Transcript Slide 1

Gene Regulation in Health in Disease (GRHD)
Research Center of Excellence at CSU
GRHD Logo is “under construction” by CSU Art Department
Gene Regulation in Health in Disease (GRHD)
Research Center of Excellence at CSU
GRHD: past, present and future
History of GRHD
Why GRHD is a Center/Cluster of Excellence?
GRHD development/future
Gene Regulation in Health in Disease (GRHD)
Research Center of Excellence at CSU
Center was launched in 2008 with $900,000 funding from
the Ohio Third Frontier Commission’s Ohio Research
Scholars Program.
Initiative of the 4 co-founding GRHD members:
Dr. Michael Kalafatis (CHM)
Dr. Anton A. Komar (BIO)
Dr. Barsanjit Mazumder (BIO)
Dr. Crystal M. Weyman (BIO): co-founding director
Currently brings together 15 faculty from 3 departments:
BIO – 9 faculty; CHM – 5 faculty; PHS; 1 faculty
Gene Regulation in Health in Disease (GRHD)
Research Center of Excellence at CSU
Vision Statement:
To enhance and integrate research focused on Gene Regulation in
Health and Disease leading to better understanding of the molecular
mechanisms controlling these processes and the identification of
therapeutic targets.
Gene Regulation in Health in Disease (GRHD)
Research Center of Excellence at CSU
Mission Statement:
To develop and support research focused on Gene Regulation in Health and
Disease.
To encourage and provide support mechanisms for the acquisition of
extramural funding.
To encourage and provide support mechanisms for the dissemination of
research results.
To create mechanisms to acquire resources to support research and student
training focused on Gene Regulation in Health and Disease.
To develop and expand partnerships with relevant public and private
community entities with similar interests.
To develop and promote Cleveland State University’s reputation as a local,
national and international leader in Gene Regulation in Health and Disease.
Gene Regulation in Health in Disease (GRHD)
Research Center of Excellence at CSU
External Advisory Committee:
Paul DiCorleto, Ph.D.
Staff, Institute Chairman
Lerner Research Institute, Cleveland Clinic
Toni Scarpa, Ph.D.
Former director of the
Center for Scientific
Review, NIH
Richard W. Hanson, Ph.D.
Leonard & Jean Skeggs Professor of Biochemistry
Department of Biochemistry, CWRU School of Medicine
Roy L. Silverstein, M.D.
John and Linda Mellowes Professor and Chair, Department of Medicine
Professor of Cell Biology and Physiology, Medical College of Wisconsin
George R. Stark, Ph.D.
Distinguished Scientist, Cleveland Clinic
Member of the U.S. National Academy of Science and Institute of Medicine and
Fellow of the Royal Society of London
Gene Regulation in Health in Disease (GRHD)
Research Center of Excellence at CSU
Membership
Criteria:
Non-tenured faculty shall have a strong record of publication in peerreviewed high impact scientific journals within the preceding five years.
Tenured faculty shall additionally have the following within the preceding
five years:
(a) served as Principal Investigator on a national grant awarded to CSU
and
(b) published at least three peer-reviewed scientific manuscripts as a
senior and/or corresponding author.
Gene Regulation in Health in Disease (GRHD)
Research Center of Excellence at CSU
Membership
Requirements:
All members, if not currently funded by a national grant, shall submit
at least one national grant per year.
All members shall submit grants for internal review by at least two members
of the GRHD executive committee or by one member of the executive
committee and one nationally funded/distinguished scientist.
All members are strongly encouraged to submit study section reviews of their
grants to the GHRD executive committee for review and additional feedback.
All members shall provide an annual research report to the executive
committee detailing grant activity, manuscript submission/publication, invited
seminars, poster presentations, service to the profession in the form of grant and
manuscript review, and completion of doctoral dissertation, MS thesis and
undergraduate independent study.
Faculty
GRHD faculty
18
Andy & Bin
Aaron & Tony
16
Sailen
14
Aimin & Xue-Long
12
10
8
6
(Crystal, Michael, Barsan, Anton) + (Valentin, Girish, Bibo, Roman)
4
2007
2008
2009
2010
2011
2012
2013
2014
2015
year
GRHD faculty
Planning/Executive Committee
Anton A. Komar
BIO
Crystal M. Weyman
BIO
Translational control
of gene expression
and protein folding.
Apoptosis (cell death).
Muscular
dystrophy
and cancer.
