Transcript HYALUSPHERE - Consumers Guides

HYALUSPHERE
Encapsulated hyaluronic acid
Fill in wrinkles
by injection-like
effect
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Biological context
Hyaluronic acid & Aging
• The skin contains over 50% of the hyaluronic acid (HA) present in our body. As a key
component of the dermis, HA keeps the skin smooth and plump
• HA level gradually decreases over time, resulting from synthesis/degradation unbalance
• 50-year-olds are estimated to have lose half the amount of HA they had in youth
=>The skin dries out and loses its baby-skin smoothness
• Hyalusphere is vectorized HA that helps the skin recover its volume and fullness to
fill in wrinkles
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HYALUSPHERE
COMPOSITION
Hyalusphere is high molecular weight hyaluronic acid (PM: 1-1.4 MDa) encapsulated in a
patented microencapsulation technology, Spherulite®
Hyaluronic acid
• HA is produced by biotechnology process, using lactic bacteria and renewable vegetal substrate
Spherulite
•
Hyaluspheres are non ionic Spherulites encapsulating HA within the aqueous interfaces
•
Spherulites penetrate into the deepest cutaneous layers and progressively deliver hyaluronic acid in
the target activity site for a long lasting effect
Spherulite Technology
•
Spherulites are multi-layered microspheres of surfactants encapsulating active ingredients. They are
composed of surfactant bi-layers and aqueous interfaces.
Performances of the technology
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Aqueous phase
•
Optimization of the skin adhesion or penetration
Surfactant bilayers
•
Time release of the active ingredients for a long lasting effect
Mechanism of action
1. Optimization of the skin
3. Plumping effect
penetration
Increase of HA content in the
Spherulites enable high
dermis leads to a plumping
molecular weight HA to reach
effect to fill in wrinkle
the deep skin layers
2. Time release of HA
Spherulite layers open
successively for a controlled
release of the HA and a long
lasting effect
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In vivo Tests
Protocol
A panel (12 volunteers, from 36 to 55 years old) applied on the crows feet areas :
- a cream formulated with 3% Hyalusphere
- a cream formulated with 2% of a positive reference*
Average wrinkles were quantified at T0, T1h and T6h using a specific Software (Quantirides® )
*
*
*
*
Hyalusphere significantly smoothes average
wrinkles and outperforms the positive
reference with fast and long term results
Positive reference
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Hyalusphere
* Positive reference : HA microspheres
In vivo Tests
Photographs of the crows feet - Before / after treatment (T1h and T6h)
T0
T1h
T6h
Hyalusphere
3%
T0
T1h
T6h
Positive reference
2%
Hyalusphere is a potent anti-wrinkle active ingredient that offers a
youthful and smooth look within 1 hour
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Cosmetic uses
INCI Name:
Water (and) Sucrose palmitate (and) Tocopheryl acetate
(and) Glyceryl linoleate (and) Sodium hyaluronate
Preservative :
Hyalusphere : Phenonip
Hyalusphere PF : Phenoxyethanol and Potassium Sorbate
Appearance :
White cream
Cosmetic applications
Hyalusphere is recommended from 2% à 3% in :
• Anti-wrinkle products
• Eye contour / Lip contour serums
• Face resculpting creams
• Lip plumping care
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Conclusion
• Patented vectorisation technology
• Redensifies the skin to fill in
wrinkles
• Proven efficacy
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FORMULATION
Anti-wrinkle cream
Process
Phase
Components
%
Xyliance
Caprilic/capric triglyceride
Preservative
5
20
Qs
B
Aqua
Qsp 100%
C
Hyalusphere
Aqua
3
3
D
Parfum
Qs
A
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1.
Prepare A and B under agitation, in a Bain Marie at
70°C
2.
At 70°C, add B to A under stirring (3000 rpm Polytron PT 300) during 5 minutes
3.
Let get cold under agitation
4.
At 30°C, add successively under agitation C and D
and let get cold at room temperature