Transcript Rubrik, Arial Bold 32 pt

Karolinska Institutet
– a medical university
Research
Research at KI
 KI is Sweden’s only medical university
and the country’s largest centre for
medical education and research.
 Karolinska Institutet accounts for over
40 per cent of the medical academic
research conducted in Sweden.
© Magnus Aldemark
Name Surname
20 July 2015
2
Research: from molecule to patient
 22 departments
 600 research groups
 1,500 researchers/teachers,
including over
300 professors
 2,000 doctoral students
© Erik G Svensson
© Lennart Nilsson / Scanpix
Name Surname
20 July 2015
3
Education and research at KI, 2011
“Research” indicates total assets, excluding
premises and ALF funding.
KI Solna campus
1,130 annual FTE students
Research SEK 1,423 million
1,817 annual FTE employees
Danderyds Hospital
189 annual FTE students
Research SEK 33 million
31 annual FTE
employees
Karolinska University
Hospital
1,330 annual FTE students
Research SEK 1,218 million
1,143 annual FTE employees
KI Huddinge campus with
Karolinska University Hospital
2,940 annual FTE students
Research SEK 850 million
1,074 annual FTE employees
Stockholm South
General (Söder) hospital
226 annual FTE students
Research SEK 39 million
44 annual FTE employees
2011 Annual report
Name Surname
20 July 2015
4
Over 80 per cent of KI revenue goes into
research
Bachelor’s/Master’s
education, 17%
Research and doctoral
education, 83%
2011 Annual report
Name Surname
20 July 2015
5
Research potential
 Clinical research
 Epidemiology
 Science for Life Laboratory
© Marcus Erixson
Name Surname
© Elisabet Omsén
© Pierre Zoetterman
20 July 2015
6
Research potential: Clinical research


More than half of KI’s 22 departments are in
or adjacent to Stockholm’s teaching hospitals
The proximity of basic and clinical research
makes possible research of a translational
nature, where observations made at the
clinical level feed new ideas for research,
and where new experimental findings can be
quickly turned to the benefit of the patients
© Marcus Erixson
Name Surname
20 July 2015
7
Research potential: Epidemiology




Sweden is a goldmine for epidemiological
research
 Population registers, disease registers
 KI Biobank, Swedish Twin Registry,
LifeGene
Growing competence in biostatistics
KI is a global leader
Research fields include:
 Cancer
 Cardiovascular diseases
 Infections
 Inflammations
 Social inequality
Name Surname
© Elisabet Omsén
20 July 2015
8
Research potential: SciLifeLab


The Science for Life Laboratory is a national
resource centre and world-class laboratory for
large-scale bioscience research in the
following principal areas:
 Genomics
 Proteomics
 Bioimaging
 Bioinformatics
SciLifeLab is the result of a joint investment
with the Royal Institute of Technology and
Stockholm and Uppsala universities
© Pierre Zoetterman
Name Surname
20 July 2015
9
Scientific publications, 2010



Approx. 3,500 scientific articles and 1,000
other publications were authored by
researchers at Karolinska Institutet
Approx. 60 per cent have co-authors from
other countries
The citation rate for articles from Karolinska
Institutet is 50 per cent higher than the world
average
© Marcus Erixson
Name Surname
20 July 2015
10
Publications, 2001 – 2010
Number
6000
5000
Other
Letter
Editorial material
Meeting/Abstract
Review
Article
4000
3000
2000
1000
0
2001 2002 2003 2004 2005 2006 2007 2008 2009 2010
2011 Annual report
Name Surname
20 July 2015
11
Co-publications
100%
90%
80%
70%
60%
50%
40%
30%
20%
10%
0%
2001 2002 2003 2004 2005 2006 2007 2008 2009 2010
Co-author outside KI
Co-author outside
Sweden
Co-author in
Sweden
Given the inevitable delay in the release of data, figures for 2011 are not included.
2011 Annual report
Name Surname
20 July 2015
12
Field normalised citation scores, 2001 – 2010
Score
1.75
KI
1.50
1.25
1.00
Global
average
0.75
2001 2002 2003 2004 2005 2006 2007 2008 2009 2010
2011 Annual report
Name Surname
20 July 2015
13
Research funding
Total, 2011: 4,452 SEK million (2010: 4,405)
Government
appropriations
37%
Swedish foundations &
org.
15%
Non-Swedish
foundations and org.
3%
EU
5%
Swedish companies
4%
Financial revenue
1%
Non-Swedish
companies
2%
KI funds
1%
County and municipal
councils
10%
Research councils
15%
Other government
funding
7%
2011 Annual report
Name Surname
20 July 2015
14
Research funding, 2002 – 2011
SEK million
3,000
2,500
2,000
1,500
External
Government
1,000
500
0
2002 2003 2004 2005 2006 2007 2008 2009 2010 2011
2011 Annual report
Name Surname
20 July 2015
15
Revenue from the EU and USA, 2004 – 2011
SEK million
25.0
20.0
15.0
EU
10.0
American foundations
and organisations
5.0
0.0
2004 2005 2006 2007 2008 2009 2010 2011
2011 Annual report
Name Surname
20 July 2015
16
The Board of Research
 Strategies
22 Departments
 Research funding and
 Research
recruitment
 Doctoral education
 Research networks
 Research centres
 Core facilities
 Career service for junior faculty
 Laboratory biosafety and ethics
© Marcus Erixson
Name Surname
20 July 2015
17
Core facilities in many fields







