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sea_bass Fugu Tilapia Rainbow_tr zebrafish Alligator Gallus Rana Human Tilapia_DA DBD NR *NR box 1 20 * 40 * 60 * 80 box 2 * 100 * 120 : ------------------------------------------------------------------------------------------------------------------------: ------------------------------------------------------------------------------------------------------------------------: ------------------------------------------------------------------------------------------------------------------------: ------------------------------------------------------------------------------------------------------------------------: ------------------------------------------------------------------------------------------------------------------------: ------------------------------------------------------------------------------------------------------------------------: ------------------------------------------------------------------------------------------------------------------------: ------------------------------------------------------------------------------------------------------------------------: MAGENHQWQGSILYNMLMSAKQTRAAPEAPETRLVDQCWGCSCGDEPGVGREGLLGGRNVALLYRCCFCGKDHPRQGSILYSMLTSAKQTYAAPKAPEATLGPCWGCSCGSDPGVGRAGLP : ------------------------------------------------------------------------------------------------------------------------- : : : : : : : : : 121 : - sea_bass Fugu Tilapia Rainbow_tr zebrafish Alligator Gallus Rana Human Tilapia_DA : : : : : : : : : : NR box 3 Poly Q stretch * 140 * 160 * 180 * 200 * 220 * 240 ----MATLEG-CRCRGASGRN-----NNSILYNILKSDS-LATAEEQQ---------------------------QQQQQQQQQQQHPQQQQTLQQLFHKT--SSTAAPASLQELR---QQ ----MATLEG-CRCRGSGGRNT----NNSILYSILKSDT-LATTEEQQPK-------------------------QQQQQQQQQQQQQQQQQSLQHLLFKSPPASTAAPASLQELR---QQ ----MATLEG-CRCRGASGRNNNSSSSSSILYSILKSDDRLVTAEEQQ-------------------------------------QHP-QQHTLQHLFQKP--PSSSASASLQEVR---QQ ----MATREG-CHCPGTGGQNN----NNSILYHILKNDR-LTTTEEQQ------------------------------------TITKPQQHQQHRWHRVSSCSSSSSSSSRLELRQ--QQ ----MAYFDSGCHCSSERRQN-------SILYSILKNDS--------------------------------------------------QSAQLG----------NQPRAPRLAVS---MR ------CVGRGRCCAGGR-RQG------SILYHILRS---------------------------------------------------EEQPR-----------GSGPGCSCG------AR ----MACLERCHCCADGR-RHG------SILYSILKS---------------------------------------------------HDQAAE----------GPGPRRGQA------GR ----MACLDKCHCAVDNR-RHG------SILYNILKN---------------------------------------------------EEHKDS----------HNSSKISKEDHSRLYGQ GGRPVALLYRCCFCGEDHPRQG------SILYSLLTSSKQTHVAPAAPEARPGGAWWDRSYFAQRPGGKEALPGGRATALLYRCCFCGEDHPQQGSTLYCVPTSTNQAQAAPEERPRAPWW --------MSCCECKVTQDTGQ-----GSILYSILNRG--------------------------------------------------ALCPQAR----------ADTTAAH--------R : 78 : 83 : 73 : 