Transcript Drugs and pregnancy project

Congenital anomalies 1993–2010
Statistical Report 1/2013 in figures
Annukka Ritvanen
Seija Sirkiä
17.7.2015
Statistical Report 1/2013 / Annukka Ritvanen and Seija Sirkiä / Malformation Register / THL
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Congenital anomalies 1993-2010
• In 1993–2010, the prevalence of births with major congenital
anomalies remained rather stable.
• Annually major anomalies were detected on average in 3,5 per
cent of births or in slightly more than 2000 births.
• The major periodic variations in the prevalence are associated
with the reforms in the Malformation Register activities. The
smaller random variation is due to the rarity of congenital
anomalies.
• There were no significant differences between the data of the
various malformation types for 2010 and data for previous years.
• During the follow-up period 1993–2010 an average of about 250
pregnancies were terminated annually because of major foetal
structural anomalies and chromosomal defects. The number of
selective terminations of pregnancy has slowly increased, being
about 340 in 2010.
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Statistical Report 1/2013 / Annukka Ritvanen and Seija Sirkiä / Malformation Register / THL
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Miia Artama, projektipäällikkö, Stakes
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Figure 1. Prevalence of cases with major
congenital anomalies (1/10 000 births) in 1993–2010.
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Figure 2. Proportion (%) of selective terminations of
pregnancy of all cases with major anomalies in
1993–2010.
[Selective terminations of pregnancy / (births + selective terminations of
pregnancy)].
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Statistical Report 1/2013 / Annukka Ritvanen and Seija Sirkiä / Malformation Register / THL
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Figure 3. Prevalence of selective terminations
of pregnancy (1/10 000 births) in 1993–2010.
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Figure 4. Prevalence of cases with major congenital
anomalies (1/10 000 births) in the areas of special
responsibility of the university hospitals in 1993–2010.
The areas of special responsibility of the university central hospitals
HUCH =Helsinki and TUCH =Turku and university hospitals
TAUH =Tampere, KUH =Kuopio and OUH =Oulu.
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Statistical Report 1/2013 / Annukka Ritvanen and Seija Sirkiä / Malformation Register / THL
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Artama, projektipäällikkö, Stakes
Figure 5. Proportion (%) Miiaof
selective terminations of7
pregnancy performed for foetal abnormalities of all cases
with major congenital anomalies in the areas of special
responsibility of the university hospitals in 1993–2010.
[Selective terminations of pregnancy / (births + selective terminations of
pregnancy)].
The areas of responsibility of the university central hospitals HUCH =Helsinki
and TUCH =Turku and university hospitals TAUH =Tampere, KUH =Kuopio and
OUH =Oulu.
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Statistical Report 1/2013 / Annukka Ritvanen and Seija Sirkiä / Malformation Register / THL
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Miia Artama, projektipäällikkö, Stakes
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Figure 6. Prevalence for anencephaly and
spina bifida (1/10 000 births) in 1969–2010.
Anencephaly
Spina bifida
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Figure 7. Proportion (%) of selective terminations of
pregnancy of all pregnancies with anencephaly and
spina bifida in 1981–2010. [Selective terminations of pregnancy /
(births + selective terminations of pregnancy)].
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Statistical Report 1/2013 / Annukka Ritvanen and Seija Sirkiä / Malformation Register / THL
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Figure 8. Prevalence for Down syndrome
(trisomy 21)(1/10 000 births) in 1993–2010.
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Figure 9. Prevalence for Down syndrome (trisomy 21)
by maternal age groups (1/10 000 births) in 1993–2010.
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Statistical Report 1/2013 / Annukka Ritvanen and Seija Sirkiä / Malformation Register / THL
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Figure 10. Prevalence for Down syndrome (trisomy 21)
(1/10 000 births) in 1991–2010; standardised and nonstandardised by maternal age groups.
1.
1. Births and selective terminations
of pregnancy
2. Births
3.
3. Selective terminations of
pregnancy
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Statistical Report 1/2013 / Annukka Ritvanen and Seija Sirkiä / Malformation Register / THL
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Miia Artama, projektipäällikkö, Stakes
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Figure 11. Proportion (%) of selective terminations of
pregnancy of all pregnancies with Down syndrome
(trisomy 21) in 1993–2010.
[Selective terminations of pregnancy / (births + selective terminations of
pregnancy)].
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Statistical Report 1/2013 / Annukka Ritvanen and Seija Sirkiä / Malformation Register / THL
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Figure 12. Proportion (%) of selective terminations of
pregnancy of all pregnancies with Down syndrome
(trisomy 21) in 1993–2010 by maternal age groups.
[Selective terminations of pregnancy / (births + selective terminations of
pregnancy)].
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Statistical Report 1/2013 / Annukka Ritvanen and Seija Sirkiä / Malformation Register / THL
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Figure 13. Prevalence for orofacial clefts in
births and in births and selective terminations
of pregnancy (1/10 000 births) in 1974–2010.
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Statistical Report 1/2013 / Annukka Ritvanen and Seija Sirkiä / Malformation Register / THL
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Figure 14. Total prevalence (1/10 000 births) for cleft
palate (CP) and cleft lip with or without cleft palate
(CLP) in 1974–2010.
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Links
• Congenital anomalies 1993−2010
Statistical Report 1/2013:
– www.thl.fi/fi/statistics/congenitalmalformations
• www.thl.fi
• www.icbdsr.org
• www.eurocat-network.eu
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