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Principles of
Pharmacology
The Pathophysiologic
Basis of Drug
Therapy
Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins
Chapter 37
Pharmacology of Viral Infections
Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins
Viral Life Cycle and Pharmacologic
Intervention
• Figure 37-1
Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins
Life Cycle of HIV
• Figure 37-2
Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins
Model for HIV gp41-Mediated Fusion and
Maraviroc and Enfuvirtide (T-20) Action
• Figure 37-3
Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins
Uncoating of Influenza Virus and Effect
of Amantadine and Rimantadine
• Figure 37-4
Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins
Antiviral Nucleoside and Nucleotide
Analogues
• Figure 37-5
Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins
Mechanism of Action of Acyclovir
• Figure 37-6
Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins
Nonnucleoside DNA Polymerase and
Reverse Transcriptase Inhibitors
• Figure 37-7
Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins
Integration of HIV DNA into Cellular DNA
and Effect of Anti-HIV Integrase Inhibitor
• Figure 37-8
Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins
Anti-HIV Protease Inhibitors
• Figure 37-9
Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins
Steps in the Evolution of Ritonavir
• Figure 37-10
Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins
Structure-Based Design of Neuraminidase
Inhibitors
• Figure 37-11
Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins