Research in the School of Dentistry

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School of Dentistry 1888

First class enrolled 3 year program 22 students 4 faculty .

Dr. Edith White followed the gold rush to the Yukon

School Statistics

• •

Student body

– 98 DDS students/class – 10 PASS students/2 classes – 24 BS dental hygiene students/class – 10 MS dental hygiene students/class – 9 dental therapy students/class – 92 residents in 8 advanced education programs

Faculty

– 116 full-time – 181 adjunct •

Professional and support staff

– 232 total

Clinical services

Moos Tower –

open to the public

377 clinical operatories 95,514 patient visits per year Outreach sites: 15,000 patient visits Northpoint Health & Wellness Cntr Center (N. Mpls) CUHCC (S. Mpls) Walker Dental Clinic (S. Mpls) Hibbing Willmar Howard, South Dakota Mobile Dental Unit Continuing Dental Education: 154 courses per year 7,349 practitioners

Research Training

Graduate Program in Oral Biology MinnCResT (NIDCR T32)

Positions: 11 post-doc 7 pre-doc

18

Ph.D. oral biology - 13 Other Ph.D. – 5

Summer Research Opportunities

Graduate Program in Oral Biology 40

th

Anniversary in 2009

14 grad students 32 Faculty

School of Dentistry Veterinary Medicine Department of Medicine, Medical School. Department of Microbiology Department of Neuroscience, School of Medicine Department of Pediatrics and Department of Genetics, Cell Biology and Development Department of Pharmaceutics, College of Pharmacy

Director: Mark Herzberg T32DE007288-14 Neuroscience Microbiology and Immunology Cancer Biology Developmental Biology, Molecular Genetics, and Stem Cells Clinical Research . Translational Genetics and Communications Disorders Genomics, Proteomics, Structural Biology, and Computational Biology Nanotechnology, Materials Sciences, and Tissue Engineering

Summer Research

Director: Joel Rudney, Asst. Dean Res.

DDS (DH) students

20 students / year 10 week full-time program $600,000 fundraising campaign to stabilize funding

Research Funding

NIH institutes: NIDCR NIDA NCI NIAID NIGMS NINDS ORWH NSF HRSA/MN Corporate: 3M ORMCO Dentscare Amgen ARRA funding: R21 R01 supplement NSF subcontr.

GO grant IHI/SON

Funding Sources FY09

NIDCR Other NIH Institutes Subcontracts Non-federal

9% 32%

.

17% 42%

Funding Increase Jun-Nov 2009

$3,000,000 $2,500,000 June $ 4.5M

November $ 6.3M

ARRA: $862,265 $2,000,000 $1,500,000 $1,000,000 $500,000 $0 NIDCR Other NIH Inst Subcontracts Non-federal

21 Funded SOD investigators

Research Areas

Bone Biology

Neuroscience, Pain

Microbiology,

Virology

Salivary Proteins Cell Biology Biomaterials

Dental Materials

Imaging Immunology

Periodontal and Systemic Disease

Temporomandibular joint disease Orthodontics Endodontics Dental Implants Oral Surgery Oral Cancer Developmental Biology Public Health, Preventive Care

Director: Louis Mansky

Investigators: School of Dentistry - 5 School of Medicine - 15 College of Pharmacy - 3 School of Public Health - 2 College of Veterinary Science - 5 Mayo Clinic - 13

Bacteriophage phi29

1966:

Bacteriophage phi29 is identified by

Bernard Reilly and Dwight Anderson

from soil sample obtained on St. Paul Campus

2009:

R01DE003606-39 Morphogenesis of bacteriophage phi29

Shelley Grimes

.

Director: Alex Siu-Lun Fok Works closely with manufacturers to develop and test new dental products and materials in the areas of biomaterials, biomechanics and nano technology. 3M support since 1991 .

Virtual Dental Patient:

interactive 3D computer rendition of a dental patient.

Artificial Mouth:

replicates the effects of a year of chewing in one day (“chews” 300,000 per day) Exhibited in Smithsonian Inst.

Shape Optimization of Dental Restorations

An interdisciplinary project involving engineers and dental scientists. 92% of fractured teeth have been previously restored Shape optimization based on finite element analysis and biological adaptive growth process led to significant reduction in the stress levels at the tooth –restoration interface.

Conventional Optimized

Oral Health Clinical Research Center

Director: Bryan Michalowicz Founded 1990, $2.5 M NIH grant Multi-purpose research clinic consisting of 10 dental operatories Translate advances in the basic and applied sciences to the clinical setting Test new technologies in dental care or delivery

Periodontitis and systemic disease

5U01DE014338-06, Michalowicz (PI)

EFFECTS OF PERIODONTAL THERAPY ON PRETERM BIRTH

Treatment of periodontitis in pregnant women improves periodontal disease and is safe but does not significantly alter rates of preterm birth, low birth weight, or fetal growth restriction. 1UO1 DE018902, Engebretson (PI)

DIABETES AND PERIODONTICS TRIAL

Determine if periodontal treatment improves glycemic control in type II diabetics with moderate to advanced periodontitis

Launched 2002 NIDCR contract $ 5.9 M Jim Fricton (PI) Sandra Myers (Repository) Lois Kehl (Neuroscience) John Look (Registry) • A variety of therapeutic approaches have evolved for the relief of TMJD symptoms. Implants have been used primarily to replace the articular disc of the joint and the condylar head of the mandible. Long-term success and functioning of these implants remains a major problem.

A neural pathway for itch

Steve Davidson, Xijing Zhang, Sergey G Khasabov, Donald A Simone & Glenn J Giesler Jr Department of Neuroscience, Department of Diagnostic and Biological Sciences.

Nature Neuroscience 12, 544 - 546 (2009)

“scratching the cutaneous receptive field of primate STT neurons produced inhibition during histamine-evoked activity but not during spontaneous activity or activity evoked by a painful stimulus, suggesting that scratching inhibits the transmission of itch in the spinal cord in a state-dependent manner.”

News stories carried by NYT, BBC, Reuters, MPR

A look ahead

A diverse research program Stabilize funding: Review of Summary Statements Grant Writers Club Research Incentive Plan Organize research themes Meet the Program Director Increased collaboration to reach critical mass