Michael Kalafatis
CHM
Barsanjit Mazumder
BIO
Blood
coagulation
and cancer.
Regulation of inflammation.
Atherosclerosis.
GRHD faculty
G. Valentin Boerner
BIO
Roman V. Kondratov
BIO
Chromosome segregation
during meiosis.
Circadian system
regulation, aging.
Bibo Li
BIO
Girish Shukla
BIO
Telomere (sections of
DNA at the ends of
chromosomes) function.
mRNA processing and
stability in relation to
prostate cancer.
GRHD faculty
Aimin Zhou
CHM
Xue-Long Sun
CHM
Interferon and RNase
L signaling. Diabetes,
cancer.
Glycoproteins. Chemistry
of portein modifications.
Antithrombotics.
Sailen Barik
BIO
Andrew Resnick
PHS
Cardiopulmonary Innate
Immunity. Viral infections.
Mechanotransduction
response in epithelial
cells. Biology of cilia.
GRHD faculty
Bin Su
CHM
Aaron F. Severson
BIO
Design
and
development of novel
anticancer drugs.
Chromosome dynamics,
production of normal
sperm and eggs.
Anthony Berdis
CHM
DNA
replication,
nucleoside analogs,
cancer.
GRHD: awards 2009-2013
Extramural funding, grants:
NIH (R01, R15, R03, R21), NSF, HFSP, AHA, DoD, March of Dimes
$11,837,417 total
Private donations:
Parker Hannifin Co.
$1,850,000 total
GRHD: indirect costs year-by-year
GRHD brought to CSU $2,349,689
GHRD was entitled to 25%
will be 20% starting 2014
$ 600,000
500,000
400,000
300,000
200,000
100,000
0
2007
2008
2009
2010
2011
2012
2013
2014
year
GRHD: awards 2009-2013
Extramural funding, grants:
NIH (R01, R15, R03, R21), NSF, HFSP, AHA, DoD, March of Dimes
$11,837,417 total
Private donations:
Parker Hannifin Co.
$1,850,000 total
From the BLUE RIDGE INSTITUTE for MEDICAL RESEARCH
BRIMR.ORG
Rank
Physiology
Name
1
VANDERBILT UNIVERSITY MED CTR
$23,437,997
2
MEDICAL COLLEGE OF WISCONSIN
$16,189,505
3
UNIV OF NORTH CAROLINA CHAPEL HILL
$15,721,507
4
UNIVERSITY OF PENNSYLVANIA
$11,771,169
5
NORTHWESTERN UNIVERSITY AT CHICAGO
$11,624,780
6
UNIVERSITY OF MICHIGAN
$10,697,104
7
UNIVERSITY OF WASHINGTON
$10,619,368
8
UNIVERSITY OF NEVADA RENO
$10,049,409
9
NEW YORK UNIVERSITY SCHOOL OF MEDICINE
$9,768,189
10
JOHNS HOPKINS UNIVERSITY
$9,461,361
11
WAKE FOREST UNIVERSITY HEALTH SCIENCES
$9,236,186
12
UNIVERSITY OF VIRGINIA
$8,312,060
13
UNIVERSITY OF MARYLAND BALTIMORE
$8,158,668
14
UNIVERSITY OF CALIFORNIA SAN FRANCISCO
$7,798,185
15
UNIVERSITY OF TENNESSEE HEALTH SCI CTR
$7,538,806
16
UNIVERSITY OF CALIFORNIA DAVIS
$7,444,029
17
UNIVERSITY OF MISSISSIPPI MEDICAL CENTER
$7,232,256
18
WEILL MEDICAL COLL OF CORNELL UNIV
$7,217,014
19
UNIVERSITY OF ARIZONA
$6,579,578
20
TEMPLE UNIV OF THE COMMONWEALTH
$6,268,841
21
OREGON HEALTH & SCIENCE UNIVERSITY
$5,950,894
22
UNIVERSITY OF FLORIDA
$5,901,429
23
UNIVERSITY OF ILLINOIS
$5,861,054
24
UNIVERSITY OF CALIFORNIA LOS ANGELES
$5,761,858
25
ALBERT EINSTEIN COLLEGE OF MEDICINE
$5,751,384
2009-2013
From the BLUE RIDGE INSTITUTE for MEDICAL RESEARCH
