Transcript New Delivery Systems from Dow Corning

New Delivery Systems from
Dow Corning
December 2005
Desired result: 3 take-aways
• Why Dow Corning is committed to providing you with the
broadest range of delivery system technologies
• Our existing technologies, our resources to customize
solutions that meet your formulating needs exactly, and
where we’ll continue to invest
• The strength of our in-house experts and alliance partners
Agenda
• Strategic insight into the Life Sciences business
• Deliver the Difference — the vision for our delivery
systems technologies portfolio
• Technical overview
• Phospholipid-based Vesicles
• Silicone Vesicles
• Micro-encapsulation
• Silicone Elastomer Blends
Strategic Insight
• Our Life Science’s vision is to improve the quality of life
in the markets we serve
• Our mission is to be your ideal supplier of performance
enhancing materials — including those that deliver active
ingredients
• Our objective is to collect and offer various, diverse
delivery technologies
Strategic Insight
• Our strategy is highly integrated and includes but is not
limited to:
- Relying on our 60+ year heritage designing and
formulating functional specialty chemicals
- Exploiting our global supply chain that reliably delivers
the highest quality material
- Leveraging our strong customer relationships to
collaborate and innovate custom solutions-
The Benefit to You
• “One stop” shopping — materials, technical support,
formulating expertise, application knowledge, EHS
documentation, analytical services, performance testing
capabilities, customized solutions on a global scale
• A broader choice of ingredients that — in combination
with silicones — promote synergistic performance
benefits
Next steps
Developing a delivery systems technologies portfolio
is a journey, not a destination!
Deliver the Difference
Why Delivery Systems
• The market’s growing at a double digit rate
• Consumers demand convenience (multifunctionality),
healthful/youthful appearance (well being), natural
ingredients (vitamins, botanicals) and environmental
protection (antioxidants, UV/sun blocks) — active
ingredients can meet these expectations
• Delivery technologies are formulation specific — few
suppliers are consolidating multiple technologies under
one offering
Alliances and Partnerships
• Silicone-based technologies have some intrinsic
limitations and cannot meet all of the key market needs
by themselves
• In order to fulfill our vision of a global, world-class
delivery systems provider we sought leading edge
technology partners to fill the gap
• Lipo Chemicals, Inc. and Lipo Technologies, Inc. and
Dow Corning have formed an alliance to offer microencapsulation technologies as part of our offering
Delivery Systems Portfolio
Introducing Four
Delivery Technologies
• Phospholipid-based Vesicles
• Silicone Vesicles
• Micro- and milli- encapsulation Systems
• Silicone Elastomer Blends
Phospholipid-based Vesicles
Dow Corning® Liposomes
Dow Corning® Liposomes
• Combined effect of a high level of phosphatidylcholine and
high level of dilinoleoylphosphatidylcholine
•
•
•
•
Soy bean lecithin = GMO free
Unilamellar liposomes
Physical and chemical stability
Penetration of the upper layers of skin
• Innovative testing capabilities to prove vitamin stability,
efficacy and penetration (ESR)
Dow Corning® Liposomes
Penetrating Liposome System
• Penetrating line designed to supply cosmetic actives in
the upper layers of the skin
Non-Penetrating Liposome System
• Non-Penetrating line designed to supply cosmetic
actives on the surface of the skin
• Penetration is prevented by the use of a sterically
hindered triglyceride
Commercially available loaded with a variety of cosmetic
actives with the possibility for customization
Dow Corning® Silicone Vesicles
Dow Corning® Silicone Vesicles
• Silicone vesicles are hollow particles with water at the
exterior and interior, and a bilayer that contains the particle.
• Capable of encapsulating both lipophilic and hydrophilic
actives.
• New “assembly-required” vesicles developed with attractive
morphologies.
% Silicone in SPE
High
Assembly-Required
Vesicles
Self-Assembly
Vesicles
Med
New
Micelles
Low
Low
Med
D/D’ Ratio in MDxD(EO12)yM
High
Dow Corning® Silicone Vesicles
Two silicone vesicles are currently under development based on:
• rake SPE
• (AB)n SPE
Actives encapsulated:
• Vitamins (vitamin A palmitate, vitamin C)
• Sunscreens, and
• Fragrances.
