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DIOSED-C
tablets
With vitamin C
Medical Background
Veins of Lower Limb:
These are divided
into 3 groups:
1. Deep Veins
2. Superficial Veins
3. Perforators
Medical Background
1. Deep Veins:
• Linear Beneath the deep fascia
accompanying Arteries.
• These veins drain the structures deep to
the deep fascia and receive blood from
the superficial veins through the
perforating veins.
• They include Planter, Ant.Tibial, Post.Tibial,
Popliteal and Femoral veins.
Medical Background
2. Superficial Veins:
• Lie Superficial to the deep fascia (i.e. in
the S.C tissues).
•
Drain the skin and S.C tissues of L.L
except the skin of lower 1/3 of leg (ulcer
bearing area) which drained by Ankle
perforators which pierce the deep fascia
to end directly in the deep veins.
Medical Background
Superficial Veins include:
Long (Great) Saphenous vein:
•
•
•
Begins on the dorsum of the foot as a continuation of
medial end of dorsal venous arch of foot.
It ascends in front of medial malleolus,medial aspect of leg.
It ends by piercing the cribiform fascia to join the femoral
vein at the sepheno femoral junction.(4 cm below & lateral
to the tubercle).
Communicators:
•
The long and the short Saphenous veins are connected to
each other many variable unfixed communicators.
Medical Background
Short (Lesser) Saphenous vein:
• Begin on the dorsum of the foot as a continuation
of lateral of dorsal venous arch of the foot.
• It passes below & behind the lateral malleolus to
reach the back of leg to ascend the center of the
calf.
• Commonly it ends in the popliteal fossa by joining
the popliteal vein (Sapheno-popliteal junction).
Medical Background
3.Perforators:
These veins perforate the deep fascia to connect the
deep & the superficial systems.
This may be:
1. Indirect Perforators:
Pass from: superficial veins
muscular veins
deep veins.
2. Direct Perforators:
Pass from superficial veins
deep veins.
Diosed-C :
Usages:
• Varicose veins.
•
Dysfunctional uterine bleeding.
•
Hemorrhoid.
DIOSED-C:
Composition:
• Diosmin is of plant origin, flavonoid fraction.
• Diosmin is a 7-rutinoside 3,5,7-trhydroxy-4methoxyflavone.
• Flavonoid are known to reduce reactive oxygen
radicals released by (PMNs)-polymorph-nuclear
nutrophils in vitro.
• Rutin is a greenish yellow micro crystalline powder
obtained from black wheat “fago pyrum esculentum”.
• Diosmin used similar to rutin in the treatment of venous
disorders.
DIOSED-C:
Pharmacokinetics:
• Diosmin is rapidly absorbed after oral administration.
• Diosmin has rapid onset & long duration of action.
• Diosmin has minimal transplacental & breast milk
passage.
• Diosmin has long plasma elimination half-life ranging
from 26 to 43 hours.
• Diosmin is eliminated as minor metabolites in urine
mainly as Glucoronic acid conjugate.
DIOSED-C:
Mechanism of action:
1. Diosmin has vaso constrictive effect by local
inhibition of COMT (Catechol-omethyltransferase) enzyme activity.
2. Diosmin enhances the sympathetic activity
by increasing nor-adrenaline levels in the
synaptic clefts of the vascular wall.
DIOSED-C:
Mechanism of action:
3.Diosmin reduces the micro vascular high
permeability.
4.It Improves cutaneous micro-circulation
as it:
• Normalizes capillary resistance and
permeability.
• Inhibits the release of the main
pericapillary mediators of inflammation.
These described effects on skin
microcirculation contribute to a better
peri-ulcer nutrition.
DIOSED-C:
Mechanism of action:
5.Diosmin has the ability to scavenge active
oxygen radicals.
6.Diosmin inhibits (PGE2) synthesis,(PGF2α)
and thromboxane B2.
7.Diosmin decrease the R.B.C aggregation
which can induce a decrease of blood
flow resistance and a reduction in stasis.
8.Diosmin reduces the protein concentration
in the intestinal tissues.
Diosmin:
• significantly increases venous tone by improving
venous wall nor-adrenaline activity.
• Veins recover 70% of their maximal contractibility with
Diosmin.
• Whereas it drops to 40% in controls.
70%
60%
50%
% of maximal
40%
venous
30%
contractability
20%
10%
0%
70%
60%
57%
40%
Diosmin
Troxerutin
Rutin
Venous contractability
Control
Diosmin:
• Diosmin significantly improves the leg ulcer
healing process.
% of patients
100%
80%
60%
40%
20%
0%
No change
Improvement or
resolution
Placebo
Diosmin
Diosed-C
• Diosed-C shows an effective and rapid relief of signs
and symptoms in acute and chronic Hemorrhoids.
• Diosed-C is highly effective as a basic treatment of
Hemorrhoids even when complicated.
% of patients improvement
in 15 days
Excellent
Good
120%
100%
80%
60%
40%
20%
0%
Anal fissure
Thrombosis
Anal inflammation
Diosed-C
• Diosed-C is an effective treatment for CVI from early
phase to its complications.
• Diosed-C has an excellent efficacy on the
disappearance of all CVI symptoms.
80
70
60
50
40
30
20
10
0
Diosmin
Placebo
Cram
p
s
Pare
sthe
sis
Pain
Leg
Heav
in
ess
Diosed-C
• Diosed-C is the
unique
combination that
allows healthy
venous tone.
In
Gynecology
Phlebology
Proctology