Transcript Sample Transfer - Children's Cancer and Leukaemia Group

Children’s Cancer and Leukaemia Group
‘Caring for children – curing their cancer’
Sample Transfer
Dr Zoe Davison
Central Bank, Newcastle
6/ 7/ 2011
Transferring Samples into the Central
Bank
Children’s Cancer and Leukaemia Group
‘Caring for children – curing their cancer’
Phases of Transfer
• Phase I: Centre visits
• Phase II: Transfer of historical collections
• Phase III: Transfer of prospective samples
Phase I
• Small team of Andy Hall, Gail Jenner and Zoe Davison visit
centres to introduce ourselves with banking personnel
• Talk through the logistics of transferring samples and work
out a rough time frame for this
• 4 site visits and 1 teleconference completed to date
• 4 more visits scheduled and plan to complete this stage by
the end of the year
Phase I
Key points from recent visits:
• FFPE tissue
• Batching of samples for despatch
• Anonymisation
• Transit time
• Consent
• Samples embedded in clinical trials
Phase I: Desired outcomes
• Rough numbers of samples
• Size and shape of the vials
• Whether samples will be
anonymised prior to dispatch to
the bank
• A rough time scale for dispatch
of the historical samples
Phase II
Send
cryoboxes to
centre
Contact the
appropriate
person at centre
and arrange a
convenient time
for collection
Samples
collected by
PDP and
transported
same day
Data entered
into Matrix
Gemini LIMS
Unpacked &
transferred
to portable 80
Barcoded,
scanned &
stored away in
a monitored
freezer
Phase II: Courier
• Using PDP – The Clinical Trials &
Healthcare Specialists Courier
• Transported same day where possible
• All packaging and dry ice will be
provided
• Include temperature monitoring device
• The cost of the courier service will be
paid by the Central Biobank
Phase II
• Newcastle frozen samples
transferred in two batches
- first batch transferred using
portable -80 freezer
• Carol putting final touches to
MTAs and SLAs so we can start
transfers from Birmingham,
Glasgow and Liverpool
Phase III
• Once we have transferred the historical
collection we will arrange a rota
• Send 2D bar-coded tubes
• Normally be 6 monthly
• Registration will still be done at Leicester
• Payment will be made every 6 months upon
receipt at the Central Bank
Phase III
• Nunc
Bank-it 2d barcoded
tubes
• Lock into the 96 well or 48
well rack
• 0.5 ml and 2 ml sizes
• Write CCLG number on side
• Batched to central bank on 6
monthly basis and scanned into
database
Consent Auditing
• Our recent HTA audit highlighted the area of
consent
• Impractical to keep a copy of all consent forms
• Plan a 3 yearly informal audit of consent forms
at centres
• Also use this time to chat about any issues
that have been identified
Children’s Cancer and Leukaemia Group
‘Caring for children – curing their cancer’
Supported by
Tel: 0116 249 4460
Fax: 0116 254 9504
CCLG Central Tissue Bank
(Tissue Storage Location)
Newcastle Biomedicine Biobank
Faculty of Medical Sciences
4th Floor Leech Building
Newcastle Upon Tyne, NE2 4HH
Tel: 01912464442
Fax: 0191 246 4301
website: www.cclg.org.uk
website: www.ncl.ac.uk/nbb/
CCLG Coordinating Centre
(Tissue Bank Coordination)
3rd Floor, Hearts of Oak House
9 Princess Road West
Leicester, LE1 6TH