Biobanks
Bioinformatics and biostatistics
Clinical trial centres
Experimental models
Expression analysis
Genomics
Imaging and visualization
techniques
 Proteomics
 Biosafety laboratory (BSL-3)
© Erik G Svensson
Name Surname
20 July 2015
18
National centres
 CERIC – The Centre for
Research on Inflammation and
Cardiovascular Disease (Linné)
 CRisP – The Linné Centre for
Prevention of Breast and
Prostate Cancer (Linné)
 DBRM – The Centre of
Excellence in Developmental
Biology for Regenerative
Medicine (Linné)
 STARGET – a cancer research
network (Linné)
 The Human Regenerative Map
(Linné)
Name Surname
 ARC – The Aging Research
Centre (FAS)
 The Centre for Research on
Hearing Loss in Working Life
(FAS)
 CHESS – Centre for Health
Equity Studies (FAS)
 Stockholm Brain Institute
(VINNOVA)
20 July 2015
19
Strategic research areas
Financed through the government’s strategic programme, 2009–2014







SRP Cancer
SRP Diabetes
– in association with Umeå University
SRP Epidemiology
SRP Molecular biosciences(SciLifeLab)
– in association with the Royal Institute of
Technology and Stockholm University
SRP Neuroscience – in association with
Umeå University
SRP Stem cells and regenerative medicine
SRP Care sciences
– in association with Umeå University
© Sofia Lindberg
Name Surname
20 July 2015
20
Research fields
KI’s research spans a broad
field, from basic experimental
research to patient-end
research and care sciences.
© Erik G Svensson
Name Surname
20 July 2015
21
Research fields
From basic experimental research to patient-end research in the
fields of









Cancer and haematology
Cell, molecular and structure biology
Circulation and respiration
Developmental biology, stem cells,
reproductive, regenerative and reparative
medicine
Endocrinology and metabolism
Epidemiology and public health
Care sciences
Immunology, infection, inflammation and
microbiology
Neuroscience, psychiatry and behavioural
science
Name Surname
© Erik G Svensson
20 July 2015
22
Research fields
Cancer and haematology
 Basic research into mechanisms for the
origin and development of cancer
 Development of therapies; e.g. hormone,
immune and gene therapy
 Clinic-centred research on diseases of
the blood and blood-forming organs
 Epidemiological research on underlying
causes
 Optimisation of radiotherapy
 Diagnostic development
 Life quality
© Lennart Nilsson / Boehringer Ingelheim / Scanpix
Name Surname
20 July 2015
23
Research fields
Cell, molecular and structure biology
 Function and composition of cells,
proteins and DNA
 Research in all disease areas
Special resource:
 Science for Life Laboratory
– for large-scale analysis in the fields of
 Genomics
 Proteomics
 Bioimaging
 Bioinformatics
© Lennart Nilsson / Scanpix
Name Surname
20 July 2015
24
Research fields
Circulation and respiration




Long tradition of strong, clinical research
Supplemented strongly with basic research in
later decades
Today has a clear orientation towards
translational research
Research focuses on
 Cardiovascular diseases
 Atherosclerosis
 Heart failure
 Other vascular diseases, such as diabetes
complications and kidney failure
 Lung medicine
 Asthma
 COPD
Name Surname
© Lennart Nilsson / Scanpix
20 July 2015
25
Research fields
Developmental biology, stem cells, reproductive,
regenerative and reparative medicine
From experimental stem cell
research…
…to clinical application in
reparative medicine
 International leader in
developmental biology research
 Strong clinical expertise in cell
therapy and transplantation
medicine
 Broad-based research in tissue
and locomotion – diseases,
therapy and rehabilitation
Name Surname
Research focuses include
 Parkinson’s disease
 Spinal injuries
 Diabetes
 Diseases of the musculoskeletal
organs
 Post-cardiac infarction tissue
damage
 Involuntary childlessness
 Medical rehabilitation
 Odontology
20 July 2015
26
Research fields
Endocrinology and metabolism
Overweight
 Outstanding research in both adult and
child obesity
 Close clinical links
Diabetes
 Basic diabetes research
 Research on symptoms and treatment
 Stem cell research
Cardiovascular diseases
 The significance of inflammation
 Blood lipids
 Gender aspects of diagnosis and care
© Lennart Nilsson / Scanpix
Name Surname
20 July 2015
27
Research fields
Epidemiology and public health
Research focuses include
 Cancer
 Cardiovascular diseases
 Neuropsychiatric diseases
 Infections and inflammations
 Links between common diseases and
life patterns and environmental factors
 Social inequality
 Insurance medicine
 Global health
© Lennart Nilsson / Scanpix
Name Surname
20 July 2015
28
Research fields
Care sciences
Care sciences cover prevention, care,
nursing and rehabilitation
 Research is done in five principal areas:
 Women’s and children’s health
 People who live with chronic diseases
 Elderly people with lowered activity and
participation
 Cancer and palliative care and nursing
 Health and healthcare research in
organisation and leadership
© Maskot
Name Surname
20 July 2015
29
Research fields
Immunology, infection, inflammation and
microbiology
Research focuses on
 Basal immunology and infection medicine
 Epidemiology, vaccine and prevention
 Global infections
 HIV, malaria, tuberculosis, pneumonia
 Inflammatory diseases
 Rheumatic arthritis and multiple sclerosis
 Immune deficiency and autoimmunity
 Allergies and eczema
 Asthma and COPD
 Cardiovascular diseases
Name Surname
© Lennart Nilsson / Scanpix
20 July 2015
30
Research fields
Neuroscience, psychiatry and behavioural science
Approximately 20 per cent of Karolinska
Institutet’s research is in the neuroscience field
Research focuses include
 The cognitive and motor functions of the
nervous system
 Mechanisms and treatment of neurological
and psychiatric diseases







