Transcript Document

BIOL 4320
Cellular Biology
Rachna Sadana
Learning Goal
Learning
Objectives
1. List Hallmarks of cancer
cells
2a. Explain what are telomeres and
why are these important (end
replication problem)
2b. Explain mechanism of action of
various cancer drugs.
Demonstrate
knowledge of
why cancer cells
have replicative
immortality?
3. Explain how telomerase
inhibitors can work as anticancer drugs?
4. Analyze data from a
paper showing telomerase
activity in cancer cells.
Taxonomy
Levels
Activity
Formative
Assessment
1. Remember
1. Reading assignment outside
class
1. Online quiz part 1 on
BbL (Sunday night)
2. Understand
2. Video lecture outside the
class
2. Post on discussion
board on BbL (Sunday
night)
3. Apply
3. Draw a model showing what
happens if telomerase is active
or inactive
3. Scenario questions inclass
4a. Data Analysis assignment as
homework assignment
4. Analyze
4b. Data analysis assignment for
in-class discussion
4. Homework assignment
5. in-class discussion on
estrogen receptor signaling and
inhibition by Herceptin
5. How Herceptin and taxol
work differently than
telomerase inhibitors?
5. Evaluate
6. Design an experiment to test
various compounds to screen
for cytotoxic activity and
telomerase inhibitory activity.
6. Create
role of tubulin in cell division and
interference in cell cycle by taxol
Mechanism of action of telomerase
inhibitors and side effects
6. Take home assignment
5. Evaluate pros and cons
of Herceptin, taxol and
telomerase inhibitors
6. Take home assignment
in class
LO 5
•
LO 3
•
LO 4
•
•
•
S
Su
Watch
video
lecture
or
guided
reading
assignment
Online quiz
and
Post
response
to prompts
on
discussion
board
M
Interrupted
lecture
Group quiz
Application
activity on
telomerase
inhibitord
T
Instructor
provides
feedback
to
student’s
posts.
•
•
W
Problem
set as
home work
on data
analysis
Review of
home work
assignment
Data Analysis
from second
paper
R
•
F
Free day!!
S
Su
Watch
video
lecture
or
guided
reading
assignment
Post
response
to prompts
on
discussion
board
M
Interrupted
lecture
Discussion
on various
cancer
drugs (Jigsaw)
Compare
and contrast
various
cancer
drugs
T
•
W
Experimental
design Take
home
assignment
due in a
week
Instructor
provides
feedback
to
student’s
posts.
LO 4
LO 6
LO 2b
LO 1 and 2a
Out-of class
Week 1
•
Week 2
Interrupted
lecture on
experimental
design
Discussion on
homework
assignment
R
F
Free day!!
Reflection: How am I floating?
6/17/2015
??
June 2016