A new paradigm for development and distribution of medication for marginalized people Kader Abdul PhD Viola Vitalis

Diverse Need

Need Hierarchy

Disease distribution in the world Arsenicosis Malaria Cystic Fibrosis

Science put to use

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Drug based on purchasing capacity

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A failed drug cost over 600-800 million $

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Diseases do not follow the purcahsing capacity

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A protocol has been developed for designing medication for this segment of population

Vision Development and dissemination of medication for marginalized people

Approaches

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Working system on arsenicosis

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Cheaper cost, High quality, Innovative thinking

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Outsourcing activities, major inputs from available research

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Based on nutrients

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Establishing international standard

Bangladesh Arsenic Map

Arsenic induced symptoms

Necessity for complete solution for Arsenic catastrophe

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Arsenic free water

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Medication for external symptoms

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Neutralizing the internal accumulated arsenic

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Synergistic efforts to acheive all these targets

Technological solution

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Many technologies claimed that can eradicate arsenic

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Government is validating technology

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They are provided by NGOs

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Majority of the affected do not know how to use it

Affected segment

Medication available in market

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No available product in the market

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Some vitamin suppliment are provided

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Some chelating agents (selenium) are provided

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Merits and demerits of different medication

Establishing Viola Vitalis

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External and internal medication of arsenicosis

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Medication for other priority diseases

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Started operation in 2005

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Extenssive collaboration with academia

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Operation in Bangladesh

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Drug formulated in USA

Development of medication

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Compounds selected for external treatment

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Site selection in Hazigonj, 200 kilometers from capital

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Three versions of oinment formulated and tested

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Further continuation with one verssion

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Clinical proof of concepts in humans

Monitoring of clinical trial

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Three monitoring person (MP) monitored the patients on full time basis

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One coordinator select the site and the patients

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One full time doctor monitor the progress / effect of treatment

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Every parameters were documented on a regular basis

Production

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All the ingredients purchased from USA

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The ointment are formuated in USA collaboration with Allium Vitalis

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Testing different parameters

Model of operations for base and satellite clinic Satellite camp Satellite camp Satellite camp Satellite camp Base Camp Head Office Viola Vitalis Base Camp Satellite camp Satellite camp Satellite camp Satellite camp Satellite camp Satellite camp

Status of Viola Vitalis from 2005-2008

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Viola Vitalis has 5 products for diverse use

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Three satellite clinics are running

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Commercial prodcution of Ars-detox and Anti-aging capsule started on OEM basis

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Specification for Arsenicoure oinment for commercial production has been performed

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Arsenicure oinment expected to be ready in first quarter of 2009

Future Milestones

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Establishing as many satellite and base clinic as possible

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Own production plant for Viola Vitalis

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Attracting the investors who are interested to invest in social business

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Mimicing the system in other diseases of marginalized people

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Starting the same concept to develop and dessiminate the medication to other countries

The Team Viola Vitalis: Research unit and field in charge: Coordinating: Dr. M. A Salam Abdur Razzaque Awarness Programme: Monitoring Person: Pulin Behari Das Pinki Begum Chan Mia Shah Alam Business Development: M. A. Shakoor Allium Vitalis: David M Ott Cynthia Ott

Acknowledgements

• Swedish Sustainability Foundation (SSF) • Allium Vitalis, California, USA • Save The Hunger Bangladesh • Members of Viola Vitalis