Transcript Profile - TiEcon Kerala 2014

Dr. CN Ramchand
CEO,
Saksin lifesciences Pvt. Ltd
Chennai & San Francisco
Module
No:306,
3rd Floor,
Phase2,
Ticel
Bio Bio
Park,
Taramani,
Chennai
- 600
113|
Module
No:306,
3rd Floor,
Phase2,
Ticel
Park,
Taramani,
Chennai
- 600
113|
www.saksinlife.com
www.saksinlife.com
General outline
Funding and development
of biotech start-ups
My
experiences
Overview-India
& in Kerala
Module No:306, 3rd Floor, Phase2, Ticel Bio Park, Taramani, Chennai - 600 113|
www.saksinlife.com
2
Vice President & Head of
New Drug Discovery
President and
CEO
Chief Scientific
Officer
President & CEO
Director & World Wide
executive member
Advisor
Advisor
Scientific
publications
= > 150
Conferences
organized => 8
Patents => 60
Value added basic research
The Fish oil story
Curcumin based products
Nanoparticles for biological applications
4
Module No:306, 3rd Floor, Phase2, Ticel Bio Park, Taramani, Chennai - 600 113|
www.saksinlife.com
5
Major players in the country
6
Advantage India
Skilled manpower
Ecological /Cultural diversity
Large consumer base
Ancient knowledge
Agricultural base strong
English proficiency
Government
funding/Venture funding
Good IT support
Raw materials aplenty
Indian biotech in global context
Leadership vacuum
Shortage on mentors,
advisors
Publications and
Patents still less
Less number of R&D Institutes &
Universities
Research in Industry
not significant yet
Lack of awareness
about opportunities
No dialogue between
academics and industries
Less number
of startups
Academia not ready to
take risk for a venture
One mentionable point
University’s role in supporting Innovation & Entrepreneurship
Spun off from Oxford
University in 1993
Spun off from
Cavendish Laboratory at
the University of
Cambridge in 2000
Spun off from Oxford
University in 1959
Spun off from
Carnegie Mellon
University in 1994
9
Country
Period
No. Spinouts
US
19802003
4543
Canada
19622003
1100
France
19842005
1230
Netherlands
19801990s
300
Australia
19841999
97
UK
19812003
1650
10
Columbia University- >100 spin offs
11
12
Roadmap to success
Learning by example
14
Reverse pharmacology
Module No:306, 3rd Floor, Phase2, Ticel Bio Park, Taramani, Chennai - 600 113|
www.saksinlife.com
15
Conventional drug
discovery
Associated issues
Strategy
16
17
Source
Active Phytochemical
Curcumin
Application
Anti-inflammatory,
antioxidant,
antiamyloid,
antiarthritic.
Capsaicin
Long-term
analgesic,
anti-inflammary,
anti-psoriasis.
6-Gingerol
Antitumor,
anti-carcenogenic,
antiarthritic.
Epicatechin gallate
Strong antioxidant,
Anti-inflammatory,
anti-HIV.
Lycopene
Anti-ageing,
antioxidant,
antidiabetic.
Source
Active Phytochemical
Resvertrol
Caffeic acid
phenethyl ester
Diallyl sulphide
Application
Neuroprotective,
Cardioprotective
antidiabetic,
antiviral.
Anti-inflammatory,
antimitogenic,
antifungal.
Antimicrobial,
antioxidant.
Indole-3-carbinol
Anticarcinogenic,
antioxidant,
antiatherogenic.
Sulphoraphane
Inhibits H. pylori,
anticarcinogenic.
18
Development of Novel biologics at Saksin Lifesciences
Wet AMD
Module No:306, 3rd Floor, Phase2, Ticel Bio Park, Taramani, Chennai - 600 113|
www.saksinlife.com
19
Module No:306, 3rd Floor, Phase2, Ticel Bio Park, Taramani, Chennai - 600 113|
www.saksinlife.com
Age related AMD
Dry, or Atrophic or Non-neovascular
macular degeneration
Macula
Optic
disc
Wet
AMD
Fovea
centralis
Dry AMD
Wet or Exudative or Neovascular
macular degeneration
Abnormal blood vessels begin to grow
underneath the retina
Blood vessels may leak fluid or blood,
blurring or distorting central vision.
Disease causing factor
Mechanism of the novel drug
Disease causing factor Receptor in eyes
Disease complex formed
AMD
No AMD
Disease causing factor
No complex formed
Anti-VEGF Fab
DNA extraction using magnetic nanoparticles
Module No:306, 3rd Floor, Phase2, Ticel Bio Park, Taramani, Chennai - 600 113|
www.saksinlife.com
Magnetic nanoparticles
Applicable to various
biological systems
Can be performed without using
sophisticated instruments
using
DNA extraction
High yield and purity
Magnetic
nanoparticles
Easy to use for large
number of samples
Quick and robust
UK patent application
GB 2455780.
Patent application number
1067/MUM/2006
Patent application number
5676/CHE/2014
Viable
applications
Healthcare
r-DNA Products, Vaccines & Diagnostics, Monoclonal
Antibodies, Stem Cells, Tissue Specific delivery methods
Agriculture
GM crops, Micro-propagation, Bio-fertilizers & Biopesticides, Animal Improvement
Environment
Soil & Water remediation, Bio-safety & GMOs
Industry
Enzymes , Fermentation based Products & Food, Biotech
Instruments & Equipment, Bio-energy & Bio-fuel,
Bioinformatics, Bio-mining
27
28
Technology development funds
Market entry funds
Technology scale-up
/validation/de-risking funds
Technology in-licensing funds
Funds for patent protection
Expansion funds
29
Funding
Government
of
India/Kerala
Venture
capitalist
For more information visit :
http://www.venturecenter.co.
in/funding
30
Department of Scientific & Industrial Research
(DSIR)
National Research Development Corporation
(NRDC)
Major funding sources
Ministry of Micro Small Medium Enterprises
(MoMSME)
Department of Bio-Technology
(DBT)
Department of Science and Technology
(DST)
World Bank & ICICI Bank collaboration
National Innovation Foundation
(NIF)
Bill and Melinda Gates Foundation
Kerala Venture Capital Fund
Amrita Vishwa Vidhyapeetham- TBI
31
Biotechnology in India/Kerala-Thrust areas
Module No:306, 3rd Floor, Phase2, Ticel Bio Park, Taramani, Chennai - 600 113|
www.saksinlife.com
32
Advantage Kerala
Module No:306, 3rd Floor, Phase2, Ticel Bio Park, Taramani, Chennai - 600 113|
www.saksinlife.com
33
34
Prebiotics & Probiotics
FCR
enhancers
Agri-foods
Pharmaco-genomics
and Nutri-genomics
35
Regional Cancer
Center,
Thiruvananthapuram
Central Institute of
Fisheries Technology,
Ernakulam
Kerala Agricultural
University, Vellayani
Regional Research
Laboratory,
Thiruvananthapuram
Center for Water Resources
Development and Management,
Kunnamangalam, Kozhikode
Major research
institutes in
Kerala
Indian Cardamom
Research Institute,
Myladumpara, Idukki
National Research Center for Oil
Palm (Regional Center), Palode,
Thiruvananthapuram
Indian Institute of Spices
Research, Kozhikode
Central Marine Fisheries
Research Institute, Ernakulam
Central Tuber Crops
Research Institute,
Thiruvananthapuram
Central Plantation
Crops Research
Institute, Kasargod
Rubber Research
Institute of India,
Kottayam
Central Coir
Research Institute,
Kalavoor, Alappuzha
Kerala Forest Research
Institute, Peechi
36
37