Stability of Si vesicle encapsulated actives demonstrated.
Encapsulation of customer’s specific actives possible.
Micro- and Milli- encapsulation
Systems
Lipocapsules®
• Gelatin Lipocapsules®
Limitations
Advantages
•
• Animal Derived (Gelatin)
• CMC – Gum Arabic•
•
Separation
of
Incompatibles
Carrgeenan
•
• 10-3000 microns• average
Target or Sustained Release•
diameter
•
• Prevent
Oxidation
• 50 – 97% Internal
phase
Water insoluble IP only
Soften at pH 8.5 and higher
Permeable to solvents
Residue after rupture
No dry over 500 microns
• Filling requirements
• Improve Flow Characteristics
PMU Lipocapsules®
Limitations
• Convert Liquids to Solids
• Synthetic Derived
• Water insoluble IP only
•
Improved
Aesthetics
• Polyoxymethylene Urea
• Soften at pH 8.5 and higher
• Methoxymethyl Methylol
• Supplied slurry, cake or dry• Fragile at sizes > 100
Melamine
powder
microns
• 5 –100 microns average
diameter
• Residue after rupture
• 50-80% Internal Phase
• Filling requirements
Lipospheres®
Agar
• Polysaccharide
• 500 – 400 microns
• 25% Internal Phase
•
•
•
Alginate
• Calcium Alginate
• 500-4000 microns
• 25% Internal Phase
Advantages
Gellan
• Heteropolysaccharide
• 500-4000 microns
• 25% Internal Phase
• VegetableLimitations
derived
Limitations
Limitations
•
Water
soluble
IP
capable
•
Solvent
permeable
Solvent permeable
• Solvent permeable
•
Slurry
only
• Water insoluble IP capable
Slurry only
• Slurry only
•
Reversible
reaction
Filling requirements
• No residue
after rupture• Filling requirements
• Filling requirements
• Target or sustained release
• Improved aesthetics
Lipobead™
Vegetable Derived
Animal Derived
•
•
•
•
•
• Lactose
• Cellulose
• HPMC
• 700 & 1500 microns Average
• 5% Internal Phase
capable
Mannitol
Cellulose
HPMC
700 & 1500 microns Average
5% Internal Phase• Water soluble IP
Advantages
•
•
•
•
•
•
Water insoluble IP capable
Supplied as dry prills
Extended hydration time
No residual after rupture
Target Limitations
or sustained release
Improved
Solventaesthetics
Permeable
Lipoparticle™
Vegetable Derived
Synthetic
• Cellulose
• Nylon 12
Advantages
• Cyclodextrins
• 5-500 Microns Average
• Water soluble IP capable
• 5-500 Microns
30%
Internal Phase
• Water insoluble• IP
capable
Average
• Convert liquids to solids
• 30% Internal• Phase
Substrate for overcoat
• Substrate for granulation
Limitations
• Target or sustained release
Solvent Permeable
• Improve flow characteristics
Dispersion considerations
Dow Corning® Silicone Elastomer
Blends
Dow Corning® Silicone Elastomer Blends
• A crosslinked silicone elastomer gel particle swollen in
various cosmetic fluids.
• The unique fluid-in-gel particle offers a very desirable
smooth, silky skin feel.
• Soft gel particles of 20 – 80 um size.
• Two options to incorporate actives:
• Post-loading:
• Pre-loading:
Cosmetic Fluids
Si elastomer
Actives
Dow Corning® Silicone Elastomer Blends
• Actives investigated: vitamins, fragrances and sunscreens.
• Stability in both pre- and post-loaded SEBs and cosmetic
formulations.
• Excellent skin sensory feel retained in active-entrapped
SEBs.
Stability of SEB Entrapped Vitamin A Palmitate
in Body Lotions
Relative % VAP Change
0%
-20%
-40%
SEB 1 containing O/W lotion
-60%
SEB 2 containing O/W lotion
SEB 7 containing O/W lotion
-80%
0
4
8
Weeks @ 40 °C
12
16
For More Information Please Contact
[email protected]