BRIMR.ORG
Rank
Anatomy/Cell
Biology
Name
1
ALBERT EINSTEIN COLLEGE OF MEDICINE
$20,480,861
2
BAYLOR COLLEGE OF MEDICINE
$17,498,091
3
HARVARD UNIVERSITY (MEDICAL SCHOOL)
$16,729,520
4
VANDERBILT UNIVERSITY MED CTR
$16,590,870
5
NEW YORK UNIVERSITY SCHOOL OF MEDICINE
$14,738,339
6
STANFORD UNIVERSITY
$13,622,582
7
DUKE UNIVERSITY
$13,605,292
8
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
$11,258,793
9
UNIVERSITY OF PENNSYLVANIA
$11,055,695
10
UNIVERSITY OF MICHIGAN
$10,979,313
11
UNIVERSITY OF CALIFORNIA SAN FRANCISCO
$10,620,146
12
YALE UNIVERSITY
$10,411,038
13
NORTHWESTERN UNIVERSITY AT CHICAGO
$10,302,432
14
UNIVERSITY OF CALIFORNIA DAVIS
$10,220,074
15
UT SOUTHWESTERN MEDICAL CENTER
$9,444,742
16
UNIVERSITY OF ALABAMA AT BIRMINGHAM
$9,063,212
17
UNIVERSITY OF ARIZONA
$8,508,562
18
WASHINGTON UNIVERSITY
$7,055,952
19
UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL
$7,038,407
20
UNIVERSITY OF KANSAS
$6,936,080
21
UNIVERSITY OF WASHINGTON
$6,454,280
22
UNIVERSITY OF SOUTHERN CALIFORNIA
$6,072,959
23
UNIVERSITY OF IOWA
$6,065,735
24
JOHNS HOPKINS UNIVERSITY
$5,601,913
25
UNIVERSITY OF VIRGINIA
$5,414,567
2009-2013
From the BLUE RIDGE INSTITUTE for MEDICAL RESEARCH
Rank
Name
BRIMR.ORG
Genetics
1
BAYLOR COLLEGE OF MEDICINE
$50,019,610
2
STANFORD UNIVERSITY
$27,338,571
3
WASHINGTON UNIVERSITY
$23,822,082
4
UNIV OF NORTH CAROLINA CHAPEL HILL
$23,304,731
5
UNIVERSITY OF WASHINGTON
$22,730,031
6
HARVARD UNIVERSITY (MEDICAL SCHOOL)
$16,119,740
7
UNIVERSITY OF CHICAGO
$14,703,865
8
DUKE UNIVERSITY
$14,593,805
9
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
$14,195,597
10
YALE UNIVERSITY
$12,082,529
11
WEILL MEDICAL COLL OF CORNELL UNIV
$11,412,947
12
UNIV OF MASSACHUSETTS MED SCH
WORCESTER
$11,009,262
13
COLUMBIA UNIVERSITY HEALTH SCIENCES
$10,246,903
14
EMORY UNIVERSITY
$9,771,593
15
MOUNT SINAI SCHOOL OF MEDICINE
$9,234,835
16
STATE UNIVERSITY NEW YORK STONY BROOK
$8,795,628
17
ALBERT EINSTEIN COLLEGE OF MEDICINE
$8,533,377
18
UNIVERSITY OF FLORIDA
$8,102,544
19
UNIVERSITY OF PENNSYLVANIA
$7,956,549
20
CASE WESTERN RESERVE UNIVERSITY
$7,550,572
21
JOHNS HOPKINS UNIVERSITY
$7,414,323
22
UNIVERSITY OF MINNESOTA
$7,046,247
23
UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
$7,011,350
24
UNIVERSITY OF UTAH
$6,921,971
25
UNIVERSITY OF CALIFORNIA LOS ANGELES
$6,167,443
2009-2013
GRHD publications/impact factor
Web of Science: The most comprehensive and versatile research platform available
Center
University
Establish
ed
Number of
Faculty
Number of papers published in
2009-2013
(corresponding from the center;
excluding collaborative papers)
Sum of
the
times
cited
h-index
Center for RNA
Biology
The Ohio State
University
2007
33
128
1922
22
Center for
Eukaryotic Gene
Regulation
Penn State Univ.