73 : 47 : 40 : 43 : 49 : 236 : 40 sea_bass Fugu Tilapia Rainbow_tr zebrafish Alligator Gallus Rana Human Tilapia_DA : : : : : : : : : : LBD * 260 * 280 * 300 * 320 * 340 * 360 TCSCGSTRRRGILRFPQVTCKAASAVLVKTLRFVKNVPCFRELPEDDQLMLIRSGWAPLLVLGLAQDRVDFETTETVEPSMLQRILTG---------------LPDRQSEVPAGQSRGAAG ACSCGSTRRRGVLRSPQVTCKAASAVLVKTLRFVKNVPCFRELPEDDQLALIRSGWAPLLVLGLAQDRVDFETTETVEPSMLQRILTG---------------SPEGRNQALGCHSRTAAG ACSCGSTRRRGVLRSPQVTCKAASAVLVKTLRFVKNVPCFRELPEDDQLVLIRSGWAPLLVLGLAQDRVDFETTETVEPSMLQRILTG---------------CPDRQSEAVGGQNRGAPG ACSCGSSRRRGSLRSPQVTCKAASAVLVKTLRFVKNVPCFRELPEDDQLLLVRNCWAPLLVLGFAQDRVDFEITETAEPSMLQRILTGGSGSQS--------GLTDRQGEPLLEQSTETSG ACASGS-KRKVSLRSPQTTCKAASAVLVKTLKFVKNVPCFRELPADDKHTLVRSGWAPLLVLGMAQDRIDFETSETQEPSMLQRILTS---------------QQDKQD-----NQSHNGG GRGRGR-SRAAAGGER----AAAAAVLVKTLRFVKGVPCFQQLPLAEQLVLVRAAWAPLLVLGLAQDGVALPAHEAAQPSMLQRILTAR------------------------PPP----GCSCGS-QRRVALKSPQVVCKAASAVLVKTLRFVQNVPCFQELPLDEQLVLVRSCWAPLLVLGLAQERVHLETVESAEPSMLQRILTTRRLGE------------------HAPAPGRQHP GCSCGS-QKKVTLKSPQVTCKAASAVLVKTLRFVKSVPCFQELPLEDQLLLVRSCWAPLLVLGLAQDKVNFETVETSEPSMLQRILTNSQGGENKLHHEHSEQDFLFGNSQHQQHNKLSQL DTSSGA-LRPVALKSPQVVCEAASAGLLKTLRFVKYLPCFQVLPLDQQLVLVRNCWASLLMLELAQDRLQFETVEVSEPSMLQKILTTRRRETG----GNEPLPVPTLQHHLAPPAEARKV CCSCASMRKLVAIRAPQSVIRAACEVLLKTFRFVKNVPCFRGLPADDQLRLVRNSWAPLLLLGLVQDSVDFDTVETQKPSLLHEILTH-----------------DANRRERTAGAAQHPG : : : : : : : : : : sea_bass Fugu Tilapia Rainbow_tr zebrafish Alligator Gallus Rana Human Tilapia_DA : : : : : : : : : : * 380 * 400 * 420 * 440 * 460 * AF-2 480 VSVVDIEAIKAFLKKCWSVDISTKEYAYLKGAVLFNPDVEGLRCLHYIQSLRREAHQALNEHVRLIHREDTTRFAKLLIALSMLRAINPLVVAQLFFRPVIGAVNIEEVLMEMFYGKVSVLDIEAIKAFLKKCWSVDISTKEYAYLKGAVLFNPDVEGLRCLHYIQSLRREAHQALNEHVRLIHREDTTRFAKLLIALSMLRAIRPPVVAQLFLKPVIGTVNIEEVLMEMFYGKVSVVDIEAIKAFLKKCWSVDISTKEYAYLKGAVLFNPDLEGLRCLHYIQSLRREAHQALNEHVRLIHREDTTRFAKLLIALSMLRAISPPVVAQLFFRPVIGTVNIEEVLMEMFYGKVSLADIRASKRSLKKCWALDISTKEYAYIKGAVLFNSDLPGLRYLHYIQS-------------------------------------------------------------------VALTDVQGIKMFLRKCWGLDISTKEYAYLKGAILFNPDVAGLQCQHYIQALQSEANQALNEYVKMIHRGDSARFAKLFLALSMLRSINANVVAGLFFKPVIGAVNMEELLLEMFYGKPPAADLQALHGVLAKCWSLDIGPKEYAYLKGAVLFNPDLPGLQCTQYIQGLQREAQQALNEHVRLIHRGDQARFAKLNIALSLLRSINANVIAELFFRPIIGTVNMDDMLLEMLCAKL PSAGEIQAIKGFLAKCWSLDISTKEYAYLKGTVLFNPDLPGLQCTQYIEGLQKEAQEALNEHVRLIHRGDQARFAKLNVVLSLLRSINANVIAELFFRPIIGSVNMDDMLLEMLCAKL PSATEIRWIKEFLEKCWSLAISTKEYAYLKGIVLFNPGLPGLHCAQYIQGLQQEAHQALNEHVKMIQRWDNARFTKLIIVLSLLRSINANAISELFFRPIIGTVNMDDMLLEMLGAKI PSASQVQAIKCFLSKCWSLNISTKEYAYLKGTVLFNPDVPGLQCVKYIQGLQWGTQQILSEHTRMTHQGPHDRFIELNSTLFLLRFINANVIAELFFRPIIGTVSMDDMMLEMLCTKI VPLCDVQSIQMFLVKCRGLTITVKEHAFLKGAILFTP-VPELECQEYIHALQREAERALYEHVGTVYRGNASRSGKLRVVLSTLRAVDTEAVAGLFLRPVTGTSSIDEHVLAMFCER- : : : : : : : : : : 301 306 296 236 264 245 263 287 470 260 184 189 179 186 147 127 145 169 352 144