Transcript Folie 1

Organs affected with AIDS-lymphoid tissue
HIV in the nervous system AIDS dementia
Karposi Sarkoma
• First reported by Hungarian physician: Moritz
Karposi in 1872
• Multifocal cancer: dominant type is called
spindle cells: endothelial origin
• Typically in older man in Mediterranian rim
• In HIV-1: very aggressive: occurs in 20% of
infected homosexual man, only 2% in others
• Evidence that Herpes virus (HHV8) is necessary
is strong
Karposi Sarkoma
Karposi Sarkoma
Treatment of AIDS
• HAART: highly
efficient triple
combination therapy:
(2x anti-reverse
transcriptase,
1xprotease inhib.)
Viral decay on drug treatment
Resistance of HIV to protease inhibitors
HIV Infection is spreading over all continents
Immune Therapies/Prophylactic vaccine development
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Difficulties:
Rapid mutations in virus
Danger to cause an inappropriate immune
response
Necessity to target privileged sites
(mucosa, brain)
Small animal models not available
Ethical issues of vaccination: people
should adjust behaviour
Perspectives
• Prevention!!!!!
• Multiple steps in viral replication offer new
targets
“Innate Immunity”
Adelheid Cerwenka, PhD, D080
Theodor Boveri-Group
since April 2003
PhD students
Norman Nausch
Kai Zanzinger
Anja Schmidtke
Technician
Sandra Kosten