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AADR PRESENTATION TO ADEA ‘NEW DEANS’ 1 “A Critical Role for AADR in Shaping the Future of Academic Dental and Craniofacial Research” Nov 10th, 2012 Rena D’Souza, AADR President Christopher Fox, AADR Executive Director Topics…… How Dentistry Evolved - The Discoveries of Dentists that Shaped Health Care Challenges and Opportunities for Dentistry - Can we Shape the Future? Translational and Clinical Research - What ? Why ? How ? Signature Initiatives from NIDCR/NIH What is AADR’s Role? The Beginnings…. Barbers and Blacksmiths Past 150 yrs Horace Wells William Morton G.V. Black Edward Angle Truman Brophy Willoughby Miller (1890)* -Bacterial basis for Oral Diseases -Disease Prevention (JADA: 140, 2009) The Scientific Evolution of Dentistry William J. Gies and the 1926 Carnegie Foundation Report on Dental Education Dental Schools Incorporated as part of Health Sciences/Medical Centers and Universities Development of Dental Scientific Journals and Publications in Medical and other Scientific Journals The role of immigrant dental scientists from Europe Opening of National Institute of Dental Research in 1948 The Challenges are Great Too !!! Those closest to the clinical challenges will generate to translate discoveries theHow most pertinent and relevant questions. about the DOC complex into better treatment and prevention of Hence a robust body of dental and craniofacial research findings diseases and disorders while pushing the should be emanating from our dental institutions frontiers of basic science yet further ? Our Needs Are Great!!!! Challenges and Opportunities for Dentistry 8 Research is becoming more difficult to support Grants are difficult to obtain Higher % of NIDCR Funding outside dental schools New schools with minimal infrastructure for research Lack of formal training in clinical research methods Need for better diagnostics, point-of-care therapeutics Several studies available for translation Increase in evidence-based instruction Back to the Future….. NIDCR, 2012 Personalized Medicine Predictive, Preventive, Precision Care Personalized medicine in the sense of the ‘right treatment for the right patient at the right time”has been practiced for millennia (Steele, F. Pers. Med. 2009.6,1-5) Provides the ability to classify individuals into sub populations based on their susceptibility to a disease or response to a specific treatment NIDCR 2012 NIDCR 2012 NCRR Supports the Continuum of Biomedical Research Definition of Translational Research Translational research fosters the multidirectional integration of basic research, patient-oriented research, and population-based research, with the long-term aim of improving the health of the public (Rubio et al., 2010) NIH definitions of clinical research Clinical Research. NIH defines human clinical research as (1) Patient-oriented research. Research conducted with human subjects (or on material of human origin) for which an investigator (or colleague) directly interacts with human subjects. Patient-oriented research includes: (a) mechanisms of human disease, (b) therapeutic interventions, (c) clinical trials, and (d) development of new technologies. (2) Epidemiologic and behavioral studies. (3) Outcomes research and health services research. NIDCR, 2012 Clinical Research Traditional epidemiology studies Mechanistic studies using patient samples Other studies, such as cohort studies following subjects to determine outcomes of treatment(s). An example would be a study following individuals with diabetes and dental implants to determine if poor glucose control is associated with shorter implant survival. NIDCR, 2012 Educational and training opportunities NIH CTSA program Many translational training programs developed at CTSA institutions, many focused on training clinicians, but others focused on training basic scientists CTSA institutions working to develop common training standards and best practices--core competencies under development CTSA consortium creating a repository of programs (on-line and traditional) available at institutions around the country—National CTSA Educational Resource Program 2010-Building a National CTSA Consortium 55 CTSA sites in 28 states and the District of Columbia WA MT ME ND OR VT MN ID NH WI SD NY MI WY NV OH IL UT MD IN CO WV KS MO OK VA NC AR SC NM MS AK TX DE NJ KY TN AZ RI PA IA NE CA MA AL GA LA FL HI = IDeA-Eligible States = CTSA States = IDeA-Eligible State and CTSA Member PR National Dental Practice- Based Research Network : NDPRN NIDCR, 2012 NIDCR, 2012 NIDCR 2012 How can AADR Help? Organize Information Transfer Sessions and Training Workshops at AADR Annual Sessions?? Clinical Research Methodology ? Research Mentoring Teams for Junior Faculty? Practice-Based Research Network Forums ? Meetings with Program Officers from Funding Agencies ? Year-long AADR- Sponsored Activities ??? Visits of President and Board Members to Schools ? Activation of Local Chapters/Sections? Dean Participation??? IADR/AADR Global HQ, Alexandria, VA Rena D’Souza, AADR President, [email protected] Christopher Fox, AADR Executive Director, [email protected]