Huck Institutes of
the Life Sciences
2008
8
53
1252
19
Center for RNA*
Molecular Biology
CWRU
1997
10-16
79
1274
17
Center for Gene
Regulation in
Health and Disease
CSU
2008
15
69
743
17
Plant Gene
Expression Center
Univ. California
Berkeley/USDA
1987
9
55
871
17
Center for
Molecular and
Mitochondrial Med
and Genetics
University of
California, Irvine
2003
50
42
629
14
Center for
Molecular Biology
of RNA
University Calif,
Santa Cruz
1992
9
59
488
13
Sealy Center for
Molecular Medicine
University of
Texas Medical
Branch,
Galveston
2007
33
93
597
13
Center for Stem
Cell Research and
Regenerative Med.
Tulane University,
New Orleans
2000
16
39
267
10
Center for
Molecular
Microbiology
Univ Florida,
Gainesville
2000
19
20
272
7
(started in
2008)
Center
University
Established
Number of
Faculty
Center for RNA Biology
The Ohio State
University
2007
33
Center for Eukaryotic
Gene Regulation
Penn State Univ.
Huck Institutes of the
Life Sciences
2008
Center for RNA*
Molecular Biology
CWRU
Center for Gene
Regulation in Health and
Disease
Number of papers published in
2009-2013
Sum of the
times cited
h-index
128
1922
22
8
53
1252
19
1997
16
79
1274
17
CSU
2008
15
69
743
17
Plant Gene Expression
Center
Univ. California
Berkeley/USDA
1987
9
55
871
17
Center for Molecular and
Mitochondrial Med and
Genetics
University of California,
Irvine
2003
50
42
629
14
Center for Molecular
Biology of RNA
University Calif, Santa
Cruz
1992
9
59
488
13
Sealy Center for
Molecular Medicine
University of Texas
Medical Branch,
Galveston
2007
33
93
597
13
Center for Stem Cell
Research and
Regenerative Med.
Tulane University, New
Orleans
2000
16
39
267
10
Center for Catalytic
Science and Technology
University of Delaware,
Newark
2001
11
27
298
9
The Penn Center for
Molecular Discovery
Penn State,
Philadelphia
2006
16
20
151
9
Center for Molecular
Microbiology
Univ Florida,
Gainesville
2000
19
20
272
7
Center for Molecular and
Comparative
Endocrinology
University of New
Hampshire, Durham
2008
8
26
132
7
Center for Molecular
Biology and
Biotechnology
Florida Atlantic
University, Jupiter
1999
28
17
51
5
*was ranked first in the nation in NIH funding in the category of Other Basic Sciences in 2004, when compared with peer departments at other medical schools.
GRHD: present and future
BUDGET:
Indirect costs + 25K permanent budget:
Before 2014: GRHD 25%; PIs 5%
Starting 2014: GRHD 20%; PIs 10%
GRHD 2014 projected indirects: ~$100,000
Covers pilot projects, serves as bridge funding, etc…
GRHD permanent budget (provost funds): $25,000
Will continue to cover: invited speakers, printing costs,
equipment emergency repair, etc…
GRHD present and future
Apart from aggressive grant submission strategy:
Feb 5th deadline grants submitted:
3X R01s, AHA GiA, NSF (URM training grant; jointly with CWRU)
GRHD is looking for private funding to support:
Research of GRHD faculty: Pilot/innovative projects
Bridge funding
GRHD graduate students progress report seminar:
Monday 12-1 pm
GRHD distinguished/invited speakers seminar
GRHD present and future
Plans to address
Corporations:
STERIS, FISHER Scientific, AMRESCO, MPI biochemicals...
Foundations:
Ohio 3d Frontier
Mt. Sinai Health Care Foundation
The Rockefeller Foundation
Short-term goal - to get ~$2M
GRHD: web site will be re-designed
Research interests:
GRHD lab web page
Research interests:
GRHD lab web page
GRHD: web site (will use CC as a model)
Lab members
GRHD: web site
GRHD: logo will be designed by CSU art department
GRHD publicity:
Will be installed in the hallway close to
the seminar room SR255
GRHD research news appearing on this
display will be synchronized with GRHD
research news appearing on GRHD web
site
GRHD research has led to 3 start-up companies
GRHD technology transfer
GRHD research has led to 3 start-up companies:
DAPCEL, Inc
2008
(Komar, BIO, co-founder, CSO)
www.dapcel.com
Tiberian Biosciences & Pharmaceuticals, LLC
2012
(Berdis, CHM, co-founder, CSO)
http://www.tiberianbioscienceandpharma.com/
Kalafatis, LLC (name not finalized, in process of registration)
(Kalafatis, CHM, co-founder, CSO)