulates fibroblast proliferation
66, 1-5, 2000
30%
Growth Stimulation
Modified Aloe barbadensis Polysaccharide with
Immunoregulatory Activity. Zhihua Qiu, Ken Jones: Planta Medica
Vehicle
+
0.05
MAP
0.25
MAP
1.0
MAP
1.25
NG
2.5 NG
UVB Irradiated and DNFB Sensitized (mg/mL)
• Restores the UVB suppressed immune system
Publication
DNFB
Modified Aloe Polysaccharide
Native Aloe Gel
20%
*
*
*
P< 0.05
*
10%
0%
0
50
100
150
200
Concentration (mg/ml)
250
300
350
The Patented MAP Process
 Further studies on MAP bioactivity
Abstract conclusion
Aloe polysaccharides of 5 – 400 kDa exhibit
• Most potent macrophage activation
• Most phagocytic activity
• Most potent antitumor activity in vivo
G2E1 – Aloe vera crude methanol extract
G2E1D – Protein free MAP*
G2E1DS1 – Polysaccharide fraction < 5 kDa
G2E1DS2 – Polysaccharide fraction 5 kDa – 400 kDa (MAP**)
G2E1DS3 – Polysaccharide fraction > 400 kDa
Publication
Identification of Optimal Molecular Size of Modified Aloe Polysaccharides
with Maximum Immunomodulatory Activity. Sun-A Im et al.: International
Immunopharmacology 5, 2005
* MAP contains <5 kDa - > 2000 kDa PS
with 3X increase in max active PS fraction
** 1999 MAP paper identified a specific PS
MW max activity of 80 kDa. 2005 paper
did not determine specific MW max.
The Patented MAP Process
 Bioactivity Guided Process Development
 It has been noted that diverse results are reported in clinical studies using Aloe
vera. This may be explained in part by the observation that researchers commonly
do not determine the composition of aloe used in studies and, in particular, the
content or molecular weight distribution of acetylated mannan polysaccharides.
 Aloecorp is unique in this respect. Researchers using Aloecorp products are
provided with extensive analytical characterization of the test material. As a result,
consistent results have been published by these researchers.
 Most importantly, all Aloecorp products are manufactured by our patented
processing method based on the results of our bioactivity guided processing
research. The polysaccharide content and molecular weight distribution of every
batch of aloe produced by Aloecorp is determined by HPLC size exclusion
chromatography
The Patented MAP Process
 Aloecorp’s patented processing method
• Increases important MW fraction 3X
• Stabilized by HTST inactivation
• Guaranteed PS content
• Substantiated bioactivity
monosaccharide
cellulase
Immune Restoration
(% Recovery)
In vivo topical application
100%
75%
Modified Aloe Polysaccharide (MAP) 50 – 200kD
75%
50%
25%
6%
25%
15%
0%
5-10
10-50
50-200
200-2000
Polysaccharide Molecular Size (kD)
Timed inactivation of cellulase
The Patented MAP Process
Global Research
 Original research of Aloecorp’s Aloe vera products
• Antigenotoxic Activity
Carcinogenesis 1997
• Anticarcinogenic Activity
Carcinogenesis 1999
• Stimulates Antioxidant Production
Journal of Nutritional Science & Vitaminology. 2003 Aug
• Lowers Cholesterol
Journal of Nutritional Science & Vitaminology. 2003 Aug
• Stimulates Immune System
Planta Medica 1999
• Accelerates Wound Healing
Planta Medica 1999
• Aloecorp MAP Enhances Native Biological Activity of Aloe
International Immunopharmacology 2005
Topical Indications
Topical Indications
 Biologically Active Vehicle in Topical Applications
Journal of the American Podiatric Medical Association June 1989
 Accelerating Wound Healing
British Journal of Dermatology 2001
Journal of the Medical Association of Thailand 2000
Journal of Ethnopharmacology 1998
Journal of the American Podiatric Medical Association 1994
Journal of Dermatologic Surgery and Oncology
* Too many to list
 Wound Healing/Dermal Integument (Anti-aging)
Life Sciences 2003
Journal of Ethnopharmacology 1998
Molecular & Cellular Biochemistry 1998
Indian Journal of Experimental Biology 1998
Journal of the American Podiatric Medical Association 1994
Journal of the American Podiatric Medical Association 1989
Topical Indications
 Moisturizing Effect
Skin Research and Technology 2006
Association for Professionals in Infection Control and Epidemiology 2003
 Topical Immunomodulatory Activity
International Immunopharmacology 2005
Planta Medica 1999
The Journal for Investigative Dermatology 1998
Planta Medica 1989
* Too many to list
 Topical Anti-Inflammatory
Korean Journal of Dermatology 2004
Journal of Ethnopharmacology 1996
Journal of the American Podiatric Medical Association 1989
Journal of the American Podiatric Medical Association 1994
*Too many to list
Topical Indications
 Calcium and the Skin
Calcium plays a critical roll in epidermal cell differentiation, turnover and wound
healing. There is some evidence that cell turnover can be up-regulated by increasing
calcium availability topically. Calcium has also been shown effective in treating dry
skin due to its role in regulating lipid barrier processes. The National Cancer
Research Institute has reported that people with low skin calcium experience greater
premature aging of the skin and incidence of skin cancer.
