Transcript Slide 1

Children’s Cancer and Leukaemia Group
‘Caring for children – curing their cancer’
Tissue Bank: Introduction
Sue Ablett
6/7/2011
Background
• Proposal to move to centralised Tissue Bank
subject to lengthy review process
• End 2010: decision by CRUK to support
centralised CCLG Tissue Bank
• Bank to be located at University of Newcastle
upon Tyne
• Central coordination of Bank and associated
biological studies: CCLG, Leicester
CRUK position
• CCLG Tissue Bank - valuable and unique.
• The decision to fund the Bank is contrary to
current CRUK policy of not funding standalone tissue banks.
• Need for real progress over next 3 years.
• Responsibility for success lies with Leicester
and Newcastle teams, and banking centres.
• CRUK role is one of facilitator, and funder.
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Challenges
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Establish mechanism for joint working
Ensure good communication with all parties
Agree success criteria
Linked clinical data
Progress the move to centralisation in a
reasonable timeframe
• Continued delivery on success criteria
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Success criteria
• Increased rate of tissue banking
- addressing under yielding centres
• Improved numbers in and out of Bank
• Improved quality control
• Raised profile for the Bank (ISBER, CCB)
• Increase in applications for use of samples
• Reduced timescale for sample release
• Increased number of publications
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Success criteria continued
• Impact of biological studies on clinical
practice
• Retrospective sample collections – complete
transfer (12 months)
• In parallel, instigate move of prospective
samples (batched by centre)
• Consider position of Constitutional DNA
(currently banked in Leeds)
• Secure longer term funding
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Tissue Bank: Status
• As of December 2010:
- 7,165 samples registered/available for
release (~5,000 frozen, ~2,000 paraffin)
- ~1000 new samples registered p.a.
- ~1700 DNA samples banked, of which
~40% have corresponding tumour stored
- Currently 49 biological studies ongoing,
using banked samples
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Progress to date
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CRUK facilitated meeting 1.2.2011
Joint monthly operational team ‘meetings’
Reciprocal team visits
Substantial protocol amendment
Expanded range of SOPs
Schedule for moving samples (retrospective
collections, then prospective)
• Centre visits to facilitate
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Progress to date contd
• Publicity (via CCLG, CCB, CRUK
Newsletters)
• Redesign of CCLG website – higher profile
and easier access to Tissue Bank
• Tissue Bank Education Day – 6th July 2011
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Tissue Bank Education
Day
• Jointly organised
Children’s Cancer and Leukaemia Group
‘Caring for children – curing their cancer’
CCLG TISSUE BANK EDUCATION DAY
FOCUS ON CENTRAL BANKING
Wednesday 6th July 2011 · 9am – 4pm (Coffee & Lunch provided)
Percy Building Lecture Theatre , G05 · Newcastle University
Topics to be covered include
• Central banking process
• Transfer of registered tissue samples to the Biobank
• Update on HTA and consent of human tissue
• Demonstration of slide digitization of paraffin embedded tissue
• Tissue samples used in Biological studies linked to Clinical Trials
• CCLG Tissue Bank samples used in Biological Studies
• Q&A session – central banking process
Supported by
CCLG Tissue Bank is an official member of
For further information contact:
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Gita Mistry (Leicester)
CCLG Tissue Bank Manager
Email: [email protected]
Tel: 0116 249 4476
Zoe Davison (Newcastle)
CCLG Tissue Bank Project Manager
Email: [email protected]
Tel : 0191 246 4442
• 3 representatives of
all centres to be
invited
• Annual event ?
Aims of Education Meeting
• Information – background and challenges
• Context – where do the samples fit in overall
process?
• Benefits from banking of samples?
• Practical issues in relation to sample transfer
• Networking – ‘faces to names’
• Improving communication
Organogram
CCLG EXECUTIVE
(Chairman: Mark Gaze)
CANCER RESEARCH UK
(Funders)
CCLG BIOLOGICAL STUDIES
STEERING GROUP
(Chair : Keith Brown)
MANAGEMENT & COORDINATION OF
TISSUE BANK & BIOLOGICAL STUDIES
(Leicester Team)
COORDINATION OF SPECIMEN
STORAGE AND RELEASE FOR TISSUE
BANK
(Newcastle Team)
CCLG EXECUTIVE DIRECTOR
Sue Ablett
DIRECTOR OF NEWCASTLE
BIOMEDICINE BIOBANK AND
NICR
Andy Hall
BIOLOGICAL STUDIES
ADMINISTRATOR
Sue Thornton
TISSUE BANK MANAGER
& BIOLOGICAL STUDIES
COORDINATOR
Gita Mistry
BIOBANK QUALITY ASSURANCE
MANAGER
Carol Sandercock
TISSUE BANK DATA
COORDINATOR
Helen Middleton
BIOBANK COORDINATOR
Zoe Davison
TISSUE BANK SUPPORT &
EDUCATION
Gail Jenner
BIOBANK TECHNICIAN
Alison Page
Children’s Cancer and Leukaemia Group
‘Caring for children – curing their cancer’
Supported by
Tel: 0116 249 4460
Fax: 0116 254 9504
CCLG Central Tissue Bank
(Tissue Storage Location)
Newcastle Biomedicine Biobank
Faculty of Medical Sciences
4th Floor Leech Building
Newcastle Upon Tyne, NE2 4HH
Tel: 01912464442
Fax: 0191 246 4301
website: www.cclg.org.uk
website: www.ncl.ac.uk/nbb/
CCLG Coordinating Centre
(Tissue Bank Coordination)
3rd Floor, Hearts of Oak House
9 Princess Road West
Leicester, LE1 6TH