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Principles of
Pharmacology
The Pathophysiologic
Basis of Drug
Therapy
Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins
Chapter 22
Pharmacology of Hemostasis
and Thrombosis
Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins
Sequence of Events in Hemostasis
• Figure 22-1
Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins
Platelet Adhesion and Aggregation
• Figure 22-2
Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins
Platelet Activation
• Figure 22-3
Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins
Platelet Activation by Thromboxane A2
• Figure 22-4
Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins
Platelet Activation by ADP and Thrombin
• Figure 22-5
Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins
Coagulation Cascade
• Figure 22-6
Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins
Coagulation Factor Activation on
Phospholipid Surfaces
• Figure 22-7
Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins
Central Role of Thrombin in the
Coagulation Cascade
• Figure 22-8
Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins
Antithrombin III Action
• Figure 22-9
Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins
The Fibrinolytic System
• Figure 22-10
Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins
Virchow’s Triad
• Figure 22-11
Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins
Overview of Prostaglandin Synthesis
• Figure 22-12
Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins
Mechanism of Action of Antiplatelet
Agents
• Figure 22-13
Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins
Mechanism of Action of Warfarin
• Figure 22-14
Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins
Differential Effects of Unfractionated Heparin, Low-MolecularWeight Heparins, Selective Factor Xa Inhibitors, and Direct
Thrombin Inhibitors on Coagulation Factor Inactivation
• Figure 22-15
Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins