Transcript Tuberculosis

TUBERCOLOSIS
Agis Terzidis, Paediatrician
Spyridon Gialamas, Medical Doctor
SEMINAR ON TROPICAL AND TRAVEL MEDICINE AT TTCIH
IFAKARA 25 JUNE 2009
Estimated TB incidence rates, by country, 2007
Source: WHO
Trends in estimated incidence rates in nine subregions, 1990-2007
Source: WHO
Progress towards the 70% case-detection target
Source: WHO
Tuberculosis supranational reference laboratory network, 2007
Source: WHO
Countries that had reported at least one case of
extensively drug-resistant TB
Source: WHO
Global Fund commitments for TB control by region, as of end 2008
African Region
29% (US$ 1131 million)
Western Pacific Region
20% (US$ 755 million)
Region of the Americas
6% (US$ 229 million)
Southeast Asia Region
22% (US$ 867 million)
Eastern Mediterranean Region
10% (US$ 382 million)
European Region
13% (US$ 502 million)
Source: WHO
Objectives for 2006–2015 of the Working
Group on New TB Diagnostics:
• address existing gaps in knowledge that are
obstructing development of new diagnostic
tools
• develop and evaluate a portfolio of new
diagnostic tools and demonstrate their
impact
• implement new diagnostic tools and ensure
access to them
Source: WHO
Strategic plan for 2006–2015 of the Working
Group on New TB Drugs:
• Identification and validation of new targets for drugs,
and candidate compounds
• drug development
• planning and execution of more effective clinical trials,
including identification of improved biomarkers and
methods of assessing latent disease
• clear and efficient regulatory guidance
Source: WHO
Strategic plan for 2006–2015 of the Working
Group on TB Vaccines:
• maintain and improve BCG vaccination programmes.
The next generation of new vaccines introduced as an
addition to BCG vaccines
• expand discovery and translation research on
vaccines (“keeping the pipeline filled”)
• facilitate preclinical development of new vaccines
• build capacity at vaccine trial sites, providing
opportunities for training and capacity strengthening
AHSANTENI