Name Surname
ADHD and autism
Dementia and Alzheimer’s disease
Spinalcord injury
Schizophrenia
Suicide
Pain
Violence prevention
© Lennart Nilsson / Scanpix
20 July 2015
31
Doctoral education
Creates opportunities for
 In-depth subject knowledge
 Knowledge-exchange with worldrenowned researchers
 International exchange
Entails
 Own project work in an established
research team
 Supervision by senior researchers
 Courses at doctoral level
© Erik G Svensson
Name Surname
20 July 2015
32
Doctoral students, 2011
 2,133 active
 62% are women
 28% –29 years
 42% 30–39 years
 30% 40+ years
 409 new admissions
 61% are women
 46% –29 years
 36% 30–39 years
 18% 40+ years
© Erik G Svensson
Name Surname
20 July 2015
33
Doctoral schools
National schools in association
with other universities/university
colleges
 Health care sciences
 Clinical psychiatry
 Clinical cancer research
 Global health
 Registry-based research
 Hearing impairment in working
life
Name Surname
Local clinical doctoral schools in
association with the Stockholm
County Council
 General medicine
 Epidemiology
 Molecular medicine
 Psychiatry
20 July 2015
34
Broad programmes for doctoral education
 Allergy, immunology and
inflammation
 Cell biology and genetics
 Epidemiology
 Hearing, ears, language and
speech
 Infection biology
 Cardiovascular research
 Metabolism and endocrinology
Name Surname
 Environmental factors and
health
 Regenerative medicine
 Neuroscience
 Tumour biology/oncology
 Developmental biology and
cellular signalling
 Global health
 Healthcare sciences
20 July 2015
35
Doctoral education – 2 degrees
Licentiate degree
Licentiate seminar
About 2 years
Examination board
Licentiate thesis
PhD degree
Public defence
About 4 years
Half-time review
Doctoral thesis
Name Surname
20 July 2015
36
Public defences
Number
450
400
350
300
250
200
150
100
50
0
2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011
Men
Women
Total
2011 Annual report
Name Surname
20 July 2015
37
Board of Doctoral Education






Strategies
Rules and guidelines
Graduate schools
Research internships
KID funds
Dissertation committee
22 departments
 Research
 Doctoral education
© Marcus Erixson
© Marcus Erixson
Name Surname
20 July 2015
38
How is doctoral education financed?
 Doctoral studentships
 Doctoral grants
 ALF funds, scholarships, clinical employment or other
Financiers
 External grants
 Stockholm County Council
 Government faculty funds
 Companies
 Other organisations in related areas
Name Surname
20 July 2015
39
International exchange programmes
Karolinska Institutet has doctoral exchange agreements in place with, e.g.










USA – National Institute of Health and the University of Minnesota
Singapore – A*STAR and NUS, NTU
Japan – RIKEN Brain Science Institute
Kina – Peking University, Sun Yat-Sen, Fudan, Nanjing
Vietnam – Hanoi Medical University
Laos – Ministry of Health
Uganda – Makerere University
Finland – University of Helsinki
Ukraine – National Medical University
Belarus – Belarus Medical University
Name Surname
20 July 2015
40
Broad-based research collaboration
 Healthcare
 Swedish and overseas universities
 Private enterprise
© Keiko Naito
© Anders Kallersand
Name Surname
20 July 2015
41
Karolinska Institutet’s innovation system –
from research to commercial application




Karolinska Institutet’s innovation system
promotes collaboration with the private
sector
Supports researchers in their efforts to
convert their research results into new
products and services
Offers advice (e.g. on agreements and
patents), project management, financing
and business development support
Gives researchers access to extensive
networks in the pharmaceutical industry
and business
© Mike Kemp
Name Surname
20 July 2015
42