Overview of Plant Stem Cell Product

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Transcript Overview of Plant Stem Cell Product

Overview of Plant Stem Cell Products in Cosmetics

Assoc. Prof. Dr. Ubonthip Nimmannit

“Plant Stem Cell in Cosmetics” 25 August 2010

What are stem cells?

• Unprogrammed cell • Differentiate into cells with specific function • Advantage – Regenerative medicine • Stimulate healing • Extended healthy life span


stem cells

Reddy lab, UC Riverside

Stem cells

• Self-renewal • Generate differentiated cells General features of a stem-cell niche.

Sablowski,TRENDS in Cell Biology, Vol.14,2004

Animal and Human Stem Cells • Embryonic stem cells – Pluripotent differentiation potential • Adult stem cells – To maintain and repair tissue • The same DNA and the same gene – Signal inside the cell – epigenetic signals tag DNA – Surrounding histone protein: regulate gene

Plant stem cells

• Shoot apical meristem • Root apical meristem – Epigenetic – Totipotent http :// www .

microscopyu .

com / staticgallery / smz1500 / generalizedplantcellstem .


Meristems • specialized proliferation tissue – the growing tip of roots and shoots – generate new cells Dinneny and Benfey, Cell 132, 2008

Root meristem

• Quiescent center cells (4 cells) • Single layer of stem cells • Daughter cell (2 cells) – Cell renewal – Formation of mature tissue Dinneny and Benfey, Cell 132, 2008

Positioning the Root Stem Cell Niche Dinneny and Benfey, Cell 132, 2008

Shoot meristem

• Organizing center – Several layers of cells – Plant growth hormone • Promote cell cycle activity • Promote growth • Shoot identity Dinneny and Benfey, Cell 132 , 2008

Shoot apical meristem Branch Leaves Flower

Plant shoot apical meristem (SAM) and root apical meristem (RAM) SC niches. The organizing-centre cells provide signals for maintenance of the overlying SCs, which are surrounded by a TA population of cells in the meristem peripheral zone (PZ). In the RAM, the quiescent centre (QC) is the source of SC maintenance signals.

Singh and Bhalla, TRENDS in Plant Science, Vol.11, 2006

The role of stem cells in the skin • Epidermis – stratified epithelium – interfollicular epidermis • Hair follicles • Sebaceous glands

The hair bulge contains multipotent stem cells that contribute to the lineages of the epidermis, the sebaceous gland and the hair follicle Schmid et al., SÖFW-Journal | 134 | 5-2008

Epidermal stem cell generates transit amplifying cells that differentiate to form the stratified layers Schmid et al., SÖFW-Journal | 134 | 5-2008



Colorless mass callus Individual/ small cell clusters in liquid culture

Plant stem cell and their propagation in culture • Sterile condition • Standardized condition

Plant stem cell products

• Centella asiatica cell culture 20% • Echinacea angustifolia cell culture 20% • Buddleja davidii cell culture 20% • Leontopodium alpinum cell culture 20% • Malus domestica fruit cell culture extract


• Stimulate human stem cell growth • Maintains the self renewal capacity of stem cells • Increases longevity of human skin stem cells • Delays senescence of essential cells • Combat chronological aging • Preserve the youthful look and the vitality of skin • neutralize, often reversing, the effects of aging on the skin • protect stem cells from death due to UV overexposure • protects human skin stem cells from stress, thus decreasing wrinkles and producing younger, fresher looking skin .

Plant stem cell products

Plant stem cell products


with 20% Plant Stem Cells

It’s all about PERCENTAGE It’s all about SYNERGY

PhytoCellTec Malus Domestica (Swiss Apple) 20% Plant Stem Cells +Phytosteron - Wild Yam and Soy Bean Sterols

Plant stem cell cream

Lancome Paris Absolue Precious Cells Advanced Regenerating and Reconstructing Cream SPF15 Price: $150

Amore Pacific IOPE Plant Stem Cell Skin Renewal Eye Cream

Price: $60

Plant stem cell cream

emerginC protocell bio active stem cell face cream . Price: $90

Serious Skin Care Replicate Renew Plant Stem Cell Double Power Concentrate

Price: $46.50

Plant stem cell serum

La Mer The Regenerating Serum Price: $250 Helena Rubinstein Prodigy Powercell Price: $120 Elions stem cell serum Price: $25

Plant stem cell : Anticellulite

Adonia LegTone Serum Price: $120 Collistar Intensive Anticellulite Serum Price: $60

Thank you for your attention