Aloe contains approximately 7% calcium by dry weight and this content is thought to
play a role in the accelerated wound healing properties of aloe, moisturizing effect
and anti-carcinogenic effects. For this reason aloe should be a critical component of
cosmetic and cosmeceutical applications such as:
• Stimulation of post-dermabrasion wound healing J Dermatol Surg Oncol 1990
• OTC exfoliation products (wound healing and moisturizing)
• Anti-aging and skin cancer protection
Qmatrix
TM
Processing
Another Innovation… Only from Aloecorp
 Aloecorp’s new Qmatrix™ Processing is the latest step in our effort to
“bring the best of nature to mankind”.
• Qmatrix™ is an patented aloe manufacturing process
• A combination of our patented Modified Aloe Polysaccharide (MAP) process
and patent pending Low Temperature/Short Time (LTST) drying process.
• Qmatrix™ Processing… Designed to produce the highest quality Aloe vera
powder available
• Only from Aloecorp
Qmatrix
TM
Processing
Another Innovation… Only from Aloecorp
 Published studies show that LTST dehydration technology provides
superior retention of heat labile components, color & flavor characteristics
• Gentle low temperature/short time drying
• Superior sensory attributes retained (Academic study)
• Superior retention of nutrients and bioactivity (Academic study)
• Atmospheric pressure (no vacuum)
• Energy efficient (Green)
• Environmentally friendly (Green)
• Superior solubility characteristics
• New proprietary products due to versatility
Qmatrix
TM
Processing
 Solubility, bulk density and moisture
absorbance are positively affected
 Dispersion & dissolution improved
20
0.200
Solubility (min)
for application
12
8
0.880
4
0.180
Moisture Absorbance (%)
 Bulk density optimized
16
0.160
0.140
0.120
0.100
0.080
0.060
0.040
0.020
0.840
0.000
0
SD-80
QM-80
Low Agitation
0
QM-10
Moderate Agitation
50
100
150
0.800
SD-80
Minutes
stirring
Agitation Low
Agitation
moderate
SD-80
19
8
QM-80
4.5
3.3
1
1
250
300
QM-80
QM-10
0.760
 Moisture absorbance rate
reduced
0.720
SD-80
QM-10
200
Time (min)
QM -80
QM -10
350
 Qmatrix™ Processing Product Advances (8010XQ)
Superior Quality Characteristics
Superior Physical Characteristics
 Sensory attributes (better taste and color)
 Improved solubility
 Color stability (after reconstitution)
 Targeted bulk density
 Shelf life (testing in process)
 Improved flow ability
 Reduced thermal degradation
 Less hydroscopic
 Reduced microbial degradation
 Homogeneous dry matrix
New From Aloecorp
 Proprietary blends and Turn-key products possible
 Patent submitted November 2004
Attorney Docket: ALOE.01/PR
Express Mail No.:
DEHYDRATION OF FOOD COMBINATIONS
FIELD of the invention
The invention relates to the drying of blends of
aloe, foods or food extracts, herbs or herb
extracts, supplements, and the like.
New From Aloecorp
Qmatrix™ - O2P™ Aloe vera oil powders
 Qmatrix – O2P Processing enables aloe & oil mixtures to be dried as
stable, unique powders
Concept
• Combinations of nutritional, functional and therapeutic foods, herbs and excipients
are combined with aloe to produce proprietary products
• Liquid combinations dried by this process are stabilized in a homogeneous dry matrix
• Patented oil to powder conversion process
• Turn-key proprietary products can be developed
• Offers an alternative tablet or capsule delivery form
• Transforms most edible oils, pastes, gels, liquids into a free-flowing powder
New From Aloecorp
Qmatrix™ - O2P™ Aloe vera oil powders
 Multiple Applications
• Nutraceuticals
• Food fortification
• Cosmetics, personal care
• Animal feed, pet food fortification
Certified Products
 Aloecorp products are Certified for the Quality and Purity you need
IASC
• Aloecorp products first Certified in 1989
• Currently have 26 IASC Certified products
ISO 9001
• ISO Certified since 2003
Organic
• Powder products certified Organic in Texas and Europe
Kosher
• Certified Kosher since 1999
Halal (2005)
 Aloecorp expects to be cGMP by 2007
SA
QA&C
Scientific Affairs
 Innovative & service oriented… we are always working to provide our
customers with the best product and support
Scientific Affairs
• Original research
• Technical consultation
• Indications library
• Quality Assurance
• Quality Control
• Analytical labs
• International support structure
• Europe, Asia, Mexico, USA
Vertically Integrated
The World’s Leading Supplier of Quality Aloe vera
Summary
• Leading the Industry in Quality & Scientific advances
• Bioactivity guided process development
• Original research on the product we supply
• Investment and innovation
• Certified products
• Commitment to product development
• Scientific support and services
ALOECORP
“bringing the best of nature to mankind”
Thank You
CEO
Peter Hafermann
Chief Science Officer
Ken Jones
Director of Business Development
Barb Apps
VP Sales and Marketing
Wayne McCune
VP International Sales
Mick Anderson
Sales
Jeff Barrie
Bob Smith